PMID- 28932387
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2045-7022 (Print)
IS  - 2045-7022 (Electronic)
IS  - 2045-7022 (Linking)
VI  - 7
DP  - 2017
TI  - Peak nasal inspiratory flow as outcome for provocation studies in allergen 
      exposure chambers: a GA(2)LEN study.
PG  - 33
LID - 10.1186/s13601-017-0169-4 [doi]
LID - 33
AB  - BACKGROUND: The GA(2)LEN chamber has been developed as a novel mobile allergen 
      exposure chamber (AEC) allowing standardized multicenter trials in allergy. 
      Hitherto, subjective nasal symptom scores have been the most often used outcome 
      parameter, but in standardized modern trials objective parameters are preferred. 
      Despite its practicability, the objective parameter peak nasal inspiratory flow 
      (PNIF) has been rarely used for allergy trials in the setting of allergen 
      exposure chambers. This study aims to evaluate PNIF as an outcome parameter for 
      provocation studies in AECs. METHODS: In a randomized controlled blinded setting 
      subjects suffering from allergic rhinitis were exposed to grass pollen, birch 
      pollen, house dust mite and/or placebo in the GA(2)LEN chamber. Different 
      allergen concentrations were used to evaluate symptom severities. Patients had to 
      perform PNIF before and every 30 min during a challenge using a portable PNIF 
      meter. RESULTS: 86 subjects participated in 203 challenges, altogether. House 
      dust mite provocations caused the greatest reduction in PNIF values, followed by 
      grass pollen and birch pollen. Provocations with every allergen or pollen 
      concentration led to a significant decrease (p < 0.05) in PNIF compared to 
      baseline. Furthermore, positive correlations were obtained between PNIF and peak 
      expiratory flow, height and weight, and inverse correlations between PNIF and 
      total nasal symptom score, nasal congestion score and visual analog scale of 
      overall subjective symptoms. CONCLUSION: PNIF is a helpful and feasible tool for 
      conducting provocation trials with allergens, especially grass pollen and house 
      dust mite, in an AEC.
FAU - Boelke, Georg
AU  - Boelke G
AUID- ORCID: 0000-0003-1214-1671
AD  - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat 
      Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, 
      Department of Dermatology and Allergy, Allergy-Center-Charite, Berlin, Germany.
FAU - Berger, Uwe
AU  - Berger U
AD  - Department of Otorhinolaryngology, Aerobiology and Pollen Information Research 
      Unit, Medical University of Vienna, Vienna, Austria. ISNI: 0000 0000 9259 8492. 
      GRID: grid.22937.3d
FAU - Bergmann, Karl-Christian
AU  - Bergmann KC
AD  - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat 
      Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, 
      Department of Dermatology and Allergy, Allergy-Center-Charite, Berlin, Germany.
FAU - Bindslev-Jensen, Carsten
AU  - Bindslev-Jensen C
AD  - Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, 
      Denmark. ISNI: 0000 0004 0512 5013. GRID: grid.7143.1
FAU - Bousquet, Jean
AU  - Bousquet J
AD  - CHRU, Montpellier University Hospital Center, Montpellier, France. ISNI: 0000 
      0000 9961 060X. GRID: grid.157868.5
FAU - Gildemeister, Julia
AU  - Gildemeister J
AD  - Mobile Chamber Experts GmbH, Berlin, Germany.
FAU - Jutel, Marek
AU  - Jutel M
AD  - ALL-MED Medical Research Institute, Wroclaw, Poland.
AD  - Department of Clinical Immunology, Wroclaw Medical University, Wroclaw, Poland. 
      ISNI: 0000 0001 1090 049X. GRID: grid.4495.c
FAU - Pfaar, Oliver
AU  - Pfaar O
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, Universitatsmedizin 
      Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 
      ISNI: 0000 0001 2190 4373. GRID: grid.7700.0
AD  - Center for Rhinology and Allergology, Wiesbaden, Germany.
FAU - Sehlinger, Torsten
AU  - Sehlinger T
AD  - Bluestone Technology GmbH, Woerrstadt, Germany.
FAU - Zuberbier, Torsten
AU  - Zuberbier T
AD  - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat 
      Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health, 
      Department of Dermatology and Allergy, Allergy-Center-Charite, Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20170917
PL  - England
TA  - Clin Transl Allergy
JT  - Clinical and translational allergy
JID - 101576043
PMC - PMC5604509
OTO - NOTNLM
OT  - Allergen exposure chamber (AEC)
OT  - Allergy trial
OT  - GA2LEN chamber
OT  - Peak nasal inspiratory flow (PNIF)
OT  - Provocation study
EDAT- 2017/09/22 06:00
MHDA- 2017/09/22 06:01
PMCR- 2017/09/17
CRDT- 2017/09/22 06:00
PHST- 2017/07/02 00:00 [received]
PHST- 2017/09/04 00:00 [accepted]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/09/22 06:01 [medline]
PHST- 2017/09/17 00:00 [pmc-release]
AID - 169 [pii]
AID - 10.1186/s13601-017-0169-4 [doi]
PST - epublish
SO  - Clin Transl Allergy. 2017 Sep 17;7:33. doi: 10.1186/s13601-017-0169-4. 
      eCollection 2017.