PMID- 28931765
OWN - NLM
STAT- MEDLINE
DCOM- 20190826
LR  - 20191008
IS  - 2379-3708 (Electronic)
IS  - 2379-3708 (Linking)
VI  - 2
IP  - 18
DP  - 2017 Sep 21
TI  - A type of human skin dendritic cell marked by CD5 is associated with the 
      development of inflammatory skin disease.
LID - 96101 [pii]
LID - 10.1172/jci.insight.96101 [doi]
LID - e96101
AB  - Dendritic cells (DCs) are important in regulating immunity and tolerance and 
      consist of functionally distinct subsets that differentially regulate T 
      lymphocyte function. The underlying basis for this subset specificity is lacking, 
      particularly in humans, where the classification of tissue DCs is currently 
      incomplete. Examination of healthy human epidermal Langerhans cells and dermal 
      skin cells revealed a tissue CD5-expressing DC subtype. The CD5+ DCs were potent 
      inducers of cytotoxic T cells and Th22 cells. The products of these T cells, 
      IL-22 and IFN-gamma, play a key role in the pathogenesis of psoriasis. Remarkably, 
      CD5+ DCs were significantly enriched in lesional psoriatic skin compared with 
      distal tissues, suggesting their involvement in the disease. We show that CD5+ 
      DCs can be differentiated from hematopoietic progenitor cells independently of 
      the CD5- DCs. A progenitor population found in human cord blood and in the dermal 
      skin layer, marked as CD34-CD123+CD117dimCD45RA+, was an immediate precursor of 
      these CD11c+CD1c+CD5+ DCs. Overall, our discovery of the CD5-expressing DC 
      subtype suggests that strategies to regulate their composition or function in the 
      skin will represent an innovative approach for the treatment of immune-mediated 
      disorders in and beyond the skin.
FAU - Korenfeld, Daniel
AU  - Korenfeld D
AD  - Department of Pathology and Immunology, Division of Immunobiology.
FAU - Gorvel, Laurent
AU  - Gorvel L
AD  - Department of Pathology and Immunology, Division of Immunobiology.
FAU - Munk, Adiel
AU  - Munk A
AD  - Department of Pathology and Immunology, Division of Immunobiology.
FAU - Man, Joshua
AU  - Man J
AD  - Department of Pathology and Immunology, Division of Immunobiology.
FAU - Schaffer, Andras
AU  - Schaffer A
AD  - Department of Pathology and Immunology, Dermatopathology Center.
FAU - Tung, Thomas
AU  - Tung T
AD  - Department of Surgery, Division of Plastic and Reconstructive Surgery, and.
FAU - Mann, Caroline
AU  - Mann C
AD  - Department of Medicine, Division of Dermatology, Washington University School of 
      Medicine in St. Louis, St. Louis, Missouri, USA.
FAU - Klechevsky, Eynav
AU  - Klechevsky E
AD  - Department of Pathology and Immunology, Division of Immunobiology.
LA  - eng
GR  - P30 CA091842/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170921
PL  - United States
TA  - JCI Insight
JT  - JCI insight
JID - 101676073
RN  - 0 (Antigens, CD)
RN  - 0 (CD5 Antigens)
MH  - Antigens, CD/immunology
MH  - CD5 Antigens/*immunology
MH  - Cell Differentiation
MH  - Dendritic Cells/*cytology/immunology
MH  - Humans
MH  - Immunophenotyping
MH  - Psoriasis/*immunology
MH  - Skin/*cytology/immunology
PMC - PMC5621884
OTO - NOTNLM
OT  - Dendritic cells
OT  - Immunology
OT  - Inflammation
COIS- Conflict of interest: The authors have declared that no conflict of interest 
      exists.
EDAT- 2017/09/22 06:00
MHDA- 2019/08/27 06:00
PMCR- 2017/09/21
CRDT- 2017/09/22 06:00
PHST- 2017/07/05 00:00 [received]
PHST- 2017/08/10 00:00 [accepted]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2019/08/27 06:00 [medline]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/21 00:00 [pmc-release]
AID - 96101 [pii]
AID - 10.1172/jci.insight.96101 [doi]
PST - epublish
SO  - JCI Insight. 2017 Sep 21;2(18):e96101. doi: 10.1172/jci.insight.96101. 
      eCollection 2017 Sep 21.