PMID- 28914601
OWN - NLM
STAT- MEDLINE
DCOM- 20180423
LR  - 20191210
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Print)
IS  - 0033-8419 (Linking)
VI  - 286
IP  - 2
DP  - 2018 Feb
TI  - Left Ventricular Long-Axis Function Assessed with Cardiac Cine MR Imaging Is an 
      Independent Predictor of All-Cause Mortality in Patients with Reduced Ejection 
      Fraction: A Multicenter Study.
PG  - 452-460
LID - 10.1148/radiol.2017170529 [doi]
AB  - Purpose To evaluate the prognostic value of a simple index of left ventricular 
      (LV) long-axis function-lateral mitral annular plane systolic excursion 
      (MAPSE)-in a large multicenter population of patients with reduced ejection 
      fraction (EF) who were undergoing cardiac magnetic resonance (MR) imaging. 
      Materials and Methods This retrospective study included 1040 consecutive patients 
      (mean age, 59.5 years +/- 15.8) at four U.S. medical centers who were undergoing 
      cardiac MR imaging for assessment of LV dysfunction with EF less than 50%. 
      Lateral MAPSE was measured in the four-chamber cine view. The primary end point 
      was all-cause death. Cox proportional hazards regression modeling was used to 
      examine the independent association between lateral MAPSE and death. The 
      incremental prognostic value of lateral MAPSE was assessed in nested models. 
      Results During a median follow-up of 4.4 years, 132 patients died. With 
      Kaplan-Meier analysis, the risk of death increased significantly with decreasing 
      tertiles of lateral MAPSE (log-rank P = .0001). Patients with relatively 
      preserved lateral MAPSE (>9 mm) had very few deaths, regardless of whether their 
      EF was above or below 35%. Patients with late gadolinium enhancement (LGE) and 
      low lateral MAPSE had significantly reduced survival compared to those with LGE 
      and high lateral MAPSE (log-rank P < .0001). Lateral MAPSE was independently 
      associated with risk of death after adjustment for clinical and imaging risk 
      factors, which were univariate predictors (age, body mass index, diabetes, LV 
      end-diastolic volume index, LGE, EF) (hazard ratio = 2.051 per mm decrease; 95% 
      confidence interval [CI]: 1.520, 2.768; P < .001). Inclusion of lateral MAPSE in 
      this model resulted in significant improvement in model fit (likelihood ratio 
      test P < .0001) and C statistic (increasing from 0.675 to 0.844; P < .0001). 
      Continuous net reclassification improvement was 1.036 (95% CI: 0.878, 1.194). 
      Conclusion Lateral MAPSE measured during routine cine cardiac MR imaging is a 
      significant independent predictor of mortality in patients with LV dysfunction, 
      incremental to common clinical and cardiac MR risk factors-including EF and LGE. 
      ((c)) RSNA, 2017.
FAU - Romano, Simone
AU  - Romano S
AD  - From the Division of Cardiology, Department of Medicine, University of Illinois 
      at Chicago, 840 S Wood St, M/C 715, Suite 920 S, Chicago, IL 60612 (S.R., J.J., 
      A.F.F.); Department of Medicine, University of Verona, Verona, Italy (S.R.); 
      Division of Cardiology, Department of Medicine, Duke University, Durham, NC 
      (R.M.J., R.J.K., H.W.K., I.K., A.F.F.); Department of Cardiology, New York 
      Methodist Hospital, Brooklyn, NY (J.F.H.); and Houston Methodist DeBakey Heart & 
      Vascular Center, Houston, Tex (D.J.S.).
FAU - Judd, Robert M
AU  - Judd RM
AD  - From the Division of Cardiology, Department of Medicine, University of Illinois 
      at Chicago, 840 S Wood St, M/C 715, Suite 920 S, Chicago, IL 60612 (S.R., J.J., 
      A.F.F.); Department of Medicine, University of Verona, Verona, Italy (S.R.); 
      Division of Cardiology, Department of Medicine, Duke University, Durham, NC 
      (R.M.J., R.J.K., H.W.K., I.K., A.F.F.); Department of Cardiology, New York 
      Methodist Hospital, Brooklyn, NY (J.F.H.); and Houston Methodist DeBakey Heart & 
      Vascular Center, Houston, Tex (D.J.S.).
FAU - Kim, Raymond J
AU  - Kim RJ
AD  - From the Division of Cardiology, Department of Medicine, University of Illinois 
      at Chicago, 840 S Wood St, M/C 715, Suite 920 S, Chicago, IL 60612 (S.R., J.J., 
      A.F.F.); Department of Medicine, University of Verona, Verona, Italy (S.R.); 
      Division of Cardiology, Department of Medicine, Duke University, Durham, NC 
      (R.M.J., R.J.K., H.W.K., I.K., A.F.F.); Department of Cardiology, New York 
      Methodist Hospital, Brooklyn, NY (J.F.H.); and Houston Methodist DeBakey Heart & 
      Vascular Center, Houston, Tex (D.J.S.).
