PMID- 28915320
OWN - NLM
STAT- MEDLINE
DCOM- 20180511
LR  - 20200306
IS  - 2040-4603 (Electronic)
IS  - 2040-4603 (Linking)
VI  - 7
IP  - 4
DP  - 2017 Sep 12
TI  - Adipose Tissue as a Site of Toxin Accumulation.
PG  - 1085-1135
LID - 10.1002/cphy.c160038 [doi]
AB  - We examine the role of adipose tissue, typically considered an energy storage 
      site, as a potential site of toxicant accumulation. Although the production of 
      most persistent organic pollutants (POPs) was banned years ago, these toxicants 
      persist in the environment due to their resistance to biodegradation and 
      widespread distribution in various environmental forms (e.g., vapor, sediment, 
      and water). As a result, human exposure to these toxicants is inevitable. Largely 
      due to their lipophilicity, POPs bioaccumulate in adipose tissue, resulting in 
      greater body burdens of these environmental toxicants with obesity. POPs of major 
      concern include polychlorinated biphenyls (PCBs), polychlorinated 
      dibenzo-p-dioxins and furans (PCDDs/PCDFs), and polybrominated biphenyls and 
      diphenyl ethers (PBBs/PBDEs), among other organic compounds. In this review, we 
      (i) highlight the physical characteristics of toxicants that enable them to 
      partition into and remain stored in adipose tissue, (ii) discuss the specific 
      mechanisms of action by which these toxicants act to influence adipocyte 
      function, and (iii) review associations between POP exposures and the development 
      of obesity and diabetes. An area of controversy relates to the relative potential 
      beneficial versus hazardous health effects of toxicant sequestration in adipose 
      tissue. (c) 2017 American Physiological Society. Compr Physiol 7:1085-1135, 2017.
CI  - Copyright (c) 2017 John Wiley & Sons, Inc.
FAU - Jackson, Erin
AU  - Jackson E
AD  - Department of Pharmacology and Nutritional Sciences, University of Kentucky, 
      Lexington, Kentucky, USA.
FAU - Shoemaker, Robin
AU  - Shoemaker R
AD  - Department of Pharmacology and Nutritional Sciences, University of Kentucky, 
      Lexington, Kentucky, USA.
FAU - Larian, Nika
AU  - Larian N
AD  - Department of Pharmacology and Nutritional Sciences, University of Kentucky, 
      Lexington, Kentucky, USA.
FAU - Cassis, Lisa
AU  - Cassis L
AD  - Department of Pharmacology and Nutritional Sciences, University of Kentucky, 
      Lexington, Kentucky, USA.
LA  - eng
GR  - P42 ES007380/ES/NIEHS NIH HHS/United States
GR  - T32 DK007778/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20170912
PL  - United States
TA  - Compr Physiol
JT  - Comprehensive Physiology
JID - 101574442
RN  - 0 (Dioxins and Dioxin-like Compounds)
RN  - 0 (Environmental Pollutants)
SB  - IM
EIN - Compr Physiol. 2018 Jun 18;8(3):1251. PMID: 29978893
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Diabetes Mellitus/*etiology
MH  - Dioxins and Dioxin-like Compounds/chemistry/pharmacokinetics/*toxicity
MH  - Environmental Pollutants/chemistry/pharmacokinetics/*toxicity
MH  - Humans
MH  - Obesity/*etiology
PMC - PMC6101675
MID - NIHMS966074
EDAT- 2017/09/16 06:00
MHDA- 2018/05/12 06:00
PMCR- 2018/09/12
CRDT- 2017/09/16 06:00
PHST- 2017/09/16 06:00 [entrez]
PHST- 2017/09/16 06:00 [pubmed]
PHST- 2018/05/12 06:00 [medline]
PHST- 2018/09/12 00:00 [pmc-release]
AID - 10.1002/cphy.c160038 [doi]
PST - epublish
SO  - Compr Physiol. 2017 Sep 12;7(4):1085-1135. doi: 10.1002/cphy.c160038.