PMID- 28919104
OWN - NLM
STAT- MEDLINE
DCOM- 20190123
LR  - 20211204
IS  - 2212-1692 (Electronic)
IS  - 1875-9572 (Linking)
VI  - 59
IP  - 3
DP  - 2018 Jun
TI  - Elevated urinary monocyte chemoattractant protein-1 levels in children with 
      Henoch-Schonlein purpura nephritis.
PG  - 238-243
LID - S1875-9572(16)30113-9 [pii]
LID - 10.1016/j.pedneo.2017.08.008 [doi]
AB  - BACKGROUND: Chemokine monocyte chemoattractant protein-1 (MCP-1) has been proved 
      as a potential urinary biomarker in nephropathies. The aim of this study was to 
      investigate the urinary monocyte chemoattractant protein-1 (MCP-1) levels and 
      clinical significance in Henoch-Schonlein purpura (HSP) children with and without 
      nephritis and determine the association of MCP-1 with proteinuria. METHODS: A 
      total of 261 HSP children-with or without nephritis-and 84 healthy control 
      children were enrolled in this study. Of these, 126 HSP nephritis (HSPN) children 
      were subdivided into three groups according to total urine protein in 24 h (TUP): 
      Group A, mild proteinuria group with TUP <25 mg/kg; Group B, moderate proteinuria 
      group with TUP >/=25 mg/kg and <50 mg/kg; Group C, severe proteinuria group with 
      TUP >/=50 mg/kg. Urinary MCP-1 levels were determined by ELISA. Levels of serum 
      creatinine (Cr), blood urea nitrogen (BUN), urinary alpha(1)-micro globulin 
      (alpha(1)-MG), micro-albumin (mAlb), immunoglobulin G (IgG), transferrin (TRF) and 
      TUP were performed to determine their associations with MCP-1. RESULTS: Urinary 
      MCP-1 was significantly higher in HSPN group in comparison with HSP group and 
      controls (P < 0.05), but no significant difference was found between the HSP 
      group and the healthy group (P > 0.05). The levels of urinary MCP-1 increased in 
      parallel to the enhancement of total urine protein in 24 h in HSPN patients. 
      There were statistically significant differences among these three groups of HSPN 
      children (p < 0.05). Urinary MCP-1 correlated positively with urinary alpha(1)-MG, 
      mAlb, IgG, TRF and TUP in HSPN, whereas no correlation was observed with serum Cr 
      and BUN. CONCLUSIONS: MCP-1 was elevated in children with HSPN and correlated 
      with proteinuria. Urinary MCP-1 could be used as a suitable, non-invasive 
      biomarker to provide valuable information not only for the diagnosis of HSPN, but 
      also for evaluation of severity of renal damage.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Wang, Jiapei
AU  - Wang J
AD  - Department of Pediatric Rheumatology and Immunology, Ningbo Women and Children's 
      Hospital, 339 Liuting Street, Ningbo, Zhejiang 315000, China.
FAU - Ying, Qianqian
AU  - Ying Q
AD  - Medicine School, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315000, 
      China.
FAU - Zhong, Shiling
AU  - Zhong S
AD  - Department of Pediatric Rheumatology and Immunology, Ningbo Women and Children's 
      Hospital, 339 Liuting Street, Ningbo, Zhejiang 315000, China.
FAU - Chen, Yuanling
AU  - Chen Y
AD  - Department of Pediatric Rheumatology and Immunology, Ningbo Women and Children's 
      Hospital, 339 Liuting Street, Ningbo, Zhejiang 315000, China.
FAU - Di, Yazhen
AU  - Di Y
AD  - Department of Pediatric Rheumatology and Immunology, Ningbo Women and Children's 
      Hospital, 339 Liuting Street, Ningbo, Zhejiang 315000, China. Electronic address: 
      dyz028sci@163.com.
FAU - Dai, Xiahua
AU  - Dai X
AD  - Department of Pediatric Rheumatology and Immunology, Ningbo Women and Children's 
      Hospital, 339 Liuting Street, Ningbo, Zhejiang 315000, China.
FAU - Zheng, Jika
AU  - Zheng J
AD  - Department of Pediatric Rheumatology and Immunology, Ningbo Women and Children's 
      Hospital, 339 Liuting Street, Ningbo, Zhejiang 315000, China.
FAU - Shen, Mengjiao
AU  - Shen M
AD  - Medicine School, Ningbo University, 818 Fenghua Road, Ningbo, Zhejiang 315000, 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170826
PL  - Singapore
TA  - Pediatr Neonatol
JT  - Pediatrics and neonatology
JID - 101484755
RN  - 0 (Alpha-Globulins)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (alpha-1 serum globulin)
SB  - IM
MH  - Adolescent
MH  - Alpha-Globulins/urine
MH  - Chemokine CCL2/*urine
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - IgA Vasculitis/*urine
MH  - Male
MH  - Nephritis/*urine
MH  - Proteinuria/urine
OTO - NOTNLM
OT  - Henoch-Schonlein purpura nephritis
OT  - children
OT  - monocyte chemoattractant protein-1
OT  - proteinuria
EDAT- 2017/09/19 06:00
MHDA- 2019/01/24 06:00
CRDT- 2017/09/19 06:00
PHST- 2016/08/27 00:00 [received]
PHST- 2017/05/19 00:00 [revised]
PHST- 2017/08/22 00:00 [accepted]
PHST- 2017/09/19 06:00 [pubmed]
PHST- 2019/01/24 06:00 [medline]
PHST- 2017/09/19 06:00 [entrez]
AID - S1875-9572(16)30113-9 [pii]
AID - 10.1016/j.pedneo.2017.08.008 [doi]
PST - ppublish
SO  - Pediatr Neonatol. 2018 Jun;59(3):238-243. doi: 10.1016/j.pedneo.2017.08.008. Epub 
      2017 Aug 26.