PMID- 28910373 OWN - NLM STAT- MEDLINE DCOM- 20171012 LR - 20181113 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 12 IP - 9 DP - 2017 TI - Lack of association of MRI determined subclinical cardiovascular disease with dizziness and vertigo in a cross-sectional population-based study. PG - e0184858 LID - 10.1371/journal.pone.0184858 [doi] LID - e0184858 AB - OBJECTIVE: We investigated the association between subclinical cardiovascular diseases assessed by MRI examination and symptoms of dizziness and vertigo in participants of a population-based sample. METHODS: Data from 400 participants (169 women) aged from 39 to 73 of a cross-sectional MRI sub-study of the "Kooperative Gesundheitsforschung in der Region Augsburg" (KORA) FF4 study from the south of Germany was used. MRI determined subclinical cardiovascular diseases include left and right ventricular structure and function as well as the presence of carotid plaque and carotid wall thickness. Cerebrum diseases include white matter lesions (WML) and cerebral microbleeds (CMB). The main outcomes of dizziness and vertigo were assessed by standardized interview. Logistic regression models were applied and adjusted odds ratios (OR) with 95% confidence intervals (CI) were provided. RESULTS: Lifetime and 12-month prevalence of dizziness and vertigo were 30% (95%CI 26% to 35%) and 21% (95%CI 17% to 26%) respectively in this sample. On multivariable analysis, cardiac and carotid measurements were not associated with dizziness and vertigo excluding orthostatic vertigo (20%, 95CI 16% to 24%). Only in male participants, there was a significant association between WML and the presence of dizziness and vertigo (OR = 2.95, 95%CI 1.08 to 8.07). There was no significant association of CMB with dizziness and vertigo. However, CMB and WML were tending to associate with a higher risk of dizziness and vertigo in the whole sample (CMB: OR = 1.48, 95%CI 0.70; 3.15; WML: OR = 1.71, 95%CI 0.80 to 3.67;), in persons with prediabetes and diabetes (WML: OR = 2.71, 95%CI 0.89 to 8.23) and in men with normal glucose metabolism (CMB: OR = 2.60, 95%CI 0.56 to 12.0; WML: OR = 3.08, 95%CI 0.58 to 16.5). CONCLUSIONS: In this sample of participants without manifest cardiovascular diseases, subclinical left and right ventricular function and carotid structure were consistently not associated with dizziness and vertigo. Subclinical cerebrum measurements, however, tend to increase the risk for dizziness and vertigo, especially in men and in persons with prediabetes or diabetes. FAU - Lorbeer, Roberto AU - Lorbeer R AUID- ORCID: 0000-0002-2224-9208 AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. FAU - Hetterich, Holger AU - Hetterich H AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. FAU - Strobl, Ralf AU - Strobl R AD - Institute of Medical Information Processing, Biometrics and Epidemiology, LMU Munich, Munich, Germany. FAU - Schafnitzel, Anina AU - Schafnitzel A AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. FAU - Patscheider, Hannah AU - Patscheider H AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. FAU - Schindler, Andreas AU - Schindler A AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. FAU - Muller-Peltzer, Katharina AU - Muller-Peltzer K AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. FAU - Sommer, Wieland AU - Sommer W AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. FAU - Peters, Annette AU - Peters A AD - Institute of Epidemiology II, Helmholtz Zentrum Munchen, Neuherberg, Germany. AD - German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. AD - German Center for Cardiovascular Disease Research (DZHK e.V.), Munich, Germany. FAU - Meisinger, Christa AU - Meisinger C AD - Institute of Epidemiology II, Helmholtz Zentrum Munchen, Neuherberg, Germany. AD - Chair of Epidemiology, LMU Munich, UNIKA-T Augsburg, Augsburg, Germany. FAU - Heier, Margit AU - Heier M AD - Institute of Epidemiology II, Helmholtz Zentrum Munchen, Neuherberg, Germany. AD - KORA Myocardial Infarction Registry, Central Hospital of Augsburg, Augsburg, Germany. FAU - Rathmann, Wolfgang AU - Rathmann W AD - Department of Biometrics and Epidemiology, German Diabetes Center, Duesseldorf, Germany. FAU - Bamberg, Fabian AU - Bamberg F AD - Department of Radiology, University Hospital, LMU Munich, Munich, Germany. AD - Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tubingen, Tubingen, Germany. FAU - Grill, Eva AU - Grill E AD - Institute of Medical Information Processing, Biometrics and Epidemiology, LMU Munich, Munich, Germany. AD - German Center for Vertigo and Balance Disorders, LMU Munich, Munich, Germany. AD - Munich Center of Health Sciences (MC-Health), LMU Munich, Munich, Germany. LA - eng PT - Journal Article DEP - 20170914 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adult MH - Aged MH - Brain Diseases/*diagnostic imaging MH - Cardiovascular Diseases/*diagnostic imaging MH - Cross-Sectional Studies MH - Dizziness/*epidemiology MH - Female MH - Germany/epidemiology MH - Humans MH - Logistic Models MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Prevalence MH - Risk Factors MH - Ventricular Function MH - Vertigo/*epidemiology PMC - PMC5599022 COIS- Competing Interests: The KORA-MRI sub-study was supported by an unrestricted research grant from Siemens Healthcare. This does not alter our adherence to PLOS ONE policies on sharing data and materials. EDAT- 2017/09/15 06:00 MHDA- 2017/10/13 06:00 PMCR- 2017/09/14 CRDT- 2017/09/15 06:00 PHST- 2016/09/28 00:00 [received] PHST- 2017/09/03 00:00 [accepted] PHST- 2017/09/15 06:00 [entrez] PHST- 2017/09/15 06:00 [pubmed] PHST- 2017/10/13 06:00 [medline] PHST- 2017/09/14 00:00 [pmc-release] AID - PONE-D-16-38795 [pii] AID - 10.1371/journal.pone.0184858 [doi] PST - epublish SO - PLoS One. 2017 Sep 14;12(9):e0184858. doi: 10.1371/journal.pone.0184858. eCollection 2017.