PMID- 28928612
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 0974-2069 (Print)
IS  - 0974-5149 (Electronic)
IS  - 0974-5149 (Linking)
VI  - 10
IP  - 3
DP  - 2017 Sep-Dec
TI  - Human herpesvirus 6-induced inflammatory cardiomyopathy in immunocompetent 
      children.
PG  - 259-268
LID - 10.4103/apc.APC_54_17 [doi]
AB  - Over the last decade, human herpesvirus 6 (HHV-6) has been implicated in the 
      etiology of pediatric myocarditis and subsequent dilated cardiomyopathy (DCM). 
      This review provides an overview of recent literature investigating the 
      pathophysiological relevance of HHV-6 in inflammatory cardiomyopathy. We examined 
      11 cases of previously published pediatric myocarditis and/or DCM associated with 
      HHV-6 and also our experience of detection of virus particles in vascular 
      endothelium of HHV-6 positive endomyocardial biopsy tissue by electron 
      microscopy. The exact role of the presence of HHV-6 and its load remains 
      controversial as the virus is also found in the heart of healthy controls. 
      Therefore, the question remains open whether and how cardiac HHV-6 may be of 
      pathogenetic importance. Quantitative polymerase chain reaction or mRNA testing 
      allows differentiation between low-level latent virus found in asymptomatic 
      myocardium and active HHV-6 infection. Although only a small number of pediatric 
      cases have been reported in literature, HHV-6 should be considered as a causative 
      agent of inflammatory cardiomyopathy, especially in children under three who 
      might be experiencing a primary infection. Future studies are needed to establish 
      a threshold for determining active infection in biopsy samples and the role of 
      coinfections other cardiotropic viruses.
FAU - Reddy, Surabhi
AU  - Reddy S
AD  - HHV-6 Foundation, Santa Barbara, CA, USA.
FAU - Eliassen, Eva
AU  - Eliassen E
AD  - HHV-6 Foundation, Santa Barbara, CA, USA.
FAU - Krueger, Gerhard R
AU  - Krueger GR
AD  - Department of Pathology & Laboratory Medicine, The University of Texas-Houston 
      Medical School, Houston, TX, USA.
FAU - Das, Bibhuti B
AU  - Das BB
AD  - Departement of Pediatrics, UTSW Medical Center, Dallas, TX, USA.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - India
TA  - Ann Pediatr Cardiol
JT  - Annals of pediatric cardiology
JID - 101495459
PMC - PMC5594937
OTO - NOTNLM
OT  - Human herpesvirus 6 cardiomyopathy
OT  - myocarditis in children
OT  - pediatric-dilated cardiomyopathy
COIS- There are no conflicts of interest.
EDAT- 2017/09/21 06:00
MHDA- 2017/09/21 06:01
PMCR- 2017/09/01
CRDT- 2017/09/21 06:00
PHST- 2017/09/21 06:00 [entrez]
PHST- 2017/09/21 06:00 [pubmed]
PHST- 2017/09/21 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - APC-10-259 [pii]
AID - 10.4103/apc.APC_54_17 [doi]
PST - ppublish
SO  - Ann Pediatr Cardiol. 2017 Sep-Dec;10(3):259-268. doi: 10.4103/apc.APC_54_17.