PMID- 28924539
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1311-0160 (Print)
IS  - 2199-5761 (Electronic)
IS  - 1311-0160 (Linking)
VI  - 20
IP  - 1
DP  - 2017 Jun 30
TI  - Genetic Polymorphisms of Hemostatic Factors and Thrombotic Risk in Non BCR-ABL 
      Myeloproliferative Neoplasms: A Pilot Study.
PG  - 35-42
LID - 10.1515/bjmg-2017-0005 [doi]
AB  - The most important complications of Philadelphianegagive (non BCR-ABL) 
      myeloproliferative neoplasms (MPNs) are vascular events. Our aim was to evaluate 
      the effects of single nucleotide polymorphisms (SNPs), platelet glycoproteins 
      (GPs) (Ia/IIa, Ibalpha, IIb/IIIa and VI), von Willebrand factor (vWF), coagulation 
      factor VII (FVII), beta-fibrinogen, and the risk of thrombosis in patients with non 
      BCR-ABL MPNs at the Lithuanian University of Health Sciences. Kaunas, Lithuania. 
      Genotyping was done for 108 patients. The TT genotype of the GP Ia/IIa c.807C>T 
      polymorphism was more frequently found in the group of MPN patients with arterial 
      thrombosis compared to MPN patients who were thrombosis-free [26.5 vs. 11.5%, p = 
      0.049; odds ratio (OR) 2.68; 95% confidence interval (95% CI) 1.01-7.38]. The CT 
      genotype of the beta-fibrinogen c.-148C>T polymorphism occurred more frequently in 
      MPN patients with arterial, and total thrombosis compared to the wild or 
      homozygous genotype (57.7 vs. 40.0 vs. 12.5%; p = 0.027), (64.7 vs. 44.4 vs. 25%; 
      p = 0.032), respectively. The carrier state for the c.-323P10 variant of FVII SNP 
      (summation of P10/10 and P0/10) was more frequent in MPN patients with thrombosis 
      compared to the wild-type genotype carriers (71.4 vs. 43.4%; p = 0.049; OR 3.26; 
      95% CI 1.01-11.31). The coexistence of heterozygous beta-fibrinogen c.-148C>T and 
      FVII c.-323P0/10 SNP, increased the risk of arterial thrombosis (21.1 vs. 3.7%, p 
      = 0.008; OR 6.93; 95% CI 1.38-34.80). The TT genotype of GP Ia/IIa c.807C>T, the 
      CT genotype of beta-fibrinogen c.-148C>T and FVII c.-323P0/10 SNP could be 
      associated with risk of thrombosis in MPN patients.
FAU - Dambrauskiene, R
AU  - Dambrauskiene R
AD  - Department of Oncology and Hematology, Institute of Oncology, Lithuanian 
      University of Health Sciences, Kaunas, Lithuania.
FAU - Gerbutavicius, R
AU  - Gerbutavicius R
AD  - Department of Oncology and Hematology, Institute of Oncology, Lithuanian 
      University of Health Sciences, Kaunas, Lithuania.
FAU - Ugenskiene, R
AU  - Ugenskiene R
AD  - Lithuanian University of Health Sciences, Institute of Oncology, Oncology 
      Research Laboratory, Kaunas, Lithuania.
FAU - Jankauskaite, R
AU  - Jankauskaite R
AD  - Lithuanian University of Health Sciences, Institute of Oncology, Oncology 
      Research Laboratory, Kaunas, Lithuania.
FAU - Savukaityte, A
AU  - Savukaityte A
AD  - Lithuanian University of Health Sciences, Institute of Oncology, Oncology 
      Research Laboratory, Kaunas, Lithuania.
FAU - Simoliuniene, R
AU  - Simoliuniene R
AD  - Department of Physics, Mathematics and Biophysics, Lithuanian University of 
      Health Sciences, Kaunas, Lithuania.
FAU - Rudzianskiene, M
AU  - Rudzianskiene M
AD  - Department of Oncology and Hematology, Institute of Oncology, Lithuanian 
      University of Health Sciences, Kaunas, Lithuania.
FAU - Gerbutaviciene, R
AU  - Gerbutaviciene R
AD  - Department of Drug Technology and Social Pharmacy, Faculty of Pharmacy, 
      Lithuanian University of Health Sciences, Kaunas, Lithuania.
FAU - Juozaityte, E
AU  - Juozaityte E
AD  - Department of Oncology and Hematology, Institute of Oncology, Lithuanian 
      University of Health Sciences, Kaunas, Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20170630
PL  - Poland
TA  - Balkan J Med Genet
JT  - Balkan journal of medical genetics : BJMG
JID - 9806959
PMC - PMC5596820
OTO - NOTNLM
OT  - Genetic polymorphism
OT  - Myeloproliferative neoplasia
OT  - Thrombosis
EDAT- 2017/09/20 06:00
MHDA- 2017/09/20 06:01
PMCR- 2017/06/30
CRDT- 2017/09/20 06:00
PHST- 2017/09/20 06:00 [entrez]
PHST- 2017/09/20 06:00 [pubmed]
PHST- 2017/09/20 06:01 [medline]
PHST- 2017/06/30 00:00 [pmc-release]
AID - bjmg-2017-0005 [pii]
AID - 10.1515/bjmg-2017-0005 [doi]
PST - epublish
SO  - Balkan J Med Genet. 2017 Jun 30;20(1):35-42. doi: 10.1515/bjmg-2017-0005. 
      eCollection 2017 Jun 30.