PMID- 28915410 OWN - NLM STAT- MEDLINE DCOM- 20180521 LR - 20180521 IS - 1878-5905 (Electronic) IS - 0142-9612 (Linking) VI - 146 DP - 2017 Nov TI - AIEgens for biological process monitoring and disease theranostics. PG - 115-135 LID - S0142-9612(17)30567-7 [pii] LID - 10.1016/j.biomaterials.2017.09.004 [doi] AB - Biological processes are of great significance for the normal physiological functions of living organisms and closely related to the health. Monitoring of biological processes and diagnosis of diseases based on fluorescent techniques would provide comprehensive insight into mechanism of life and pathogenesis of diseases, precisely guiding therapeutic effect in theranostics. It largely relied on fluorophores with the properties of excellent photostability, large Stokes shift, high signal-to-noise ratio and free of aggregation-caused quenching (ACQ) effect. Luminogens with aggregation-induced emission characteristic (AIEgens) could serve as superior agents for biological process monitoring and disease theranostics. Herein, we review the recent results in the aspects of monitoring biological processes such as autophagy, mitophagy, mitochondrion-related dynamics, cell mitotic, long-term cellular tracing and apoptosis as well as the diagnosis of related diseases based on AIEgens in real time. As part of AIEgens and AIEgen-based nanoparticles with the functionalities of drugs, photosensitizers and adjuvants accompanied with imaging, they exhibit huge potential in theranostic systems for image-guided chemotherapy, photodynamic therapy, radiotherapy and so on. Collectively, these examples show the potentials of AIEgens for understanding disease pathogenesis, for drug development and evaluation, and for clinical disease diagnosis and therapy. Future research efforts focused on developing long-wavelength excitable and phosphorescence-emissive AIEgens with improved depth-penetration and minimized background interference for fluorescence and photoacoustic imaging, will extend the potential applications of AIEgens in in vivo. CI - Copyright (c) 2017 Elsevier Ltd. All rights reserved. FAU - Gu, Xinggui AU - Gu X AD - Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Department of Chemistry, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST-Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057, China; Beijing Advanced Innovation Center for Soft Matter Science and Engineering (BAICAS), Beijing University of Chemical Technology, Beijing, 100029, China. FAU - Kwok, Ryan T K AU - Kwok RTK AD - Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Department of Chemistry, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST-Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057, China. FAU - Lam, Jacky W Y AU - Lam JWY AD - Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Department of Chemistry, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST-Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057, China. FAU - Tang, Ben Zhong AU - Tang BZ AD - Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction, Department of Chemistry, Institute for Advanced Study, Institute of Molecular Functional Materials, State Key Laboratory of Molecular Neuroscience, Division of Life Science, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong; Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST-Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057, China; Guangdong Innovative Research Team, SCUT-HKUST Joint Research Laboratory, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou, 510640, China. Electronic address: tangbenz@ust.hk. LA - eng PT - Journal Article PT - Review DEP - 20170904 PL - Netherlands TA - Biomaterials JT - Biomaterials JID - 8100316 RN - 0 (Fluorescent Dyes) SB - IM MH - Fluorescent Dyes MH - Humans MH - Nanoparticles/chemistry MH - Optical Imaging MH - Photochemotherapy MH - Signal-To-Noise Ratio MH - *Theranostic Nanomedicine OTO - NOTNLM OT - AIE OT - Aggregation-induced emission OT - Biological process OT - Diagnosis OT - Theranostics EDAT- 2017/09/16 06:00 MHDA- 2018/05/22 06:00 CRDT- 2017/09/16 06:00 PHST- 2017/06/29 00:00 [received] PHST- 2017/08/29 00:00 [revised] PHST- 2017/09/02 00:00 [accepted] PHST- 2017/09/16 06:00 [pubmed] PHST- 2018/05/22 06:00 [medline] PHST- 2017/09/16 06:00 [entrez] AID - S0142-9612(17)30567-7 [pii] AID - 10.1016/j.biomaterials.2017.09.004 [doi] PST - ppublish SO - Biomaterials. 2017 Nov;146:115-135. doi: 10.1016/j.biomaterials.2017.09.004. Epub 2017 Sep 4.