PMID- 28911256
OWN - NLM
STAT- MEDLINE
DCOM- 20180905
LR  - 20180921
IS  - 2325-9582 (Electronic)
IS  - 2325-9574 (Linking)
VI  - 16
IP  - 6
DP  - 2017 Nov/Dec
TI  - Immune Reconstitution Inflammatory Syndrome in Patients with AIDS and 
      Disseminated Coccidioidomycosis: A Case Series and Review of the Literature.
PG  - 540-545
LID - 10.1177/2325957417729751 [doi]
AB  - Coccidioidomycosis causes substantial morbidity and mortality in endemic areas, 
      and dissemination is frequent in patients with impaired cellular immunity such as 
      AIDS. Immune reconstitution inflammatory syndrome (IRIS) is paradoxical clinical 
      worsening after initiation of antiretroviral therapy (ART) in a patient with HIV 
      and a simultaneous opportunistic infection (OI). Immune reconstitution 
      inflammatory syndrome has been well described for a host of mycobacterial, viral, 
      and fungal OIs and malignancies such as Kaposi sarcoma. To date, only 3 cases of 
      IRIS due to coccidioidomycosis have been reported in the literature. At our 
      institution, we report 4 cases of IRIS in HIV-infected patients with disseminated 
      coccidioidomycosis. Unfortunately, all 4 patients died of worsening coccidioidal 
      infection after initiating ART. The optimal timing of ART in patients with AIDS 
      and coccidioidomycosis remains to be elucidated.
FAU - Mu, Anandit
AU  - Mu A
AD  - 1 Division of Infectious Diseases, University of California San Francisco, Fresno 
      Medical Education Program, Fresno, CA, USA.
FAU - Shein, Thwe Thwe
AU  - Shein TT
AD  - 1 Division of Infectious Diseases, University of California San Francisco, Fresno 
      Medical Education Program, Fresno, CA, USA.
FAU - Jayachandran, Priya
AU  - Jayachandran P
AD  - 2 Department of Medicine, University of California San Francisco, Fresno Medical 
      Education Program, Fresno, CA, USA.
FAU - Paul, Simon
AU  - Paul S
AD  - 1 Division of Infectious Diseases, University of California San Francisco, Fresno 
      Medical Education Program, Fresno, CA, USA.
AD  - 2 Department of Medicine, University of California San Francisco, Fresno Medical 
      Education Program, Fresno, CA, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
DEP - 20170914
PL  - United States
TA  - J Int Assoc Provid AIDS Care
JT  - Journal of the International Association of Providers of AIDS Care
JID - 101603896
RN  - 0 (Anti-HIV Agents)
RN  - 0 (Antifungal Agents)
RN  - 0 (liposomal amphotericin B)
RN  - 7XU7A7DROE (Amphotericin B)
RN  - 8VZV102JFY (Fluconazole)
SB  - IM
MH  - AIDS-Related Opportunistic Infections/*drug therapy/etiology
MH  - Abscess/drug therapy/etiology
MH  - Acquired Immunodeficiency Syndrome/complications/*drug therapy
MH  - Adult
MH  - Amphotericin B/*therapeutic use
MH  - Anti-HIV Agents/*adverse effects
MH  - Antifungal Agents/therapeutic use
MH  - Brain/diagnostic imaging
MH  - Central Nervous System Fungal Infections/diagnostic imaging
MH  - Coccidioidomycosis/*drug therapy/etiology
MH  - Fatal Outcome
MH  - Female
MH  - Fluconazole/therapeutic use
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*chemically induced
MH  - Liver/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
OTO - NOTNLM
OT  - HIV/AIDS
OT  - antiretroviral therapy
OT  - coccidioidomycosis
OT  - immune reconstitution inflammatory syndrome
EDAT- 2017/09/16 06:00
MHDA- 2018/09/06 06:00
CRDT- 2017/09/16 06:00
PHST- 2017/09/16 06:00 [pubmed]
PHST- 2018/09/06 06:00 [medline]
PHST- 2017/09/16 06:00 [entrez]
AID - 10.1177/2325957417729751 [doi]
PST - ppublish
SO  - J Int Assoc Provid AIDS Care. 2017 Nov/Dec;16(6):540-545. doi: 
      10.1177/2325957417729751. Epub 2017 Sep 14.