PMID- 28925085
OWN - NLM
STAT- MEDLINE
DCOM- 20180802
LR  - 20181202
IS  - 1740-8261 (Electronic)
IS  - 1058-8183 (Linking)
VI  - 59
IP  - 1
DP  - 2018 Jan
TI  - (18) F-FDG-PET/CT as adjunctive diagnostic modalities in canine fever of unknown 
      origin.
PG  - 107-115
LID - 10.1111/vru.12562 [doi]
AB  - Fever of unknown origin (FUO) is a persistent or recurrent fever for which the 
      underlying source has not been identified despite diagnostic investigation. In 
      people, (18) F-fluoro-2-deoxyglucose positron emission tomography ((18) 
      F-FDG-PET) alone or in combination with computed tomography (CT) is often 
      beneficial in detecting the source of fever when other diagnostics have failed. 
      Veterinary reports describing use of these modalities in animals with fever of 
      unknown origin are currently lacking. Aims of this retrospective case series were 
      to describe (18) F-FDG-PET or (18) F-FDG-PET/CT findings in a group of dogs with 
      fever of unknown origin. Dogs presenting to a single center between April 2012 
      and August 2015 were included. A total of four dogs met inclusion criteria and 
      underwent either positron emission tomography (n = 2) or positron emission 
      tomography/CT (n = 2) as a part of their diagnostic investigation. All subjects 
      underwent extensive diagnostic testing prior to (18) F-FDG-PET/CT. Initial 
      diagnostic evaluation failed to identify either a cause of fever or an anatomic 
      location of disease in these four dogs. In each dog, positron emission tomography 
      or positron emission tomography/CT was either able to localize or rule out the 
      presence of focal lesion thereby allowing for directed sampling and/or informed 
      disease treatment. Follow up (18) F-FDG-PET/CT scans performed in two patients 
      showed improvement of observed abnormalities (n = 1) or detected recurrence of 
      disease allowing for repeated treatment before clinical signs recurred (n = 1). 
      Fever resolved after specific treatment in each dog. Findings from the current 
      study supported the use of positron emission tomography or positron emission 
      tomography/CT as adjunctive imaging modalities for diagnosis and gauging response 
      to therapy in dogs with fever of unknown origin.
CI  - (c) 2017 American College of Veterinary Radiology.
FAU - Grobman, Megan
AU  - Grobman M
AUID- ORCID: 0000-0002-7695-5562
AD  - Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, 
      University of Missouri, Columbia, MO, 65211.
FAU - Cohn, Leah
AU  - Cohn L
AD  - Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, 
      University of Missouri, Columbia, MO, 65211.
FAU - Knapp, Stephanie
AU  - Knapp S
AD  - Veterinary Specialty Hospital of the Carolinas, Raleigh, NC, 27616.
FAU - Bryan, Jeffrey N
AU  - Bryan JN
AD  - Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, 
      University of Missouri, Columbia, MO, 65211.
FAU - Reinero, Carol
AU  - Reinero C
AD  - Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, 
      University of Missouri, Columbia, MO, 65211.
LA  - eng
PT  - Journal Article
DEP - 20170918
PL  - England
TA  - Vet Radiol Ultrasound
JT  - Veterinary radiology & ultrasound : the official journal of the American College 
      of Veterinary Radiology and the International Veterinary Radiology Association
JID - 9209635
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Animals
MH  - Dog Diseases/*diagnostic imaging
MH  - Dogs
MH  - Female
MH  - Fever of Unknown Origin/diagnostic imaging/*veterinary
MH  - *Fluorodeoxyglucose F18
MH  - Male
MH  - Missouri
MH  - Positron Emission Tomography Computed Tomography/veterinary
MH  - Positron-Emission Tomography/*veterinary
MH  - *Radiopharmaceuticals
MH  - Retrospective Studies
OTO - NOTNLM
OT  - FUO
OT  - advanced imaging
OT  - glucose
EDAT- 2017/09/20 06:00
MHDA- 2018/08/03 06:00
CRDT- 2017/09/20 06:00
PHST- 2016/09/13 00:00 [received]
PHST- 2017/05/20 00:00 [revised]
PHST- 2017/07/01 00:00 [accepted]
PHST- 2017/09/20 06:00 [pubmed]
PHST- 2018/08/03 06:00 [medline]
PHST- 2017/09/20 06:00 [entrez]
AID - 10.1111/vru.12562 [doi]
PST - ppublish
SO  - Vet Radiol Ultrasound. 2018 Jan;59(1):107-115. doi: 10.1111/vru.12562. Epub 2017 
      Sep 18.