PMID- 28931777
OWN - NLM
STAT- MEDLINE
DCOM- 20180427
LR  - 20220321
IS  - 1347-7439 (Electronic)
IS  - 0916-7250 (Print)
IS  - 0916-7250 (Linking)
VI  - 79
IP  - 11
DP  - 2017 Nov 10
TI  - Antidepressant-like effect of milk-derived lactoferrin in the repeated 
      forced-swim stress mouse model.
PG  - 1803-1806
LID - 10.1292/jvms.17-0200 [doi]
AB  - We investigated the antidepressant-like effect of lactoferrin (Lf) in a repeated 
      forced-swim test (FST) stress mouse model. FST was performed on days 1, 2, 7 and 
      14. Bovine Lf (bLf) or bovine serum albumin (BSA) was supplemented at 1% to the 
      commercial diet after the first FST throughout the experimental period. The 
      FST-control and FST+BSA group showed a marked increase in immobility time on day 
      2, which remained increased up to the 14th day, while the FST+bLf group showed a 
      significant lower immobility time. Brain-derived neurotrophic factor (BDNF) 
      content in the hippocampus significantly decreased in all of FST treated groups. 
      These results suggest that bLf may improve the depressive-like symptoms induced 
      by repeated FST.
FAU - Takeuchi, Takashi
AU  - Takeuchi T
AD  - Course of Veterinary Laboratory Medicine, Department of Veterinary Medicine, 
      Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
FAU - Matsunaga, Kana
AU  - Matsunaga K
AD  - Course of Veterinary Laboratory Medicine, Department of Veterinary Medicine, 
      Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
FAU - Sugiyama, Akihiko
AU  - Sugiyama A
AD  - Course of Veterinary Laboratory Medicine, Department of Veterinary Medicine, 
      Faculty of Agriculture, Tottori University, Tottori 680-8553, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170921
PL  - Japan
TA  - J Vet Med Sci
JT  - The Journal of veterinary medical science
JID - 9105360
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 3.4.21.- (Lactoferrin)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Depression/*drug therapy/etiology
MH  - Disease Models, Animal
MH  - Hippocampus/chemistry
MH  - Lactoferrin/*pharmacology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Stress, Psychological
MH  - Swimming
PMC - PMC5709556
OTO - NOTNLM
OT  - BDNF
OT  - antidepressant
OT  - corticosterone
OT  - lactoferrin
OT  - repeated forced-swim test
EDAT- 2017/09/22 06:00
MHDA- 2018/04/28 06:00
PMCR- 2017/11/01
CRDT- 2017/09/22 06:00
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2018/04/28 06:00 [medline]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/11/01 00:00 [pmc-release]
AID - 17-0200 [pii]
AID - 10.1292/jvms.17-0200 [doi]
PST - ppublish
SO  - J Vet Med Sci. 2017 Nov 10;79(11):1803-1806. doi: 10.1292/jvms.17-0200. Epub 2017 
      Sep 21.