PMID- 28912194
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20221207
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 7
IP  - 9
DP  - 2017 Sep 14
TI  - Assessing oral medication adherence among patients with type 2 diabetes mellitus 
      treated with polytherapy in a developed Asian community: a cross-sectional study.
PG  - e016317
LID - 10.1136/bmjopen-2017-016317 [doi]
LID - e016317
AB  - OBJECTIVES: The disease burden of type 2 diabetes mellitus (T2DM) is rising due 
      to suboptimal glycaemic control leading to vascular complications. Medication 
      adherence (MA) directly influences glycaemic control and clinical consequences. 
      This study aimed to assess the MA of patients with T2DM and identify associated 
      factors. DESIGN: Analysis of data from a cross-sectional survey and electronic 
      medical records. SETTING: Primary care outpatient clinic in Singapore. 
      PARTICIPANTS: Adult patients with T2DM. MAIN OUTCOME MEASURES: MA to each 
      prescribed oral hypoglycaemic agent (OHA) was measured using the five-question 
      Medication Adherence Report Scale (MARS-5). Low MA is defined as a MARS-R score 
      of <25. Demographic data, clinical characteristics and investigation results were 
      collected to identify factors that are associated with low MA. RESULTS: The study 
      population comprised 382 patients with a slight female predominance (53.4%) and a 
      mean+/-SD age of 62.0+/-10.4 years. 57.1% of the patients had low MA to at least one 
      OHA. Univariate analysis showed that patients who were younger, of Chinese 
      ethnicity, married or widowed, self-administering their medications or taking 
      fewer (four or less) daily medications tended to have low MA to OHA. Logistic 
      regression revealed that younger age (OR 0.97; 95% CI 0.95 to0.99), Chinese 
      ethnicity (OR 2.80; 95% CI 1.53 to5.15) and poorer glycaemic control (HbA1c 
      level) (OR 1.27; 95% CI 1.06 to1.51) were associated with low MA to OHA. 
      CONCLUSIONS: Younger patients with T2DM and of Chinese ethnicity were susceptible 
      to low MA to OHA, which was associated with poorer glycaemic control. Polytherapy 
      was not associated with low MA.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text of 
      the article) 2017. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Lee, Cia Sin
AU  - Lee CS
AD  - SingHealth Polyclinics, Singapore, Singapore.
FAU - Tan, Jane Hwee Mian
AU  - Tan JHM
AD  - SingHealth Polyclinics, Singapore, Singapore.
FAU - Sankari, Usha
AU  - Sankari U
AD  - SingHealth Polyclinics, Singapore, Singapore.
FAU - Koh, Yi Ling Eileen
AU  - Koh YLE
AD  - SingHealth Polyclinics, Singapore, Singapore.
FAU - Tan, Ngiap Chuan
AU  - Tan NC
AD  - SingHealth Polyclinics, Singapore, Singapore.
AD  - Duke-NUS Medical School, Singapore, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20170914
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - *Asian People
MH  - Blood Glucose/*metabolism
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/ethnology/therapy
MH  - *Ethnicity
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Logistic Models
MH  - Male
MH  - *Medication Adherence
MH  - Middle Aged
MH  - Odds Ratio
MH  - Singapore
PMC - PMC5640112
OTO - NOTNLM
OT  - medication adherence
OT  - oral hypoglycemic agent
OT  - polytherapy
OT  - type 2 diabetes mellitus
COIS- Competing interests: None declared.
EDAT- 2017/09/16 06:00
MHDA- 2018/05/23 06:00
PMCR- 2017/09/14
CRDT- 2017/09/16 06:00
PHST- 2017/09/16 06:00 [entrez]
PHST- 2017/09/16 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2017/09/14 00:00 [pmc-release]
AID - bmjopen-2017-016317 [pii]
AID - 10.1136/bmjopen-2017-016317 [doi]
PST - epublish
SO  - BMJ Open. 2017 Sep 14;7(9):e016317. doi: 10.1136/bmjopen-2017-016317.