PMID- 2891144
OWN - NLM
STAT- MEDLINE
DCOM- 19880113
LR  - 20191210
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 28
IP  - 2
DP  - 1987 Oct
TI  - Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").
PG  - 153-6
AB  - Eight male rats were trained to discriminate 2.0 mg/kg 
      N-ethyl-3,4-methylenedioxyamphetamine (MDE) from its vehicle using a two-lever, 
      food-motivated operant discrimination task. Once trained, the rats showed a 
      dose-dependent decrease in discriminative accuracy following administration of 
      decreased doses of MDE (ED50 = 0.75 mg/kg). Administration of 1.5 mg/kg 
      3,4-methylenedioxymethamphetamine (MDMA), a recently restricted Schedule I drug, 
      produced 100% MDE-appropriate responding in the MDE-trained rats and decreased 
      discriminative performance was similarly observed following lower doses of MDMA 
      (ED50 = 0.62 mg/kg). The difference in relative potencies of MDE and MDMA in rats 
      is reminiscent of those seen in human abusers who report effective oral 
      psychotomimetic doses. Time-course data indicated that MDE has a fast onset, 100% 
      drug-correct responding 10 min post-injection, and a peak effect between 10-20 
      min with declining effect at 60-120 min post-administration. These findings along 
      with those of others show a pharmacological similarity between MDE and MDMA. 
      Implications as to the future scheduling of MDE are discussed.
FAU - Boja, J W
AU  - Boja JW
AD  - Department of Pharmacology, Northeastern Ohio Universities College of Medicine, 
      Rootstown 44272.
FAU - Schechter, M D
AU  - Schechter MD
LA  - eng
GR  - DA 04181/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Amphetamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Discrimination, Psychological
MH  - Dose-Response Relationship, Drug
MH  - Legislation, Drug
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Time Factors
MH  - United States
EDAT- 1987/10/01 00:00
MHDA- 1987/10/01 00:01
CRDT- 1987/10/01 00:00
PHST- 1987/10/01 00:00 [pubmed]
PHST- 1987/10/01 00:01 [medline]
PHST- 1987/10/01 00:00 [entrez]
AID - 0091-3057(87)90206-1 [pii]
AID - 10.1016/0091-3057(87)90206-1 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1987 Oct;28(2):153-6. doi: 10.1016/0091-3057(87)90206-1.