PMID- 28921568
OWN - NLM
STAT- MEDLINE
DCOM- 20180102
LR  - 20211204
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 144
IP  - 1
DP  - 2018 Jan
TI  - Neuronal activity-dependent local activation of dendritic unfolded protein 
      response promotes expression of brain-derived neurotrophic factor in cell soma.
PG  - 35-49
LID - 10.1111/jnc.14221 [doi]
AB  - Unfolded protein response (UPR) has roles not only in resolving the accumulation 
      of unfolded proteins owing to endoplasmic reticulum (ER) stress, but also in 
      regulation of cellular physiological functions. ER stress transducers providing 
      the branches of UPR signaling are known to localize in distal dendritic ER of 
      neurons. These reports suggest that local activation of UPR branches may produce 
      integrated outputs for distant communication, and allow regulation of local 
      events in highly polarized neurons. Here, we demonstrated that synaptic activity- 
      and brain-derived neurotrophic factor (BDNF)-dependent local activation of UPR 
      signaling could be associated with dendritic functions through retrograde signal 
      propagation by using murine neuroblastoma cell line, Neuro-2A and primary 
      cultured hippocampal neurons derived from postnatal day 0 litter C57BL/6 mice. ER 
      stress transducer, inositol-requiring kinase 1 (IRE1), was activated at 
      postsynapses in response to excitatory synaptic activation. Activated dendritic 
      IRE1 accelerated accumulation of the downstream transcription factor, 
      x-box-binding protein 1 (XBP1), in the nucleus. Interestingly, excitatory 
      synaptic activation-dependent up-regulation of XBP1 directly facilitated 
      transcriptional activation of BDNF. BDNF in turn drove its own expression via 
      IRE1-XBP1 pathway in a protein kinase A-dependent manner. Exogenous treatment 
      with BDNF promoted extension and branching of dendrites through the protein 
      kinase A-IRE1-XBP1 cascade. Taken together, our findings indicate novel 
      mechanisms for communication between soma and distal sites of polarized neurons 
      that are coordinated by local activation of IRE1-XBP1 signaling. Synaptic 
      activity- and BDNF-dependent distinct activation of dendritic IRE1-XBP1 cascade 
      drives BDNF expression in cell soma and may be involved in dendritic extension. 
      Cover Image for this issue: doi. 10.1111/jnc.14159.
CI  - (c) 2017 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd 
      on behalf of International Society for Neurochemistry.
FAU - Saito, Atsushi
AU  - Saito A
AUID- ORCID: 0000-0003-2425-3371
AD  - Department of Stress Protein Processing, Institute of Biomedical & Health 
      Sciences, Hiroshima University, Minami-ku, Hiroshima, Japan.
FAU - Cai, Longjie
AU  - Cai L
AD  - Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima 
      University, Minami-ku, Hiroshima, Japan.
FAU - Matsuhisa, Koji
AU  - Matsuhisa K
AD  - Department of Stress Protein Processing, Institute of Biomedical & Health 
      Sciences, Hiroshima University, Minami-ku, Hiroshima, Japan.
FAU - Ohtake, Yosuke
AU  - Ohtake Y
AD  - Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima 
      University, Minami-ku, Hiroshima, Japan.
FAU - Kaneko, Masayuki
AU  - Kaneko M
AD  - Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima 
      University, Minami-ku, Hiroshima, Japan.
FAU - Kanemoto, Soshi
AU  - Kanemoto S
AD  - Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima 
      University, Minami-ku, Hiroshima, Japan.
FAU - Asada, Rie
AU  - Asada R
AD  - Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima 
      University, Minami-ku, Hiroshima, Japan.
FAU - Imaizumi, Kazunori
AU  - Imaizumi K
AD  - Department of Biochemistry, Institute of Biomedical & Health Sciences, Hiroshima 
      University, Minami-ku, Hiroshima, Japan.
LA  - eng
PT  - Journal Article
DEP - 20171016
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Proteins)
RN  - 0 (X-Box Binding Protein 1)
RN  - 0 (Xbp1 protein, mouse)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - EC 2.7.1.- (Ern2 protein, mouse)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics
MH  - Cell Line, Tumor
MH  - Cell Nucleus/metabolism
MH  - Cyclic AMP-Dependent Protein Kinases/physiology
MH  - Dendrites/metabolism
MH  - Endoplasmic Reticulum/metabolism
MH  - Glutamic Acid/pharmacology
MH  - Hippocampus/cytology
MH  - Membrane Proteins/biosynthesis/genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuroblastoma
MH  - Neurons/*metabolism
MH  - Protein Serine-Threonine Kinases/biosynthesis/genetics
MH  - Signal Transduction/physiology
MH  - Synapses/physiology
MH  - *Unfolded Protein Response
MH  - X-Box Binding Protein 1/metabolism
PMC - PMC5765399
OTO - NOTNLM
OT  - BDNF
OT  - IRE1
OT  - XBP1
OT  - dendrite
OT  - endoplasmic reticulum stress
OT  - unfolded protein response
EDAT- 2017/09/19 06:00
MHDA- 2018/01/03 06:00
PMCR- 2018/01/12
CRDT- 2017/09/19 06:00
PHST- 2017/06/29 00:00 [received]
PHST- 2017/08/21 00:00 [revised]
PHST- 2017/09/08 00:00 [accepted]
PHST- 2017/09/19 06:00 [pubmed]
PHST- 2018/01/03 06:00 [medline]
PHST- 2017/09/19 06:00 [entrez]
PHST- 2018/01/12 00:00 [pmc-release]
AID - JNC14221 [pii]
AID - 10.1111/jnc.14221 [doi]
PST - ppublish
SO  - J Neurochem. 2018 Jan;144(1):35-49. doi: 10.1111/jnc.14221. Epub 2017 Oct 16.