FAU - Kim, Han W
AU  - Kim HW
AD  - From the Division of Cardiology, Department of Medicine, University of Illinois 
      at Chicago, 840 S Wood St, M/C 715, Suite 920 S, Chicago, IL 60612 (S.R., J.J., 
      A.F.F.); Department of Medicine, University of Verona, Verona, Italy (S.R.); 
      Division of Cardiology, Department of Medicine, Duke University, Durham, NC 
      (R.M.J., R.J.K., H.W.K., I.K., A.F.F.); Department of Cardiology, New York 
      Methodist Hospital, Brooklyn, NY (J.F.H.); and Houston Methodist DeBakey Heart & 
      Vascular Center, Houston, Tex (D.J.S.).
FAU - Klem, Igor
AU  - Klem I
AD  - From the Division of Cardiology, Department of Medicine, University of Illinois 
      at Chicago, 840 S Wood St, M/C 715, Suite 920 S, Chicago, IL 60612 (S.R., J.J., 
      A.F.F.); Department of Medicine, University of Verona, Verona, Italy (S.R.); 
      Division of Cardiology, Department of Medicine, Duke University, Durham, NC 
      (R.M.J., R.J.K., H.W.K., I.K., A.F.F.); Department of Cardiology, New York 
      Methodist Hospital, Brooklyn, NY (J.F.H.); and Houston Methodist DeBakey Heart & 
      Vascular Center, Houston, Tex (D.J.S.).
FAU - Heitner, John F
AU  - Heitner JF
AD  - From the Division of Cardiology, Department of Medicine, University of Illinois 
      at Chicago, 840 S Wood St, M/C 715, Suite 920 S, Chicago, IL 60612 (S.R., J.J., 
      A.F.F.); Department of Medicine, University of Verona, Verona, Italy (S.R.); 
      Division of Cardiology, Department of Medicine, Duke University, Durham, NC 
      (R.M.J., R.J.K., H.W.K., I.K., A.F.F.); Department of Cardiology, New York 
      Methodist Hospital, Brooklyn, NY (J.F.H.); and Houston Methodist DeBakey Heart & 
      Vascular Center, Houston, Tex (D.J.S.).
FAU - Shah, Dipan J
AU  - Shah DJ
AD  - From the Division of Cardiology, Department of Medicine, University of Illinois 
      at Chicago, 840 S Wood St, M/C 715, Suite 920 S, Chicago, IL 60612 (S.R., J.J., 
      A.F.F.); Department of Medicine, University of Verona, Verona, Italy (S.R.); 
      Division of Cardiology, Department of Medicine, Duke University, Durham, NC 
      (R.M.J., R.J.K., H.W.K., I.K., A.F.F.); Department of Cardiology, New York 
      Methodist Hospital, Brooklyn, NY (J.F.H.); and Houston Methodist DeBakey Heart & 
      Vascular Center, Houston, Tex (D.J.S.).
FAU - Jue, Jennifer
AU  - Jue J
AD  - From the Division of Cardiology, Department of Medicine, University of Illinois 
      at Chicago, 840 S Wood St, M/C 715, Suite 920 S, Chicago, IL 60612 (S.R., J.J., 
      A.F.F.); Department of Medicine, University of Verona, Verona, Italy (S.R.); 
      Division of Cardiology, Department of Medicine, Duke University, Durham, NC 
      (R.M.J., R.J.K., H.W.K., I.K., A.F.F.); Department of Cardiology, New York 
      Methodist Hospital, Brooklyn, NY (J.F.H.); and Houston Methodist DeBakey Heart & 
      Vascular Center, Houston, Tex (D.J.S.).
FAU - Farzaneh-Far, Afshin
AU  - Farzaneh-Far A
AD  - From the Division of Cardiology, Department of Medicine, University of Illinois 
      at Chicago, 840 S Wood St, M/C 715, Suite 920 S, Chicago, IL 60612 (S.R., J.J., 
      A.F.F.); Department of Medicine, University of Verona, Verona, Italy (S.R.); 
      Division of Cardiology, Department of Medicine, Duke University, Durham, NC 
      (R.M.J., R.J.K., H.W.K., I.K., A.F.F.); Department of Cardiology, New York 
      Methodist Hospital, Brooklyn, NY (J.F.H.); and Houston Methodist DeBakey Heart & 
      Vascular Center, Houston, Tex (D.J.S.).
LA  - eng
GR  - R01 HL064726/HL/NHLBI NIH HHS/United States
GR  - R42 HL117397/HL/NHLBI NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20170914
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Magnetic Resonance Angiography
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Stroke Volume/physiology
MH  - Ventricular Dysfunction, Left/*mortality/physiopathology
PMC - PMC5790302
EDAT- 2017/09/16 06:00
MHDA- 2018/04/24 06:00
PMCR- 2019/02/01
CRDT- 2017/09/16 06:00
PHST- 2017/09/16 06:00 [pubmed]
PHST- 2018/04/24 06:00 [medline]
PHST- 2017/09/16 06:00 [entrez]
PHST- 2019/02/01 00:00 [pmc-release]
AID - 10.1148/radiol.2017170529 [doi]
PST - ppublish
SO  - Radiology. 2018 Feb;286(2):452-460. doi: 10.1148/radiol.2017170529. Epub 2017 Sep 
      14.