PMID- 28932240 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220317 IS - 1687-8337 (Print) IS - 1687-8345 (Electronic) IS - 1687-8337 (Linking) VI - 2017 DP - 2017 TI - Perspectives on Peripheral Neuropathy as a Consequence of Metformin-Induced Vitamin B12 Deficiency in T2DM. PG - 2452853 LID - 10.1155/2017/2452853 [doi] LID - 2452853 AB - Peripheral neuropathy (PN) is a primary complication of type 2 diabetes mellitus (T2DM) and a direct manifestation of vitamin B12 deficiency. Examining the effects of metformin use on PN status became imperative following clinical studies that showed the vitamin B12-lowering effect of the medication. The complexity of the topic and the inconsistency of the results warrant consideration of topic-specific perspectives for better understanding of the available evidence and more appropriate design of future studies. FAU - Ahmed, Marwan A AU - Ahmed MA AUID- ORCID: 0000-0002-3909-7220 AD - Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. FAU - Muntingh, George L AU - Muntingh GL AD - Department of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. FAU - Rheeder, Paul AU - Rheeder P AD - Department of Internal Medicine, Steve Biko Academic Hospital, University of Pretoria, Pretoria, South Africa. LA - eng PT - Journal Article PT - Review DEP - 20170827 PL - Egypt TA - Int J Endocrinol JT - International journal of endocrinology JID - 101516376 PMC - PMC5591993 EDAT- 2017/09/22 06:00 MHDA- 2017/09/22 06:01 PMCR- 2017/08/27 CRDT- 2017/09/22 06:00 PHST- 2017/05/08 00:00 [received] PHST- 2017/07/31 00:00 [accepted] PHST- 2017/09/22 06:00 [entrez] PHST- 2017/09/22 06:00 [pubmed] PHST- 2017/09/22 06:01 [medline] PHST- 2017/08/27 00:00 [pmc-release] AID - 10.1155/2017/2452853 [doi] PST - ppublish SO - Int J Endocrinol. 2017;2017:2452853. doi: 10.1155/2017/2452853. Epub 2017 Aug 27.