PMID- 28929119
OWN - NLM
STAT- MEDLINE
DCOM- 20180524
LR  - 20231112
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2017
DP  - 2017
TI  - Liver Biomarkers and Lipid Profiles in Mexican and Mexican-American 10- to 
      14-Year-Old Adolescents at Risk for Type 2 Diabetes.
PG  - 4262536
LID - 10.1155/2017/4262536 [doi]
LID - 4262536
AB  - Liver enzymes alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) 
      are markers for type 2 diabetes mellitus (T2DM); alkaline phosphatase is a marker 
      of liver disease. Mexican-American adolescents are disproportionately affected by 
      T2DM, while in Mexico its prevalence is emerging. We assessed liver biomarkers 
      and lipid profiles among Mexican and Mexican-American adolescents 10-14 years old 
      with high/low risk of T2DM through a cross-sectional, descriptive study (Texas n 
      = 144; Mexico n = 149). We included family medical histories, anthropometry, and 
      blood pressure. Obesity was present in one-third of subjects in both sites. ALT 
      (UL) was higher (p < 0.001) in high-risk adolescents (23.5 +/- 19.5 versus 
      17.2 +/- 13.4 for males, 19.7 +/- 11.6 versus 15.1 +/- 5.5 for females), in Toluca and 
      in Texas (26.0 +/- 14.7 versus 20.0 +/- 13.2 for males, 18.2 +/- 13.4 versus 
      14.6 +/- 10.1 for females), as well as GGT (UL) (p < 0.001) (18.7 +/- 11.1 versus 
      12.4 +/- 2.3 for males, 13.6 +/- 5.8 versus 11.5 +/- 3.9 for Mexican females; 
      21.0 +/- 6.8 versus 15.4 +/- 5.5 for males, 14.3 +/- 5.0 versus 13.8 +/- 5.3 for females 
      in Texas). We found no differences by sex or BMI. Total cholesterol and HDL were 
      higher among Mexican-Americans (p < 0.001). In conclusion, multiple risk factors 
      were present in the sample. We found differences by gender and between high and 
      low risk for T2DM adolescents in all liver enzymes in both sites.
FAU - Fernandez-Gaxiola, Ana Cecilia
AU  - Fernandez-Gaxiola AC
AD  - Facultad de Medicina, Universidad Autonoma del Estado de Mexico, Paseo Tollocan 
      Esq. Jesus Carranza. Col. Moderna de la Cruz, 50180 Toluca, MEX, Mexico.
FAU - Valdes-Ramos, Roxana
AU  - Valdes-Ramos R
AUID- ORCID: 0000-0003-0093-886X
AD  - Facultad de Medicina, Universidad Autonoma del Estado de Mexico, Paseo Tollocan 
      Esq. Jesus Carranza. Col. Moderna de la Cruz, 50180 Toluca, MEX, Mexico.
FAU - Fulda, Kimberly G
AU  - Fulda KG
AD  - Department of Family Medicine, Texas Prevention Institute, University of North 
      Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA.
FAU - Lopez, Ana Laura Guadarrama
AU  - Lopez ALG
AUID- ORCID: 0000-0002-0294-2515
AD  - Facultad de Medicina, Universidad Autonoma del Estado de Mexico, Paseo Tollocan 
      Esq. Jesus Carranza. Col. Moderna de la Cruz, 50180 Toluca, MEX, Mexico.
FAU - Martinez-Carrillo, Beatriz E
AU  - Martinez-Carrillo BE
AD  - Facultad de Medicina, Universidad Autonoma del Estado de Mexico, Paseo Tollocan 
      Esq. Jesus Carranza. Col. Moderna de la Cruz, 50180 Toluca, MEX, Mexico.
FAU - Franks, Susan F
AU  - Franks SF
AD  - Department of Family Medicine, Texas Prevention Institute, University of North 
      Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA.
FAU - Fernando, Shane
AU  - Fernando S
AD  - Department of Pediatrics, Texas Prevention Institute, University of North Texas 
      Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA.
LA  - eng
PT  - Journal Article
DEP - 20170726
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 0 (Lipids)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 2.6.1.2 (Alanine Transaminase)
SB  - IM
MH  - Adolescent
MH  - Alanine Transaminase/*blood
MH  - Biomarkers/blood
MH  - Child
MH  - Diabetes Mellitus, Type 2/blood/*diagnosis
MH  - Female
MH  - Humans
MH  - Lipids/*blood
MH  - Liver/*enzymology
MH  - Male
MH  - Mexican Americans
MH  - Mexico
MH  - Risk Factors
MH  - United States
MH  - gamma-Glutamyltransferase/*blood
PMC - PMC5592011
EDAT- 2017/09/21 06:00
MHDA- 2018/05/25 06:00
PMCR- 2017/07/26
CRDT- 2017/09/21 06:00
PHST- 2017/03/21 00:00 [received]
PHST- 2017/07/03 00:00 [accepted]
PHST- 2017/09/21 06:00 [entrez]
PHST- 2017/09/21 06:00 [pubmed]
PHST- 2018/05/25 06:00 [medline]
PHST- 2017/07/26 00:00 [pmc-release]
AID - 10.1155/2017/4262536 [doi]
PST - ppublish
SO  - J Diabetes Res. 2017;2017:4262536. doi: 10.1155/2017/4262536. Epub 2017 Jul 26.