PMID- 28910963
OWN - NLM
STAT- MEDLINE
DCOM- 20180816
LR  - 20180816
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 612
DP  - 2018 Jan 15
TI  - Placental transfer of persistent organic pollutants and feasibility using the 
      placenta as a non-invasive biomonitoring matrix.
PG  - 1498-1505
LID - S0048-9697(17)31757-6 [pii]
LID - 10.1016/j.scitotenv.2017.07.054 [doi]
AB  - The placenta is a crucial organ for the supply of oxygen and nutritional elements 
      from mother to fetus. Several studies have reported evidence of the placental 
      transfer of persistent organic pollutants (POPs). Despite the importance of 
      prenatal exposure to POPs, the transport process of POPs via the human placenta 
      is not well understood. To investigate the transport processes of these 
      contaminants and to assess the feasibility of the placenta as a non-invasive 
      biological matrix, we measured 19 polychlorinated biphenyls (PCBs), 18 
      organochlorine pesticides (OCPs), and 24 polybrominated diphenyl ethers (PBDEs) 
      in placenta tissues. The total concentrations of PCBs, OCPs, and PBDEs in 
      placental tissues ranged from 0.36 to 75.2 (median: 5.85) ng/g lipid wt, 1.37 to 
      250 (63.5) ng/g lipid wt, and 1.21 to 427 (11.7) ng/g lipid wt, respectively. The 
      BDE 209 concentrations were higher than those reported in previous studies 
      presumably because of the high consumption of deca-BDE technical mixtures in 
      Korea. The concentrations of all of the POPs in placental tissues correlated 
      significantly with each other, but BDE 209 concentration did not correlate with 
      that of any other contaminants possibly because of different exposure sources and 
      kinetics. Maternal age, body mass index, and parity were contributors to the 
      accumulation of several POPs in the placenta. Partitioning ratios between 
      maternal blood-placenta-cord blood showed that lower molecular-weight and 
      hydrophobic POPs were preferentially transported from maternal blood to the 
      placenta and that higher molecular-weight and hydrophobic contaminants tended to 
      remain in placental tissues. Regression analysis showed significant relationships 
      between the POP concentrations in multiple biological matrices such as maternal 
      blood, placenta, cord blood, and meconium. These relationships suggest that the 
      placenta can be used as a non-invasive matrix for biomonitoring prenatal exposure 
      to several POPs.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Jeong, Yunsun
AU  - Jeong Y
AD  - Department of Marine Science and Convergence Engineering, Hanyang University, 
      Ansan 15588, Republic of Korea.
FAU - Lee, Sunggyu
AU  - Lee S
AD  - Department of Marine Science and Convergence Engineering, Hanyang University, 
      Ansan 15588, Republic of Korea.
FAU - Kim, Sunmi
AU  - Kim S
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Park, Jeongim
AU  - Park J
AD  - College of Natural Sciences, Soonchunhyang University, Asan 31538, Republic of 
      Korea.
FAU - Kim, Hai-Joong
AU  - Kim HJ
AD  - College of Medicine, Korea University, Seoul 02841, Republic of Korea.
FAU - Choi, Gyuyeon
AU  - Choi G
AD  - College of Medicine, Soonchunhyang University, Seoul 31538, Republic of Korea.
FAU - Choi, Sooran
AU  - Choi S
AD  - College of Medicine, Inha University, Incheon 22212, Republic of Korea.
FAU - Kim, Sungjoo
AU  - Kim S
AD  - College of Medicine, Hallym University, Seoul 24252, Republic of Korea.
FAU - Kim, Su Young
AU  - Kim SY
AD  - College of Medicine, Jeju National University, Jeju 63243, Republic of Korea.
FAU - Kim, Sungkyoon
AU  - Kim S
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Choi, Kyungho
AU  - Choi K
AD  - School of Public Health, Seoul National University, Seoul 08826, Republic of 
      Korea.
FAU - Moon, Hyo-Bang
AU  - Moon HB
AD  - Department of Marine Science and Convergence Engineering, Hanyang University, 
      Ansan 15588, Republic of Korea. Electronic address: hbmoon@hanyang.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20170925
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Environmental Monitoring/*methods
MH  - Environmental Pollutants/*analysis
MH  - Female
MH  - Halogenated Diphenyl Ethers/analysis
MH  - Humans
MH  - Hydrocarbons, Chlorinated/analysis
MH  - *Maternal Exposure
MH  - Pesticides/analysis
MH  - Placenta/*chemistry
MH  - Polychlorinated Biphenyls/analysis
MH  - Pregnancy
MH  - Republic of Korea
OTO - NOTNLM
OT  - BDE 209
OT  - Biomonitoring
OT  - POPs
OT  - Partitioning
OT  - Placental transfer
EDAT- 2017/09/16 06:00
MHDA- 2018/08/17 06:00
CRDT- 2017/09/16 06:00
PHST- 2017/04/29 00:00 [received]
PHST- 2017/06/14 00:00 [revised]
PHST- 2017/07/07 00:00 [accepted]
PHST- 2017/09/16 06:00 [pubmed]
PHST- 2018/08/17 06:00 [medline]
PHST- 2017/09/16 06:00 [entrez]
AID - S0048-9697(17)31757-6 [pii]
AID - 10.1016/j.scitotenv.2017.07.054 [doi]
PST - ppublish
SO  - Sci Total Environ. 2018 Jan 15;612:1498-1505. doi: 
      10.1016/j.scitotenv.2017.07.054. Epub 2017 Sep 25.