PMID- 28927085
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 14
IP  - 3
DP  - 2017 Sep
TI  - The prognostic implications of growth-related gene product beta in laryngeal 
      squamous cell carcinoma.
PG  - 3337-3342
LID - 10.3892/ol.2017.6604 [doi]
AB  - Growth-related gene product beta (GRObeta) is an angiogenic chemokine that belongs to 
      the CXC chemokine family, and a number of studies have suggested that GRObeta is 
      associated with tumor development and progression. However, a number of studies 
      have investigated the association between GRObeta expression and the clinical 
      attributes of laryngeal squamous cell carcinoma (LSCC). In the present study, 
      one-step quantitative polymerase chain reaction and immunohistochemistry analysis 
      were used to detect GRObeta expression and evaluate the association between its 
      expression and the clinicopathological characteristics of LSCC. The results 
      demonstrated that the GRObeta mRNA and protein expression levels were significantly 
      increased in LSCC compared with the corresponding non-cancerous tissues. GRObeta 
      protein expression in LSCC was associated with tumor-node-metastasis stage, lymph 
      node metastasis and histopathological grade. The Kaplan-Meier method and Cox 
      multi-factor analysis indicated that high GRObeta expression, lymph node metastasis 
      and histopathological grade were significantly associated with poor survival of 
      patients with LSCC. These data indicated that GRObeta may be a novel prognostic 
      biomarker of LSCC.
FAU - Tang, Mingming
AU  - Tang M
AD  - Department of Head and Neck Surgery, Nantong University Affiliated Tumor 
      Hospital, Nantong, Jiangsu 226361, P.R. China.
FAU - Xu, Xinjiang
AU  - Xu X
AD  - Department of Head and Neck Surgery, Nantong University Affiliated Tumor 
      Hospital, Nantong, Jiangsu 226361, P.R. China.
FAU - Chen, Juanjuan
AU  - Chen J
AD  - Department of Medicine, Nantong University Affiliated Tumor Hospital, Nantong, 
      Jiangsu 226361, P.R. China.
FAU - Huang, Jiangfei
AU  - Huang J
AD  - Department of Clinical Pathology, Nantong University Affiliated Hospital, 
      Nantong, Jiangsu 226001, P.R. China.
FAU - Jiang, Bin
AU  - Jiang B
AD  - Department of Head and Neck Surgery, Nantong University Affiliated Tumor 
      Hospital, Nantong, Jiangsu 226361, P.R. China.
FAU - Han, Liang
AU  - Han L
AD  - Department of Head and Neck Surgery, Nantong University Affiliated Tumor 
      Hospital, Nantong, Jiangsu 226361, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170718
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5587977
OTO - NOTNLM
OT  - growth-related gene product beta
OT  - immunohistochemistry
OT  - laryngeal squamous cell carcinoma
OT  - prognosis
OT  - quantitative polymerase chain reaction
EDAT- 2017/09/21 06:00
MHDA- 2017/09/21 06:01
PMCR- 2017/07/18
CRDT- 2017/09/21 06:00
PHST- 2015/09/16 00:00 [received]
PHST- 2017/02/13 00:00 [accepted]
PHST- 2017/09/21 06:00 [entrez]
PHST- 2017/09/21 06:00 [pubmed]
PHST- 2017/09/21 06:01 [medline]
PHST- 2017/07/18 00:00 [pmc-release]
AID - OL-0-0-6604 [pii]
AID - 10.3892/ol.2017.6604 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 Sep;14(3):3337-3342. doi: 10.3892/ol.2017.6604. Epub 2017 Jul 
      18.