PMID- 28924365
OWN - NLM
STAT- MEDLINE
DCOM- 20180521
LR  - 20181202
IS  - 1449-1907 (Electronic)
IS  - 1449-1907 (Linking)
VI  - 14
IP  - 10
DP  - 2017
TI  - Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol 
      to the Stress.
PG  - 943-950
LID - 10.7150/ijms.19391 [doi]
AB  - High-altitude retinopathy represents retinal functional changes associated with 
      environmental challenges imposed by hypobaric hypoxia, but the detailed cellular 
      and molecular mechanism underlying this process remains unclear. Our current 
      investigation was to explore the effect of hypobaric hypoxia on the rat retina 
      and determine whether resveratrol has a protective efficacy on the hypoxic damage 
      to the retina. Experiment rats were randomly grouped as the control group, 
      hypoxia group and resveratrol intervention group. The hypoxia group and the 
      resveratrol intervention group were maintained in a low-pressure oxygen cabin, 
      and the resveratrol intervention group was given daily intraperitoneal injections 
      with resveratrol. We found that hypobaric hypoxia increased thioredoxin 1 (Trx1) 
      and thioredoxin 2 (Trx2) expression in retinas, and resveratrol treatment 
      significantly reversed these changes (P < 0.05, P < 0.05 respectively). In 
      comparison with controls, hypoxia upregulated the mRNA expression levels of 
      caspase3 (P < 0.001), caspase9 (P < 0.01), heat shock protein 70 (Hsp70) (P < 
      0.05), heat shock protein 90 (Hsp90) (P < 0.001) and hypoxia-inducible factor-1 
      (HIF-1) (P < 0.05). Resveratrol administration caused a significant decrease in 
      the gene expression of caspase3 (P< 0.001), HSP90 (P < 0.05) and HIF-1 mRNA (P < 
      0.01) as well as an increase in HSP70 mRNA when compared with the hypoxia group. 
      These findings indicated that resveratrol exerted an anti-oxidative role by 
      modulating hypoxia stress- associated genes and an anti-apoptosis role by 
      regulating apoptosis-related cytokines. In conclusion, hypobaric hypoxia may have 
      a pathological impact on rat retinas. The intervention of resveratrol reverses 
      the effect induced by hypobaric hypoxia and elicits a protective response to the 
      stress.
FAU - Xin, Xiaorong
AU  - Xin X
AD  - Department of Ophthalmology, Qinghai Red Cross Hospital, Xining, Qinghai, China.
FAU - Dang, Hong
AU  - Dang H
AD  - Department of Ophthalmology, Qinghai Red Cross Hospital, Xining, Qinghai, China.
FAU - Zhao, Xiaojing
AU  - Zhao X
AD  - Department of Ophthalmology, Qinghai Red Cross Hospital, Xining, Qinghai, China.
FAU - Wang, Haohao
AU  - Wang H
AD  - Department of Ophthalmology, Qinghai Red Cross Hospital, Xining, Qinghai, China.
LA  - eng
PT  - Journal Article
DEP - 20170817
PL  - Australia
TA  - Int J Med Sci
JT  - International journal of medical sciences
JID - 101213954
RN  - 0 (Antioxidants)
RN  - 0 (Cytokines)
RN  - 0 (Stilbenes)
RN  - 0 (Txn1 protein, rat)
RN  - 0 (Txn2 protein, rat)
RN  - 52500-60-4 (Thioredoxins)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Altitude Sickness/complications/drug therapy/*metabolism
MH  - Animals
MH  - Antioxidants/*pharmacology/therapeutic use
MH  - Apoptosis/drug effects
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Humans
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Resveratrol
MH  - Retina/*drug effects/pathology
MH  - Retinal Diseases/etiology/*prevention & control
MH  - Stilbenes/*pharmacology/therapeutic use
MH  - Thioredoxins/metabolism
PMC - PMC5599917
OTO - NOTNLM
OT  - Caspase
OT  - Heat shock protein
OT  - Hypobaric hypoxia
OT  - Hypoxia-inducible factor-1.
OT  - Resveratrol
OT  - Retina
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2017/09/20 06:00
MHDA- 2018/05/22 06:00
PMCR- 2017/01/01
CRDT- 2017/09/20 06:00
PHST- 2017/01/29 00:00 [received]
PHST- 2017/06/28 00:00 [accepted]
PHST- 2017/09/20 06:00 [entrez]
PHST- 2017/09/20 06:00 [pubmed]
PHST- 2018/05/22 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - ijmsv14p0943 [pii]
AID - 10.7150/ijms.19391 [doi]
PST - epublish
SO  - Int J Med Sci. 2017 Aug 17;14(10):943-950. doi: 10.7150/ijms.19391. eCollection 
      2017.