PMID- 28933048
OWN - NLM
STAT- MEDLINE
DCOM- 20190131
LR  - 20211204
IS  - 1476-3524 (Electronic)
IS  - 1029-8428 (Print)
IS  - 1029-8428 (Linking)
VI  - 33
IP  - 2
DP  - 2018 Feb
TI  - Delta-9-Tetrahydrocannabinol (∆(9)-THC) Induce Neurogenesis and Improve Cognitive 
      Performances of Male Sprague Dawley Rats.
PG  - 402-411
LID - 10.1007/s12640-017-9806-x [doi]
AB  - Neurogenesis is influenced by various external factors such as enriched 
      environments. Some researchers had postulated that neurogenesis has contributed 
      to the hippocampal learning and memory. This project was designed to observe the 
      effect of Delta-9-tetrahydrocannabinol (∆(9)-THC) in cognitive performance that 
      influenced by the neurogenesis. Different doses of ∆(9)-THC were used for 
      observing the neurogenesis mechanism occurs in the hippocampus of rats. The 
      brains were stained with antibodies, namely BrdU, glial fibrillary acidic protein 
      (GFAP), nestin, doublecortin (DCX) and class III beta-tubulin (TuJ-1). The cognitive 
      test was used novel-object discrimination test (NOD) while the proteins involved, 
      DCX and brain-derived neurotrophic factor (BDNF), were measured. Throughout this 
      study, ∆(9)-THC enhanced the markers involved in all stages of neurogenesis 
      mechanism. Simultaneously, the cognitive behaviour of rat also showed improvement 
      in learning and memory functions observed in behavioural test and molecular 
      perspective. Administration of ∆(9)-THC was observed to enhance the neurogenesis 
      in the brain, especially in hippocampus thus improved the cognitive function of 
      rats.
FAU - Suliman, Noor Azuin
AU  - Suliman NA
AD  - Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
FAU - Taib, Che Norma Mat
AU  - Taib CNM
AUID- ORCID: 0000-0002-4534-5614
AD  - Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, 43400, Serdang, Selangor, Malaysia. chenorma@upm.edu.my.
FAU - Moklas, Mohamad Aris Mohd
AU  - Moklas MAM
AD  - Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
FAU - Basir, Rusliza
AU  - Basir R
AD  - Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti 
      Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
LA  - eng
GR  - 04-02-11-1374RU/Ministry of Higher Education, Malaysia/International
GR  - 04-04-10-841FR/Ministry of Higher Education, Malaysia/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170921
PL  - United States
TA  - Neurotox Res
JT  - Neurotoxicity research
JID - 100929017
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dcx protein, rat)
RN  - 0 (Doublecortin Protein)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Nestin)
RN  - 7J8897W37S (Dronabinol)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition/*drug effects
MH  - Doublecortin Protein
MH  - Dronabinol/*pharmacology
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Hippocampus/*drug effects
MH  - Male
MH  - Maze Learning/drug effects
MH  - Memory/*drug effects
MH  - Nestin/metabolism
MH  - Neurogenesis/*drug effects
MH  - Rats, Sprague-Dawley
PMC - PMC5766723
OTO - NOTNLM
OT  - Cognitive function
OT  - Delta-9-tetrahydrocannabinol
OT  - Hippocampal neurogenesis
OT  - Novel-object discrimination test
COIS- The authors declare that they have no competing interests.
EDAT- 2017/09/22 06:00
MHDA- 2019/02/01 06:00
PMCR- 2017/09/21
CRDT- 2017/09/22 06:00
PHST- 2016/12/21 00:00 [received]
PHST- 2017/08/23 00:00 [accepted]
PHST- 2017/08/11 00:00 [revised]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2019/02/01 06:00 [medline]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/21 00:00 [pmc-release]
AID - 10.1007/s12640-017-9806-x [pii]
AID - 9806 [pii]
AID - 10.1007/s12640-017-9806-x [doi]
PST - ppublish
SO  - Neurotox Res. 2018 Feb;33(2):402-411. doi: 10.1007/s12640-017-9806-x. Epub 2017 
      Sep 21.