PMID- 28927401
OWN - NLM
STAT- MEDLINE
DCOM- 20180514
LR  - 20220317
IS  - 1423-0127 (Electronic)
IS  - 1021-7770 (Print)
IS  - 1021-7770 (Linking)
VI  - 24
IP  - 1
DP  - 2017 Sep 19
TI  - Oxidative toxicity in diabetes and Alzheimer's disease: mechanisms behind ROS/ 
      RNS generation.
PG  - 76
LID - 10.1186/s12929-017-0379-z [doi]
LID - 76
AB  - Reactive oxidative species (ROS) toxicity remains an undisputed cause and link 
      between Alzheimer's disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients 
      with both AD and T2DM have damaged, oxidized DNA, RNA, protein and lipid products 
      that can be used as possible disease progression markers. Although the oxidative 
      stress has been anticipated as a main cause in promoting both AD and T2DM, 
      multiple pathways could be involved in ROS production. The focus of this review 
      is to summarize the mechanisms involved in ROS production and their possible 
      association with AD and T2DM pathogenesis and progression. We have also 
      highlighted the role of current treatments that can be linked with reduced 
      oxidative stress and damage in AD and T2DM.
FAU - Ahmad, Waqar
AU  - Ahmad W
AUID- ORCID: 0000-0003-0474-6558
AD  - School of Biological Sciences, University of Queensland, Brisbane, 4072, 
      Australia. waqarchemist@hotmail.com.
FAU - Ijaz, Bushra
AU  - Ijaz B
AD  - Centre of Excellence in Molecular Biology, University of the Punjab, Thokar Niaz 
      Baig, Lahore, 54000, Pakistan.
FAU - Shabbiri, Khadija
AU  - Shabbiri K
AD  - School of Biological Sciences, University of Queensland, Brisbane, 4072, 
      Australia.
FAU - Ahmed, Fayyaz
AU  - Ahmed F
AD  - Centre of Excellence in Molecular Biology, University of the Punjab, Thokar Niaz 
      Baig, Lahore, 54000, Pakistan.
FAU - Rehman, Sidra
AU  - Rehman S
AD  - COMSATS Institute of Information Technology Abbottabad, Abbottabad, 22010, 
      Pakistan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170919
PL  - England
TA  - J Biomed Sci
JT  - Journal of biomedical science
JID - 9421567
RN  - 0 (Reactive Nitrogen Species)
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Alzheimer Disease/etiology/*physiopathology/prevention & control
MH  - Diabetes Mellitus, Type 2/etiology/*physiopathology/prevention & control
MH  - Humans
MH  - *Oxidative Stress
MH  - Reactive Nitrogen Species/*metabolism
MH  - Reactive Oxygen Species/*metabolism
PMC - PMC5606025
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Anti-diabetic drugs
OT  - Antioxidant treatments
OT  - Oxidative stress
OT  - ROS production
OT  - Type-2 diabetes mellitus
COIS- AUTHORS INFORMATION: Waqar Ahmad is working as Research Officer while Khadija 
      Shabbiri is post-doctoral Research fellow at School of Biological Sciences, 
      University of Queensland, Australia. Bushra Ijaz is Assistant professor at CEMB, 
      University of the Punjab, Lahore, Sidra Rehman is Assistant professor at COMSATS; 
      while Fayyaz Ahmed is PhD a student. ETHICS APPROVAL AND CONSENT TO PARTICIPATE: 
      Not Applicable. CONSENT FOR PUBLICATION: The authors declare that this article is 
      original and never been published before and not submitted to any other journal. 
      COMPETING INTERESTS: The authors have no competing interests. PUBLISHER'S NOTE: 
      Springer Nature remains neutral with regard to jurisdictional claims in published 
      maps and institutional affiliations.
EDAT- 2017/09/21 06:00
MHDA- 2018/05/15 06:00
PMCR- 2017/09/19
CRDT- 2017/09/21 06:00
PHST- 2017/01/05 00:00 [received]
PHST- 2017/09/05 00:00 [accepted]
PHST- 2017/09/21 06:00 [entrez]
PHST- 2017/09/21 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
PHST- 2017/09/19 00:00 [pmc-release]
AID - 10.1186/s12929-017-0379-z [pii]
AID - 379 [pii]
AID - 10.1186/s12929-017-0379-z [doi]
PST - epublish
SO  - J Biomed Sci. 2017 Sep 19;24(1):76. doi: 10.1186/s12929-017-0379-z.