PMID- 28930482
OWN - NLM
STAT- MEDLINE
DCOM- 20180727
LR  - 20180801
IS  - 1744-8352 (Electronic)
IS  - 1473-7159 (Linking)
VI  - 17
IP  - 11
DP  - 2017 Nov
TI  - Diagnostic and prognostic cytogenetics of chronic myeloid leukaemia: an update.
PG  - 1001-1008
LID - 10.1080/14737159.2017.1383156 [doi]
AB  - Despite the advent of molecular assessment, banding cytogenetics and fluorescence 
      in situ hybridization (FISH) still have a significant role in diagnostic and 
      prognostic approaches to chronic myeloid leukaemia (CML). Area covered: At 
      diagnosis and during treatment with tyrosine kinase inhibitors (TKIs), 
      cytogenetics is used to detect the Philadelphia chromosome, with its typical 
      translocation t(9;22)(q34;q11.2), and any additional or other chromosomal 
      aberrations (ACAs and OCAs) that may arise in 5-10% of cases, the latter 
      associated to transformation of the disease in blast phases. In this review, the 
      potential role of banding cytogenetics and FISH is discussed through a review of 
      published papers on the prognostic impact of these tools in CML treatment and 
      monitoring. Expert commentary: Cytogenetic techniques, including banding 
      cytogenetics and FISH, continue to maintain a crucial role in CML monitoring. At 
      diagnosis and after 3 months of therapy, banding cytogenetics will continue to be 
      an essential test to perform, but it will become redundant after the achievement 
      of a major molecular response (MMR) assessed with molecular techniques. FISH 
      analysis maintains its usefulness in monitoring the response to TKIs only in 
      special situations.
FAU - Molica, Matteo
AU  - Molica M
AD  - a Hematology, Department of Cellular Biotechnologies and Hematology , Sapienza 
      University , Rome , Italy.
FAU - Massaro, Fulvio
AU  - Massaro F
AD  - a Hematology, Department of Cellular Biotechnologies and Hematology , Sapienza 
      University , Rome , Italy.
FAU - Breccia, Massimo
AU  - Breccia M
AD  - a Hematology, Department of Cellular Biotechnologies and Hematology , Sapienza 
      University , Rome , Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170926
PL  - England
TA  - Expert Rev Mol Diagn
JT  - Expert review of molecular diagnostics
JID - 101120777
SB  - IM
MH  - Chromosome Aberrations
MH  - Chromosome Banding
MH  - Cytogenetic Analysis
MH  - Genetic Testing
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*diagnosis/genetics/*mortality
MH  - Philadelphia Chromosome
MH  - Prognosis
OTO - NOTNLM
OT  - Banding cytogenetics
OT  - additional chromosome abnormalities (ACAs)
OT  - chronic myeloid leukaemia (CML)
OT  - fluorescence in situ hybridization (FISH)
OT  - other chromosome abnormalities (OCAs)
EDAT- 2017/09/21 06:00
MHDA- 2018/07/28 06:00
CRDT- 2017/09/21 06:00
PHST- 2017/09/21 06:00 [pubmed]
PHST- 2018/07/28 06:00 [medline]
PHST- 2017/09/21 06:00 [entrez]
AID - 10.1080/14737159.2017.1383156 [doi]
PST - ppublish
SO  - Expert Rev Mol Diagn. 2017 Nov;17(11):1001-1008. doi: 
      10.1080/14737159.2017.1383156. Epub 2017 Sep 26.