PMID- 28922060
OWN - NLM
STAT- MEDLINE
DCOM- 20181003
LR  - 20181004
IS  - 1931-8448 (Electronic)
IS  - 1076-6294 (Linking)
VI  - 24
IP  - 4
DP  - 2018 May
TI  - Risk Factors for Nasal Colonization by Methicillin-Resistant Staphylococci in 
      Healthy Humans in Professional Daily Contact with Companion Animals in Portugal.
PG  - 434-446
LID - 10.1089/mdr.2017.0063 [doi]
AB  - Methicillin-resistant staphylococci (MRS), namely Staphylococcus aureus (MRSA) 
      and Staphylococcus pseudintermedius (MRSP), are opportunistic agents of great 
      importance in human and veterinary medicine. The aims of this study were to 
      investigate the frequency, persistence, and risk factors associated with nasal 
      colonization by MRS in people in daily contact with animals in Portugal. 
      Seventy-nine out of 129 (61.2%) participants were found to be colonized by, at 
      least, one methicillin-resistant (MR) staphylococci species (MR Staphylococcus 
      epidermidis [n = 68], MRSA [n = 19], MR Staphylococcus haemolyticus [n = 7], MRSP 
      [n = 2], and other coagulase-negative staphylococci [n = 4]). Three lineages were 
      identified among the MRSA isolates (n = 7): the major human healthcare clone in 
      Portugal (ST22-t032-IV, n = 3), the livestock-associated MRSA (ST398-t108-V, 
      n = 3), and the New York-/Japan-related clone (ST105-t002-II, n = 1). MRSP 
      isolates belonged to the European clone ST71-II-III. We identified two risk 
      factors for nasal colonization by MRS in healthy humans: (i) being a veterinary 
      professional (veterinarian and veterinary nurse) (p < 0.0001, odds ratio 
      [OR] = 6.369, 95% confidence interval [CI, 2.683-15.122]) and (ii) have contacted 
      with one MRSA- or MRSP-positive animal (p = 0.0361, OR = 2.742, 95% CI 
      [1.067-7.045]). The follow-up study revealed that the majority (85%) remain 
      colonized. This study shows that MRS in veterinary clinical practice is a 
      professional hazard and highlights the need to implement preventive measures to 
      minimize spread.
FAU - Rodrigues, Ana Catarina
AU  - Rodrigues AC
AD  - 1 Laboratory of Antimicrobial and Biocide Resistance, CIISA, Faculty of 
      Veterinary Medicine, University of Lisbon (FMV-UL) , Lisbon, Portugal .
FAU - Belas, Adriana
AU  - Belas A
AD  - 1 Laboratory of Antimicrobial and Biocide Resistance, CIISA, Faculty of 
      Veterinary Medicine, University of Lisbon (FMV-UL) , Lisbon, Portugal .
FAU - Marques, Catia
AU  - Marques C
AD  - 1 Laboratory of Antimicrobial and Biocide Resistance, CIISA, Faculty of 
      Veterinary Medicine, University of Lisbon (FMV-UL) , Lisbon, Portugal .
FAU - Cruz, Luis
AU  - Cruz L
AD  - 2 Hospital Veterinario das Laranjeiras , Lisbon, Portugal .
FAU - Gama, Luis T
AU  - Gama LT
AD  - 3 Animal Genetic Resources, CIISA, Faculty of Veterinary Medicine, University of 
      Lisbon (FMV-UL) , Lisbon, Portugal .
FAU - Pomba, Constanca
AU  - Pomba C
AD  - 1 Laboratory of Antimicrobial and Biocide Resistance, CIISA, Faculty of 
      Veterinary Medicine, University of Lisbon (FMV-UL) , Lisbon, Portugal .
LA  - eng
PT  - Journal Article
DEP - 20170918
PL  - United States
TA  - Microb Drug Resist
JT  - Microbial drug resistance (Larchmont, N.Y.)
JID - 9508567
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Carrier State/microbiology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Livestock/microbiology
MH  - Male
MH  - Methicillin-Resistant Staphylococcus aureus/drug effects/*isolation & 
      purification
MH  - Nasal Cavity/*microbiology
MH  - Nose/*microbiology
MH  - Pets/*microbiology
MH  - Portugal
MH  - Risk Factors
MH  - Staphylococcal Infections/drug therapy/*microbiology/veterinary
MH  - Veterinarians
OTO - NOTNLM
OT  - MRS
OT  - carriage
OT  - mecA
OT  - occupational health
OT  - risk factors
EDAT- 2017/09/19 06:00
MHDA- 2018/10/04 06:00
CRDT- 2017/09/19 06:00
PHST- 2017/09/19 06:00 [pubmed]
PHST- 2018/10/04 06:00 [medline]
PHST- 2017/09/19 06:00 [entrez]
AID - 10.1089/mdr.2017.0063 [pii]
AID - 10.1089/mdr.2017.0063 [doi]
PST - ppublish
SO  - Microb Drug Resist. 2018 May;24(4):434-446. doi: 10.1089/mdr.2017.0063. Epub 2017 
      Sep 18.