PMID- 28911473
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210119
IS  - 2224-6614 (Electronic)
IS  - 1021-9498 (Print)
VI  - 22
IP  - 4
DP  - 2014 Dec
TI  - Binding interactions of niclosamide with serum proteins.
PG  - 549-555
LID - S1021-9498(14)00057-X [pii]
LID - 10.1016/j.jfda.2014.03.004 [doi]
AB  - A study of the binding of niclosamide (NC) to serum proteins such as human serum 
      albumin, hemoglobin, and globulin was carried out using fluorescence and 
      UV-visible spectroscopy. Interactions between NC and these proteins were 
      estimated by Stern-Volmer and van't Hoff equations. The binding constants and the 
      thermodynamic parameters, DeltaH, DeltaS, and DeltaG at different temperatures were also 
      determined by using these equations. Data showed that NC may exhibit a static 
      quenching mechanism with all proteins. The thermodynamic parameters were 
      calculated. Data showed that van der Waals interactions and hydrogen bonds are 
      the main forces for human serum albumin and hemoglobin. Globulin, however, bound 
      to NC via hydrophobic interaction. The spectral changes of synchronous 
      fluorescence suggested that both the microenvironment of NC and the conformation 
      of the proteins changed in relation to their concentrations during NC's binding.
CI  - Copyright (c) 2014. Published by Elsevier B.V.
FAU - Maltas, Esra
AU  - Maltas E
AD  - Selcuk University, Faculty of Science, Department of Chemistry, Konya 42031, 
      Selcuklu, Turkey. Electronic address: esramaltas@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20140506
PL  - China (Republic : 1949- )
TA  - J Food Drug Anal
JT  - Journal of food and drug analysis
JID - 101630927
PMC - PMC7129377
OTO - NOTNLM
OT  - Fluorescence quenching
OT  - Human serum albumin (HSA)
OT  - Niclosamide
OT  - Stern-Volmer equation
OT  - Thermodynamic parameters
COIS- Conflicts of interest The author declares no conflicts of interest.
EDAT- 2014/12/01 00:00
MHDA- 2014/12/01 00:01
PMCR- 2014/05/06
CRDT- 2017/09/16 06:00
PHST- 2013/11/19 00:00 [received]
PHST- 2014/03/27 00:00 [revised]
PHST- 2014/03/28 00:00 [accepted]
PHST- 2017/09/16 06:00 [entrez]
PHST- 2014/12/01 00:00 [pubmed]
PHST- 2014/12/01 00:01 [medline]
PHST- 2014/05/06 00:00 [pmc-release]
AID - S1021-9498(14)00057-X [pii]
AID - jfda-22-04-549 [pii]
AID - 10.1016/j.jfda.2014.03.004 [doi]
PST - ppublish
SO  - J Food Drug Anal. 2014 Dec;22(4):549-555. doi: 10.1016/j.jfda.2014.03.004. Epub 
      2014 May 6.