PMID- 28914193
OWN - NLM
STAT- MEDLINE
DCOM- 20171213
LR  - 20180605
IS  - 1873-4294 (Electronic)
IS  - 1568-0266 (Linking)
VI  - 17
IP  - 28
DP  - 2017 Nov 20
TI  - Chalcone Derivatives: Anti-inflammatory Potential and Molecular Targets 
      Perspectives.
PG  - 3146-3169
LID - 10.2174/1568026617666170914160446 [doi]
AB  - Chalcone or (E)-1,3-diphenyl-2-propene-1-one scaffold has gained considerable 
      scientific interest in medicinal chemistry owing to its simple chemistry, ease in 
      synthesizing a variety of derivatives and exhibiting a broad range of promising 
      pharmacological activities by modulating several molecular targets. A number of 
      natural and (semi-) synthetic chalcone derivatives have demonstrated admirable 
      anti-inflammatory activity due to their inhibitory potential against various 
      therapeutic targets like Cyclooxygenase (COX), Lipooxygenase (LOX), Interleukins 
      (IL), Prostaglandins (PGs), Nitric Oxide Synthase (NOS), Leukotriene D4 (LTD4), 
      Nuclear Factor-kappaB (NF- kappaB), Intracellular Cell Adhesion Molecule-1 (ICAM-1), 
      Vascular Cell Adhesion Molecule-1 (VCAM-1), Monocyte Chemoattractant Protein-1 
      (MCP-1) and TLR4/MD-2, etc. The chalcone scaffold with hydroxyl, methoxyl, 
      carboxyl, prenyl group and/or heterocyclic ring substitution like 
      thiophene/furan/indole showed promising anti-inflammatory activity. In this 
      review, a comprehensive study (from the year 1991 to 2016) on multi-targets of 
      inflammatory interest, related inflammation reactions and their treatment by 
      chalcone-based inhibitors acting on various molecular targets entailed in 
      inflammation, Structure-Activity Relationships (SARs), Mechanism of Actions 
      (MOAs), and patents are highlighted.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Mahapatra, Debarshi Kar
AU  - Mahapatra DK
AD  - Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central 
      University), Bilaspur - 495009, Chhattisgarh, India.
FAU - Bharti, Sanjay Kumar
AU  - Bharti SK
AD  - Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central 
      University), Bilaspur - 495009, Chhattisgarh, India.
FAU - Asati, Vivek
AU  - Asati V
AD  - Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central 
      University), Bilaspur - 495009, Chhattisgarh, India.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Top Med Chem
JT  - Current topics in medicinal chemistry
JID - 101119673
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 5S5A2Q39HX (Chalcone)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/chemical 
      synthesis/chemistry/*pharmacology
MH  - Chalcone/chemical synthesis/chemistry/*pharmacology
MH  - Humans
MH  - Molecular Structure
OTO - NOTNLM
OT  - Chalcone
OT  - inflammatory
OT  - inhibitor
OT  - patent
OT  - pathway
OT  - target.
EDAT- 2017/09/16 06:00
MHDA- 2017/12/14 06:00
CRDT- 2017/09/16 06:00
PHST- 2016/11/01 00:00 [received]
PHST- 2017/04/21 00:00 [revised]
PHST- 2017/04/25 00:00 [accepted]
PHST- 2017/09/16 06:00 [pubmed]
PHST- 2017/12/14 06:00 [medline]
PHST- 2017/09/16 06:00 [entrez]
AID - CTMC-EPUB-85784 [pii]
AID - 10.2174/1568026617666170914160446 [doi]
PST - ppublish
SO  - Curr Top Med Chem. 2017 Nov 20;17(28):3146-3169. doi: 
      10.2174/1568026617666170914160446.