PMID- 28922053
OWN - NLM
STAT- MEDLINE
DCOM- 20180817
LR  - 20181113
IS  - 1933-6969 (Electronic)
IS  - 1933-6950 (Print)
IS  - 1933-6950 (Linking)
VI  - 11
IP  - 6
DP  - 2017 Nov 2
TI  - Distribution and function of voltage-gated sodium channels in the nervous system.
PG  - 534-554
LID - 10.1080/19336950.2017.1380758 [doi]
AB  - Voltage-gated sodium channels (VGSCs) are the basic ion channels for neuronal 
      excitability, which are crucial for the resting potential and the generation and 
      propagation of action potentials in neurons. To date, at least nine distinct 
      sodium channel isoforms have been detected in the nervous system. Recent studies 
      have identified that voltage-gated sodium channels not only play an essential 
      role in the normal electrophysiological activities of neurons but also have a 
      close relationship with neurological diseases. In this study, the latest research 
      findings regarding the structure, type, distribution, and function of VGSCs in 
      the nervous system and their relationship to neurological diseases, such as 
      epilepsy, neuropathic pain, brain tumors, neural trauma, and multiple sclerosis, 
      are reviewed in detail.
FAU - Wang, Jun
AU  - Wang J
AD  - a Department of Neurosurgery , The First Hospital of China Medical University , 
      Shenyang , P.R. China.
FAU - Ou, Shao-Wu
AU  - Ou SW
AD  - a Department of Neurosurgery , The First Hospital of China Medical University , 
      Shenyang , P.R. China.
FAU - Wang, Yun-Jie
AU  - Wang YJ
AD  - a Department of Neurosurgery , The First Hospital of China Medical University , 
      Shenyang , P.R. China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20171108
PL  - United States
TA  - Channels (Austin)
JT  - Channels (Austin, Tex.)
JID - 101321614
RN  - 0 (Voltage-Gated Sodium Channels)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Neurons/*metabolism
MH  - Voltage-Gated Sodium Channels/*metabolism
PMC - PMC5786190
OTO - NOTNLM
OT  - function
OT  - nervous system
OT  - neurological diseases
OT  - voltage-gated sodium channel
EDAT- 2017/09/19 06:00
MHDA- 2018/08/18 06:00
PMCR- 2018/11/08
CRDT- 2017/09/19 06:00
PHST- 2017/09/19 06:00 [pubmed]
PHST- 2018/08/18 06:00 [medline]
PHST- 2017/09/19 06:00 [entrez]
PHST- 2018/11/08 00:00 [pmc-release]
AID - 1380758 [pii]
AID - 10.1080/19336950.2017.1380758 [doi]
PST - ppublish
SO  - Channels (Austin). 2017 Nov 2;11(6):534-554. doi: 10.1080/19336950.2017.1380758. 
      Epub 2017 Nov 8.