PMID- 28929810
OWN - NLM
STAT- MEDLINE
DCOM- 20171113
LR  - 20171113
IS  - 1546-3141 (Electronic)
IS  - 0361-803X (Linking)
VI  - 209
IP  - 5
DP  - 2017 Nov
TI  - Dynamic Contrast-Enhanced Perfusion Area-Detector CT: Preliminary Comparison of 
      Diagnostic Performance for N Stage Assessment With FDG PET/CT in Non-Small Cell 
      Lung Cancer.
PG  - W253-W262
LID - 10.2214/AJR.17.17959 [doi]
AB  - OBJECTIVE: The objective of our study was to directly compare the capability of 
      dynamic first-pass contrast-enhanced (CE) perfusion area-detector CT (ADCT) and 
      FDG PET/CT for differentiation of metastatic from nonmetastatic lymph nodes and 
      assessment of N stage in patients with non-small cell lung carcinoma (NSCLC). 
      SUBJECTS AND METHODS: Seventy-seven consecutive patients, 45 men (mean age +/- SD, 
      70.4 +/- 5.9 years) and 32 women (71.2 +/- 7.7 years), underwent dynamic first-pass 
      CE-perfusion ADCT at two or three different positions for covering the entire 
      thorax, FDG PET/CT, surgical treatment, and pathologic examination. From all ADCT 
      data for each of the subjects, a whole-chest perfusion map was computationally 
      generated using the dual- and single-input maximum slope and Patlak plot methods. 
      For quantitative N stage assessment, perfusion parameters and the maximum 
      standardized uptake value (SUV(max)) for each lymph node were determined by 
      measuring the relevant ROI. ROC curve analyses were performed for comparing the 
      diagnostic capability of each of the methods on a per-node basis. N stages 
      evaluated by each of the indexes were then statistically compared with the final 
      pathologic diagnosis by means of chi-square and kappa statistics. RESULTS: The 
      area under the ROC curve (A(z)) values of systemic arterial perfusion (A(z) = 
      0.89), permeability surface (A(z) = 0.78), and SUV(max) (A(z) = 0.85) were 
      significantly larger than the A(z) values of total perfusion (A(z) = 0.70, p < 
      0.05) and distribution volume (A(z) = 0.55, p < 0.05). For each of the threshold 
      values, agreement for systemic arterial perfusion calculated using the dual-input 
      maximum slope model was substantial (kappa = 0.70, p < 0.0001), and agreement for 
      SUV(max) was moderate (kappa = 0.60, p < 0.0001). CONCLUSION: Dynamic first-pass 
      CE-perfusion ADCT is as useful as FDG PET/CT for the differentiation of 
      metastatic from nonmetastatic lymph nodes and assessment of N stage in patients 
      with NSCLC.
FAU - Ohno, Yoshiharu
AU  - Ohno Y
AD  - 1 Department of Radiology, Division of Functional and Diagnostic Imaging 
      Research, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, 
      Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
AD  - 2 Advanced Biomedical Imaging Research Center, Kobe University Graduate School of 
      Medicine, Kobe, Hyogo, Japan.
FAU - Fujisawa, Yasuko
AU  - Fujisawa Y
AD  - 3 Toshiba Medical Systems Corporation, Otawara, Tochigi, Japan.
FAU - Sugihara, Naoki
AU  - Sugihara N
AD  - 3 Toshiba Medical Systems Corporation, Otawara, Tochigi, Japan.
FAU - Kishida, Yuji
AU  - Kishida Y
AD  - 4 Department of Radiology, Kobe University Graduate School of Medicine, Kobe, 
      Hyogo, Japan.
FAU - Seki, Shinichiro
AU  - Seki S
AD  - 1 Department of Radiology, Division of Functional and Diagnostic Imaging 
      Research, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, 
      Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
AD  - 2 Advanced Biomedical Imaging Research Center, Kobe University Graduate School of 
      Medicine, Kobe, Hyogo, Japan.
FAU - Koyama, Hisanobu
AU  - Koyama H
AD  - 4 Department of Radiology, Kobe University Graduate School of Medicine, Kobe, 
      Hyogo, Japan.
AD  - 5 Department of Radiology, Osaka Police Hospital, Osaka, Japan.
FAU - Yoshikawa, Takeshi
AU  - Yoshikawa T
AD  - 1 Department of Radiology, Division of Functional and Diagnostic Imaging 
      Research, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, 
      Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
AD  - 2 Advanced Biomedical Imaging Research Center, Kobe University Graduate School of 
      Medicine, Kobe, Hyogo, Japan.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170920
PL  - United States
TA  - AJR Am J Roentgenol
JT  - AJR. American journal of roentgenology
JID - 7708173
RN  - 0 (Radiopharmaceuticals)
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/*diagnostic imaging/secondary
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Humans
MH  - Lung Neoplasms/*diagnostic imaging/pathology
MH  - Male
MH  - Middle Aged
MH  - Models, Theoretical
MH  - Neoplasm Staging
MH  - Observer Variation
MH  - *Positron Emission Tomography Computed Tomography
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - ROC Curve
MH  - Radiopharmaceuticals
OTO - NOTNLM
OT  - CT
OT  - PET/CT
OT  - lymph node metastasis
OT  - non-small cell lung cancer
OT  - perfusion
OT  - perfusion CT
EDAT- 2017/09/21 06:00
MHDA- 2017/11/14 06:00
CRDT- 2017/09/21 06:00
PHST- 2017/09/21 06:00 [pubmed]
PHST- 2017/11/14 06:00 [medline]
PHST- 2017/09/21 06:00 [entrez]
AID - 10.2214/AJR.17.17959 [doi]
PST - ppublish
SO  - AJR Am J Roentgenol. 2017 Nov;209(5):W253-W262. doi: 10.2214/AJR.17.17959. Epub 
      2017 Sep 20.