PMID- 28931401
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 19
IP  - 1
DP  - 2017 Sep 21
TI  - A novel multiparametric imaging approach to acute myocarditis using T2-mapping 
      and CMR feature tracking.
PG  - 71
LID - 10.1186/s12968-017-0387-x [doi]
LID - 71
AB  - BACKGROUND: The aim of this study was to evaluate the diagnostic potential of a 
      novel cardiovascular magnetic resonance (CMR) based multiparametric imaging 
      approach in suspected myocarditis and to compare it to traditional Lake Louise 
      criteria (LLC). METHODS: CMR data from 67 patients with suspected acute 
      myocarditis were retrospectively analyzed. Seventeen age- and gender-matched 
      healthy subjects served as control. T2-mapping data were acquired using a 
      Gradient-Spin-Echo T2-mapping sequence in short-axis orientation. T2-maps were 
      segmented according to the 16-segments AHA-model and segmental T2 values and 
      pixel-standard deviation (SD) were recorded. Afterwards, the parameters maxT2 
      (the highest segmental T2 value) and madSD (the mean absolute deviation (MAD) of 
      the pixel-SDs) were calculated for each subject. Cine sequences in three long 
      axes and a stack of short-axis views covering the left and right ventricle were 
      analyzed using a dedicated feature tracking algorithm. RESULTS: A multiparametric 
      imaging model containing madSD and LV global circumferential strain (GCS(LV)) 
      resulted in the highest diagnostic performance in receiver operating curve 
      analyses (area under the curve [AUC] 0.84) when compared to any model containing 
      a single imaging parameter or to LLC (AUC 0.79). Adding late gadolinium 
      enhancement (LGE) to the model resulted in a further increased diagnostic 
      performance (AUC 0.93) and yielded the highest diagnostic sensitivity of 97% and 
      specificity of 77%. CONCLUSIONS: A multiparametric CMR imaging model including 
      the novel T2-mapping derived parameter madSD, the feature tracking derived strain 
      parameter GCS(LV) and LGE yields superior diagnostic sensitivity in suspected 
      acute myocarditis when compared to any imaging parameter alone and to LLC.
FAU - Baessler, Bettina
AU  - Baessler B
AUID- ORCID: 0000-0002-3244-3864
AD  - Department of Radiology, University Hospital of Cologne, Kerpener Str. 62, 
      D-50937, Cologne, Germany. bettina.baessler@uk-koeln.de.
FAU - Treutlein, Melanie
AU  - Treutlein M
AD  - Department of Radiology, University Hospital of Cologne, Kerpener Str. 62, 
      D-50937, Cologne, Germany.
FAU - Schaarschmidt, Frank
AU  - Schaarschmidt F
AD  - Institute of Biostatistics, Faculty of Natural Sciences, Leibniz Universitat 
      Hannover, Hannover, Germany.
FAU - Stehning, Christian
AU  - Stehning C
AD  - Philips Research, Hamburg, Germany.
FAU - Schnackenburg, Bernhard
AU  - Schnackenburg B
AD  - Philips, Healthcare Germany, Hamburg, Germany.
FAU - Michels, Guido
AU  - Michels G
AD  - Department III of Internal Medicine, Heart Centre, University Hospital of 
      Cologne, Cologne, Germany.
FAU - Maintz, David
AU  - Maintz D
AD  - Department of Radiology, University Hospital of Cologne, Kerpener Str. 62, 
      D-50937, Cologne, Germany.
FAU - Bunck, Alexander C
AU  - Bunck AC
AD  - Department of Radiology, University Hospital of Cologne, Kerpener Str. 62, 
      D-50937, Cologne, Germany.
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
DEP - 20170921
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
SB  - IM
MH  - Adult
MH  - Algorithms
MH  - Area Under Curve
MH  - Biomechanical Phenomena
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Myocarditis/*diagnostic imaging/physiopathology
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Ventricular Function, Left
MH  - Ventricular Function, Right
MH  - Young Adult
PMC - PMC5607501
OTO - NOTNLM
OT  - Cardiac magnetic resonance imaging
OT  - Feature tracking
OT  - Myocardial inflammation
OT  - Myocarditis
OT  - Strain
OT  - Strain rate
OT  - T2-mapping
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Ethical approval was obtained by the 
      local Institutional Review Board of the University Hospital of Cologne for the 
      retrospective patient selection (reference number 14-174) as well as for the 
      volunteer study (reference number 13-324). For each volunteer written informed 
      consent was obtained prior to the study. CONSENT FOR PUBLICATION: Not applicable. 
      COMPETING INTERESTS: Dr. Stehning and Dr. Schnackenburg are employees of Philips 
      Research and Philips Healthcare, respectively. All other authors declare that 
      they have no competing interests. PUBLISHER'S NOTE: Springer Nature remains 
      neutral with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2017/09/22 06:00
MHDA- 2018/06/05 06:00
PMCR- 2017/09/21
CRDT- 2017/09/22 06:00
PHST- 2016/12/07 00:00 [received]
PHST- 2017/09/12 00:00 [accepted]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2017/09/21 00:00 [pmc-release]
AID - S1097-6647(23)01105-5 [pii]
AID - 387 [pii]
AID - 10.1186/s12968-017-0387-x [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2017 Sep 21;19(1):71. doi: 10.1186/s12968-017-0387-x.