PMID- 28931918
OWN - NLM
STAT- MEDLINE
DCOM- 20190701
LR  - 20220318
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Sep 20
TI  - Association of HLA-B and HLA-DRB1 polymorphisms with antithyroid drug-induced 
      agranulocytosis in a Han population from northern China.
PG  - 11950
LID - 10.1038/s41598-017-12350-2 [doi]
LID - 11950
AB  - Antithyroid drug (ATD)-induced agranulocytosis is associated with human leukocyte 
      antigen (HLA) and nearby genes in Southeast Asian and European populations. The 
      susceptibility of the Han population from northern China to ATD-induced 
      agranulocytosis has not been reported. We evaluated the associations of genetic 
      variants at the HLA-B and HLA-DRB1 loci and 32 candidate single nucleotide 
      polymorphisms (SNPs) with agranulocytosis in 29 patients with ATD-induced 
      agranulocytosis and in 140 patients with Graves' disease (GD) as controls. All 
      subjects were of Han descent from northern China. HLA-B*27:05 
      (P = 1.10 x 10(-4)), HLA-B*38:02 (P = 2.41 x 10(-4)) and HLA-DRB1*08:03 
      (P = 1.57 x 10(-3)) were susceptibility HLA variants for ATD-induced 
      agranulocytosis. All subjects carrying the HLA-B*27:05 allele had 
      agranulocytosis. The odds ratios (ORs) comparing allele carriers to non-carriers 
      were 66.24 (95% confidence interval (CI): 3.54-1239.66) for HLA-B*27:05, 7.525 
      (95% CI: 2.294-24.68) for HLA-B*38:02 and 4.316 (95% CI: 1.56-11.93) for 
      HLA-DRB1*08:03. Two SNPs, rs2596487 (OR = 4.196, 95% CI = 2.086-8.441, 
      P = 2.08 x 10(-5)) and rs2228391 (OR = 3.621, 95% CI = 1.596-8.217, 
      P = 1.2 x 10(-3)), were independently associated with ATD-induced 
      agranulocytosis. Subjects carrying the 'A' allele of rs1811197 or HLA-B*38:02 
      showed lower minimum granulocyte counts than non-carriers (P = 4.74 x 10(-4) and 
      P = 7.39 x 10(-4), respectively). Our findings support the association between 
      genetic variations of HLA-B and HLA-DRB1 with ATD-induced agranulocytosis in a 
      Han population from northern China.
FAU - He, Yayi
AU  - He Y
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi Province, The People's Republic of China.
FAU - Zheng, Jie
AU  - Zheng J
AD  - Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi Province, The People's Republic of China.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - College of Medicine & Forensic, Health Science Center, Xi'an Jiaotong University, 
      Xi'an, Shaanxi Province, The People's Republic of China.
FAU - Hou, Peng
AU  - Hou P
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi Province, The People's Republic of China.
FAU - Zhu, Feng
AU  - Zhu F
AD  - Center for Translational Medicine, The First Affiliated Hospital of Xi'an 
      Jiaotong University, Xi'an, Shaanxi Province, The People's Republic of China.
FAU - Yang, Jian
AU  - Yang J
AD  - Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi Province, The People's Republic of China.
FAU - Li, Wenhao
AU  - Li W
AD  - School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, 
      Shaanxi Province, The People's Republic of China.
FAU - Chen, Pu
AU  - Chen P
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi Province, The People's Republic of China.
FAU - Liu, Shu
AU  - Liu S
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi Province, The People's Republic of China.
FAU - Zhang, Bao
AU  - Zhang B
AD  - College of Medicine & Forensic, Health Science Center, Xi'an Jiaotong University, 
      Xi'an, Shaanxi Province, The People's Republic of China. 
      zhangbao_814@mail.xjtu.edu.cn.
FAU - Shi, Bingyin
AU  - Shi B
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi Province, The People's Republic of China. 
      shibingy@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170920
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Antithyroid Agents)
RN  - 0 (HLA-B protein, human)
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Agranulocytosis/*chemically induced/*genetics
MH  - Antithyroid Agents/administration & dosage/*adverse effects
MH  - China
MH  - Ethnicity
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Young Adult
PMC - PMC5607267
COIS- The authors declare that they have no competing interests.
EDAT- 2017/09/22 06:00
MHDA- 2019/07/02 06:00
PMCR- 2017/09/20
CRDT- 2017/09/22 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/09/07 00:00 [accepted]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2019/07/02 06:00 [medline]
PHST- 2017/09/20 00:00 [pmc-release]
AID - 10.1038/s41598-017-12350-2 [pii]
AID - 12350 [pii]
AID - 10.1038/s41598-017-12350-2 [doi]
PST - epublish
SO  - Sci Rep. 2017 Sep 20;7(1):11950. doi: 10.1038/s41598-017-12350-2.