PMID- 28914582
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240314
IS  - 2045-8932 (Print)
IS  - 2045-8940 (Electronic)
IS  - 2045-8932 (Linking)
VI  - 7
IP  - 4
DP  - 2017 Oct-Dec
TI  - A case of worsening pulmonary arterial hypertension and pleural effusions by 
      bosutinib after prior treatment with dasatinib.
PG  - 808-812
LID - 10.1177/2045893217733444 [doi]
AB  - A 52-year-old man with a past medical history of chronic myeloid leukemia (CML) 
      in remission developed progressive shortness of breath over a two-month period. 
      He was initially treated with dasatinib for four years, until developing 
      pulmonary arterial hypertension (PAH) with pleural effusions. His symptoms 
      improved after stopping dasatinib. He was then switched to bosutinib for 
      approximately one year, which was then stopped before admission due to worsening 
      shortness of breath. His initial workup showed bilateral pleural effusions with 
      severe PAH and cor pulmonale. He had symptomatic improvement with PAH-specific 
      therapy following discontinuation of the bosutinib. The life expectancy of CML 
      patients has increased in the era of the tyrosine kinase inhibitors (TKIs), and 
      managing adverse events (AEs) of the TKIs and improving quality of life are 
      becoming more important. Pulmonary hypertension (PH) and pleural effusions are 
      rarely reported AEs of bosutinib. More reports with PH and pleural effusions 
      arising after bosutinib use in patients previously treated with dasatinib is 
      furthermore concerning. In this era with novel chemotherapeutic agents, 
      physicians ought to be weary of the significant morbidity implicated by these 
      agents in the lives of patients.
FAU - Seegobin, Karan
AU  - Seegobin K
AD  - 1 Department of Internal Medicine, University of Florida College of Medicine, 
      Jacksonville, FL, USA.
FAU - Babbar, Amit
AU  - Babbar A
AD  - 2 Department of Pulmonary Disease and Critical Care Medicine, University of 
      Florida College of Medicine, Jacksonville, FL, USA.
FAU - Ferreira, Jason
AU  - Ferreira J
AD  - 2 Department of Pulmonary Disease and Critical Care Medicine, University of 
      Florida College of Medicine, Jacksonville, FL, USA.
FAU - Lyons, Brittany
AU  - Lyons B
AUID- ORCID: 0000-0002-8129-9723
AD  - 1 Department of Internal Medicine, University of Florida College of Medicine, 
      Jacksonville, FL, USA.
FAU - Cury, James
AU  - Cury J
AD  - 2 Department of Pulmonary Disease and Critical Care Medicine, University of 
      Florida College of Medicine, Jacksonville, FL, USA.
FAU - Seeram, Vandana
AU  - Seeram V
AD  - 2 Department of Pulmonary Disease and Critical Care Medicine, University of 
      Florida College of Medicine, Jacksonville, FL, USA.
LA  - eng
PT  - Case Reports
DEP - 20171024
PL  - United States
TA  - Pulm Circ
JT  - Pulmonary circulation
JID - 101557243
PMC - PMC5703128
OTO - NOTNLM
OT  - bosutinib
OT  - dasatinib
OT  - pleural effusions
OT  - pulmonary arterial hypertension
EDAT- 2017/09/16 06:00
MHDA- 2017/09/16 06:01
PMCR- 2017/10/24
CRDT- 2017/09/16 06:00
PHST- 2017/09/16 06:00 [pubmed]
PHST- 2017/09/16 06:01 [medline]
PHST- 2017/09/16 06:00 [entrez]
PHST- 2017/10/24 00:00 [pmc-release]
AID - 10.1177_2045893217733444 [pii]
AID - 10.1177/2045893217733444 [doi]
PST - ppublish
SO  - Pulm Circ. 2017 Oct-Dec;7(4):808-812. doi: 10.1177/2045893217733444. Epub 2017 
      Oct 24.