PMID- 28918317 OWN - NLM STAT- MEDLINE DCOM- 20171010 LR - 20171010 IS - 1873-376X (Electronic) IS - 1570-0232 (Linking) VI - 1064 DP - 2017 Oct 1 TI - Bithionol residue analysis in animal-derived food products by an effective and rugged extraction method coupled with liquid chromatography-tandem mass spectrometry. PG - 100-108 LID - S1570-0232(17)31141-8 [pii] LID - 10.1016/j.jchromb.2017.08.035 [doi] AB - Herein, we developed a simple analytical procedure for the quantitation of bithionol residues in animal-derived food products such as porcine muscle, eggs, milk, eel, flatfish, and shrimp using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction method coupled with liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI(+)/MS-MS). Samples were extracted with 0.1% solution of formic acid in acetonitrile and the extract was purified using a C18 sorbent. Separation was performed on a Waters XBridge C18 reversed-phase analytical column using 0.1% solution of formic acid/acetonitrile as the mobile phase. Six-point matrix-matched calibration indicated good linearity, with the calculated coefficients of determination (R(2)) being>/=0.9813. Intra- and inter-day recoveries (determined at spiking levels equivalent to 1xand 2xthe limit of quantitation (0.25mug/kg)) ranged between 80.0 and 94.0%, with the corresponding relative standard deviations (RSDs) being