PMID- 28932290
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1758-5996 (Print)
IS  - 1758-5996 (Electronic)
IS  - 1758-5996 (Linking)
VI  - 9
DP  - 2017
TI  - Moderate- to high-intensity statins for secondary prevention in patients with 
      type 2 diabetes mellitus on dialysis after acute myocardial infarction.
PG  - 71
LID - 10.1186/s13098-017-0272-7 [doi]
LID - 71
AB  - BACKGROUND: Evidences support the benefits of moderate- to high-intensity statins 
      for patients with acute myocardial infarction (AMI) except for those with type 2 
      diabetes mellitus (T2DM) on dialysis after AMI. This study was aimed to 
      investigate the safety and efficacy of secondary prevention of cardiovascular 
      diseases using moderate- to high-intensity statins in T2DM patients on dialysis 
      after AMI. METHODS: A simulated prospective cohort study was conducted between 
      January 1st, 2001 and December 31st, 2013 utilizing data from the Taiwan National 
      Health Insurance Research Database. A total of 882 patients with T2DM on dialysis 
      after AMI were selected as the study cohort. Cardiovascular efficacy and safety 
      of moderate- to high-intensity statins were evaluated by comparing outcomes of 
      441 subjects receiving statins after AMI to 441 matched subjects not receiving 
      statins after AMI. The primary composite outcome included cardiovascular death, 
      non-fatal myocardial infarction and non-fatal ischemic stroke. RESULTS: The 
      Kaplan-Meier event rate for the primary composite outcomes at 8 years was 30.2% 
      (133 patients) in the statin group compared with 25.2% (111 patients) in the 
      non-statin group (hazard ratio [HR], .98; 95% confidence interval [CI] .76-1.27). 
      Significantly lower risks of non-fatal ischemic stroke (HR, .58; 95% CI .35-.98) 
      and all-cause mortality (HR, .70; 95% CI .59-.84) were found in the statin group. 
      CONCLUSIONS: In T2DM patients on dialysis after AMI, the use of moderate- to 
      high-intensity statins has neutral effects on composite cardiovascular events but 
      may reduce risks of non-fatal ischemic stroke and all-cause mortality.
FAU - Li, Yan-Rong
AU  - Li YR
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang 
      Gung Memorial Hospital, Linkou, Taiwan.
FAU - Tsai, Sung-Sheng
AU  - Tsai SS
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang 
      Gung Memorial Hospital, Linkou, Taiwan.
FAU - Lin, Yu-Sheng
AU  - Lin YS
AD  - Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, Taiwan. ISNI: 0000 
      0004 1756 1410. GRID: grid.454212.4
FAU - Chung, Chang-Min
AU  - Chung CM
AD  - Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, Taiwan. ISNI: 0000 
      0004 1756 1410. GRID: grid.454212.4
AD  - School of Traditional Chinese Medicine, College of Medicine, Chang Gung 
      University, Taoyuan, Taiwan. GRID: grid.145695.a
FAU - Chen, Szu-Tah
AU  - Chen ST
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang 
      Gung Memorial Hospital, Linkou, Taiwan.
FAU - Sun, Jui-Hung
AU  - Sun JH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang 
      Gung Memorial Hospital, Linkou, Taiwan.
FAU - Liou, Miaw-Jene
AU  - Liou MJ
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang 
      Gung Memorial Hospital, Linkou, Taiwan.
FAU - Chen, Tien-Hsing
AU  - Chen TH
AD  - Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, No. 222, Maijin Road, Keelung, Taiwan. ISNI: 0000 0004 0639 2551. GRID: 
      grid.454209.e
AD  - Chang Gung University College of Medicine, Taoyuan, Taiwan. GRID: grid.145695.a
LA  - eng
PT  - Journal Article
DEP - 20170919
PL  - England
TA  - Diabetol Metab Syndr
JT  - Diabetology & metabolic syndrome
JID - 101488958
PMC - PMC5605978
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Dialysis
OT  - Mortality
OT  - Secondary prevention
OT  - Statins
OT  - Type 2 diabetes mellitus
EDAT- 2017/09/22 06:00
MHDA- 2017/09/22 06:01
PMCR- 2017/09/19
CRDT- 2017/09/22 06:00
PHST- 2017/07/20 00:00 [received]
PHST- 2017/09/14 00:00 [accepted]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/22 06:01 [medline]
PHST- 2017/09/19 00:00 [pmc-release]
AID - 272 [pii]
AID - 10.1186/s13098-017-0272-7 [doi]
PST - epublish
SO  - Diabetol Metab Syndr. 2017 Sep 19;9:71. doi: 10.1186/s13098-017-0272-7. 
      eCollection 2017.