PMID- 28924076
OWN - NLM
STAT- MEDLINE
DCOM- 20190219
LR  - 20190320
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 82
IP  - 2
DP  - 2018 Jan 25
TI  - Third and Fourth Heart Sounds and Myocardial Fibrosis in Hypertrophic 
      Cardiomyopathy.
PG  - 509-516
LID - 10.1253/circj.CJ-17-0650 [doi]
AB  - BACKGROUND: The 4th heart sound (S4) is commonly heard in patients with 
      hypertrophic cardiomyopathy (HCM). The 3rd heart sound (S3) is also audible in 
      HCM patients regardless of the presence or absence of heart failure. These extra 
      heart sounds may be associated with myocardial fibrosis because myocardial 
      fibrosis has been suggested to affect left ventricular 
      compliance.Methods and Results:The present retrospective study evaluated 53 
      consecutive HCM patients with sinus rhythm who had no symptoms of heart failure 
      and underwent an initial assessment including phonocardiography, 
      echocardiography, and late gadolinium enhancement (LGE) magnetic resonance 
      imaging (MRI). S3 was detected on phonocardiography in 13% of all patients, and 
      S4 was recorded in 75% of patients. Patients with S3 had a higher incidence of 
      LGE and larger LGE volumes (86% and 11.5+/-2.4 g/cm, respectively) than patients 
      without S3 (33% and 2.5+/-0.8 g/cm, respectively; P=0.02 and P=0.002). The presence 
      of S4 was not associated with MRI findings, including the incidence of LGE and 
      LGE volume. The diagnostic value of S3 for the detection of LGE was highly 
      specific (97%), with a low sensitivity (29%). CONCLUSIONS: Myocardial fibrosis, 
      as assessed by LGE, was associated with S3 but not with S4 in patients with HCM. 
      These results may contribute to the risk stratification of patients with HCM.
FAU - Sato, Yoshimi
AU  - Sato Y
AD  - Department of Cardiology, Matsushita Memorial Hospital.
FAU - Kawasaki, Tatsuya
AU  - Kawasaki T
AD  - Department of Cardiology, Matsushita Memorial Hospital.
FAU - Honda, Sakiko
AU  - Honda S
AD  - Department of Cardiology, Matsushita Memorial Hospital.
FAU - Harimoto, Kuniyasu
AU  - Harimoto K
AD  - Department of Cardiology, Matsushita Memorial Hospital.
FAU - Miki, Shigeyuki
AU  - Miki S
AD  - Department of Cardiology, Matsushita Memorial Hospital.
FAU - Kamitani, Tadaaki
AU  - Kamitani T
AD  - Department of Cardiology, Matsushita Memorial Hospital.
FAU - Shiraishi, Hirokazu
AU  - Shiraishi H
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto 
      Prefectural University of Medicine.
FAU - Matoba, Satoaki
AU  - Matoba S
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto 
      Prefectural University of Medicine.
LA  - eng
PT  - Journal Article
DEP - 20170916
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiomyopathy, Hypertrophic/*diagnosis/pathology/physiopathology
MH  - Female
MH  - Fibrosis
MH  - Gadolinium
MH  - *Heart Sounds
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Retrospective Studies
MH  - Risk Assessment
OTO - NOTNLM
OT  - 3rd heart sound
OT  - 4th heart sound
OT  - Hypertrophic cardiomyopathy
OT  - Late gadolinium enhancement
OT  - Phonocardiography
EDAT- 2017/09/20 06:00
MHDA- 2019/03/21 06:00
CRDT- 2017/09/20 06:00
PHST- 2017/09/20 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2017/09/20 06:00 [entrez]
AID - 10.1253/circj.CJ-17-0650 [doi]
PST - ppublish
SO  - Circ J. 2018 Jan 25;82(2):509-516. doi: 10.1253/circj.CJ-17-0650. Epub 2017 Sep 
      16.