PMID- 28915139 OWN - NLM STAT- MEDLINE DCOM- 20180614 LR - 20180614 IS - 1558-2035 (Electronic) IS - 1558-2027 (Linking) VI - 18 IP - 11 DP - 2017 Nov TI - Left and right ventricular morphology, function and late gadolinium enhancement extent and localization change with different clinical presentation of acute myocarditis Data from the ITAlian multicenter study on MYocarditis (ITAMY). PG - 881-887 LID - 10.2459/JCM.0000000000000574 [doi] AB - AIMS: Poor data exist about cardiac magnetic resonance (CMR) findings in a large sample of acute myocarditis with different clinical presentations (heart failure, arrhythmias, and infarct-like presentation). METHODS: Five hundred and forty-three in-patients with a clinical suspected of acute myocarditis confirmed by CMR were enrolled. The clinical indications to perform CMR were chest pain and/or dyspnea and/or palpitations, or effort intolerance/malaise in the last month; elevated troponin and/or new ventricular dysfunction, and/or new ECG abnormalities; and suspected inflammatory cause. CMR examination has permitted to identify epicardial and mid-layer distribution of late gadolinium enhancement (LGE) and to quantify left ventricular (LV) and right ventricular (RV) volumes, and ejection fraction. RESULTS: According to the main clinical pattern of presentation, three groups were categorized: heart failure (heart failure group; 35 patients, 6.4%), arrhythmias (arrhythmias group; 24 patients, 4.4%), and infarct-like (infarct-like group, 484 patients, 89.2%).Heart failure group and arrhythmias group had significantly higher LV volumes and number of LGE segments and lower LV and RV ejection fraction than the infarct-like group.Epicardial LGE in the LV inferolateral wall was the most frequent LGE location in each group. Mid-layer LV septal LGE showed a greater prevalence in the heart failure (52%) and arrhythmias (47%) groups than in the infarct-like group (27%, P < 0.0001). CONCLUSION: In patients with CMR-detected acute myocarditis, heart failure, and arrhythmias have both a higher prevalence of LV and RV dysfunction, segments with LGE, and septal LGE with respect to the infarct-like group. FAU - Di Bella, Gianluca AU - Di Bella G AD - aClinical and Experimental Department of Medicine, University of Messina, Messina bCardiac Department, Vannini Hospital Rome, Roma cRadiology Department, Humanitas Research Hospital, I.R.C.C.S., Milan dDivision of Cardiology, Villa dei Fiori, Napoli, Italy eMount Sinai School of Medicine, New York, New York, USA fSection of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa gU.O. Cardiologia e UTIC, ASST Monza, P.O. Desio, Desio hGabriele Monasterio Foundation-CNR Region Toscana, Pisa iCardiology Department, Policlinico Casilino, Rome jCardiac Department, Centro cardiologico Monzino, Milano kDivision of Cardiology, Department of Cardiac, Thoracic, and Vascular Sciences, University of Padua, Padua lRadiological Department, European Hospital, Roma mDepartment of Advanced Biomedical Sciences, Federico II University, Naples, Italy. FAU - Camastra, Giovanni AU - Camastra G FAU - Monti, Lorenzo AU - Monti L FAU - Dellegrottaglie, Santo AU - Dellegrottaglie S FAU - Piaggi, Paolo AU - Piaggi P FAU - Moro, Claudio AU - Moro C FAU - Pepe, Alessia AU - Pepe A FAU - Lanzillo, Chiara AU - Lanzillo C FAU - Pontone, Gianluca AU - Pontone G FAU - Perazzolo Marra, Martina AU - Perazzolo Marra M FAU - Di Roma, Mauro AU - Di Roma M FAU - Scatteia, Alessandra AU - Scatteia A FAU - Aquaro, Giovanni D AU - Aquaro GD CN - working group 'Cardiac Magnetic Resonance' of the Italian Society of Cardiology LA - eng PT - Journal Article PT - Multicenter Study PL - United States TA - J Cardiovasc Med (Hagerstown) JT - Journal of cardiovascular medicine (Hagerstown, Md.) JID - 101259752 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Adult MH - Arrhythmias, Cardiac/*epidemiology/pathology MH - Contrast Media/administration & dosage MH - Female MH - Gadolinium/administration & dosage MH - Heart Failure/*epidemiology/pathology MH - Heart Ventricles/*diagnostic imaging MH - Humans MH - Italy MH - Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Myocarditis/*complications/diagnostic imaging MH - Myocardium/*pathology MH - Stroke Volume MH - Ventricular Function, Left MH - Young Adult EDAT- 2017/09/16 06:00 MHDA- 2018/06/15 06:00 CRDT- 2017/09/16 06:00 PHST- 2017/09/16 06:00 [pubmed] PHST- 2018/06/15 06:00 [medline] PHST- 2017/09/16 06:00 [entrez] AID - 10.2459/JCM.0000000000000574 [doi] PST - ppublish SO - J Cardiovasc Med (Hagerstown). 2017 Nov;18(11):881-887. doi: 10.2459/JCM.0000000000000574.