PMID- 28922378
OWN - NLM
STAT- MEDLINE
DCOM- 20171013
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 9
DP  - 2017
TI  - Relationships of orientation discrimination threshold and visual acuity with 
      macular lesions in age-related macular degeneration.
PG  - e0185070
LID - 10.1371/journal.pone.0185070 [doi]
LID - e0185070
AB  - PURPOSE: To measure visual acuity and metamorphopsia in patients with age-related 
      macular degeneration (AMD) and to explore their relationship with macular 
      lesions. METHODS: In this cross-sectional study, a total of 32 normal subjects 
      (32 eyes) and 35 AMD patients (35 eyes) were recruited. They were categorized 
      into 4 groups: normal, dry AMD, non-active wet AMD, and active wet AMD. 
      Best-corrected visual acuity (BCVA) was measured using the Early Treatment 
      Diabetic Retinopathy Study protocol. Metamorphopsia was quantified with the 
      orientation discrimination threshold (ODT). Macular lesions, including drusen, 
      sub-retinal fluid (SRF), intra-retinal fluid (IRF), pigmented epithelium 
      detachment (PED), and scarring, were identified with spectral-domain optical 
      coherence tomography (SD-OCT). A linear regression model was established to 
      identify the relationships between the functional and structural changes. 
      RESULTS: BCVA progressively worsened across the normal, dry AMD, non-active wet 
      AMD, and active wet AMD groups (P < 0.001), and ODT increased across the groups 
      (P < 0.001). The correlation between BCVA and ODT varied among the groups. The 
      partial correlation between BCVA and ODT was -0.61 (P < 0.001). Linear regression 
      showed that ODT significantly depended on IRF (beta = 0.61, P < 0.001), SRF (beta = 
      0.34, P = 0.003), and scarring (beta = 0.26, P = 0.050), while BCVA significantly 
      depended only on scarring (beta = -0.52, P < 0.001), and IRF (beta = -0.36, P = 0.016). 
      CONCLUSIONS: From dry AMD to active wet AMD, BCVA gradually worsened while ODT 
      increased. The correlation between BCVA and ODT varied among these groups, 
      indicating that AMD lesions affect them differently. ODT and BCVA should be used 
      concurrently for better monitoring of the disease.
FAU - Fu, Haojie
AU  - Fu H
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Zhang, Bin
AU  - Zhang B
AD  - College of Optometry, Nova Southeastern University, Davie, Florida, United States 
      of America.
FAU - Tong, Jianliang
AU  - Tong J
AD  - Brain Trauma Foundation, New York, New York, United States of America.
FAU - Bedell, Harold
AU  - Bedell H
AD  - College of Optometry, University of Houston, Houston, Texas, United States of 
      America.
FAU - Zhang, Hecheng
AU  - Zhang H
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Yang, Yating
AU  - Yang Y
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Nie, Chaochao
AU  - Nie C
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Luo, Yingdong
AU  - Luo Y
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
FAU - Liu, Xiaoling
AU  - Liu X
AUID- ORCID: 0000-0002-5051-4574
AD  - School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, 
      Zhejiang, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20170918
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - *Macular Degeneration/classification/diagnostic imaging/metabolism
MH  - Male
MH  - Middle Aged
MH  - *Retinal Pigment Epithelium/diagnostic imaging/metabolism
MH  - *Tomography, Optical Coherence
PMC - PMC5602672
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2017/09/19 06:00
MHDA- 2017/10/14 06:00
PMCR- 2017/09/18
CRDT- 2017/09/19 06:00
PHST- 2017/03/17 00:00 [received]
PHST- 2017/09/06 00:00 [accepted]
PHST- 2017/09/19 06:00 [entrez]
PHST- 2017/09/19 06:00 [pubmed]
PHST- 2017/10/14 06:00 [medline]
PHST- 2017/09/18 00:00 [pmc-release]
AID - PONE-D-17-10516 [pii]
AID - 10.1371/journal.pone.0185070 [doi]
PST - epublish
SO  - PLoS One. 2017 Sep 18;12(9):e0185070. doi: 10.1371/journal.pone.0185070. 
      eCollection 2017.