PMID- 28914433
OWN - NLM
STAT- MEDLINE
DCOM- 20181123
LR  - 20181123
IS  - 1869-1889 (Electronic)
IS  - 1674-7305 (Linking)
VI  - 61
IP  - 5
DP  - 2018 May
TI  - Platelet transfusion refractoriness after T-cell-replete haploidentical 
      transplantation is associated with inferior clinical outcomes.
PG  - 569-577
LID - 10.1007/s11427-017-9110-0 [doi]
AB  - Haploidentical stem cell transplantation (haplo-SCT) has been an alternative 
      source of bone marrow for patients without human leukocyte antigen (HLA)-matched 
      donors. The aim of this study was to investigate the relationships between 
      platelet transfusion refractoriness (PTR) and clinical outcomes in the setting of 
      haplo-SCT. Between May 2012 and March 2014, 345 patients who underwent 
      unmanipulated haplo-SCT were retrospectively enrolled. PTR occurred in 20.6% of 
      all patients. Patients in the PTR group experienced higher transplant-related 
      mortality (TRM, 43.7% vs. 13.5%, P<0.001), lower overall survival (OS, 47.9% vs. 
      76.3%, P<0.001) and lower leukemia-free survival (LFS, 47.9% vs. 72.3%, P<0.001) 
      compared to patients in the non-PTR group. The multivariate analysis showed that 
      PTR was associated with TRM (P=0.002), LFS (P<0.001), and OS (P<0.001). The 
      cumulative incidences of PTR in patients receiving >12 platelet (PLT) 
      transfusions (third quartile of PLT transfusions) were higher than in patients 
      receiving either >6 (second quartile) or >3 (first quartile) PLT transfusions 
      (56.1% vs. 41.6% vs. 28.2%, respectively; P<0.001). The multivariate analysis 
      also showed that PTR was associated with the number of PLT transfusions 
      (P<0.001). PTR could predict poor transplant outcomes in patients who underwent 
      haploidentical SCT.
FAU - Fu, Qiang
AU  - Fu Q
AD  - Peking University People's Hospital & Peking University Institute of Hematology, 
      Beijing Key Laboratory of HSCT, Beijing, 100044, China.
FAU - Xu, Lanping
AU  - Xu L
AD  - Peking University People's Hospital & Peking University Institute of Hematology, 
      Beijing Key Laboratory of HSCT, Beijing, 100044, China.
FAU - Zhang, Xiaohui
AU  - Zhang X
AD  - Peking University People's Hospital & Peking University Institute of Hematology, 
      Beijing Key Laboratory of HSCT, Beijing, 100044, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Peking University People's Hospital & Peking University Institute of Hematology, 
      Beijing Key Laboratory of HSCT, Beijing, 100044, China.
FAU - Chang, Yingjun
AU  - Chang Y
AD  - Peking University People's Hospital & Peking University Institute of Hematology, 
      Beijing Key Laboratory of HSCT, Beijing, 100044, China.
FAU - Liu, Kaiyan
AU  - Liu K
AD  - Peking University People's Hospital & Peking University Institute of Hematology, 
      Beijing Key Laboratory of HSCT, Beijing, 100044, China.
FAU - Huang, Xiaojun
AU  - Huang X
AD  - Peking University People's Hospital & Peking University Institute of Hematology, 
      Beijing Key Laboratory of HSCT, Beijing, 100044, China. huangxiaojun@bjmu.edu.cn.
AD  - Peking-Tsinghua Center for Life Sciences, Beijing, 100044, China. 
      huangxiaojun@bjmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20170913
PL  - China
TA  - Sci China Life Sci
JT  - Science China. Life sciences
JID - 101529880
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Lymphocyte Depletion
MH  - Male
MH  - Middle Aged
MH  - Platelet Transfusion/*adverse effects
MH  - Retrospective Studies
MH  - Transfusion Reaction/complications/*mortality
MH  - Transplantation Conditioning/*adverse effects
MH  - *Transplantation, Haploidentical
MH  - Treatment Failure
MH  - Young Adult
OTO - NOTNLM
OT  - PLT transfusion
OT  - clinical outcomes
OT  - platelet transfusion refractoriness
OT  - unmanipulated haploidentical stem cell transplantation
EDAT- 2017/09/16 06:00
MHDA- 2018/11/24 06:00
CRDT- 2017/09/16 06:00
PHST- 2017/01/08 00:00 [received]
PHST- 2017/02/28 00:00 [accepted]
PHST- 2017/09/16 06:00 [pubmed]
PHST- 2018/11/24 06:00 [medline]
PHST- 2017/09/16 06:00 [entrez]
AID - 10.1007/s11427-017-9110-0 [pii]
AID - 10.1007/s11427-017-9110-0 [doi]
PST - ppublish
SO  - Sci China Life Sci. 2018 May;61(5):569-577. doi: 10.1007/s11427-017-9110-0. Epub 
      2017 Sep 13.