PMID- 28933284
OWN - NLM
STAT- MEDLINE
DCOM- 20190620
LR  - 20190620
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 26
IP  - 8
DP  - 2019
TI  - Enzyme-Instructed Self-assembly in Biological Milieu for Theranostics Purpose.
PG  - 1351-1365
LID - 10.2174/0929867324666170921104010 [doi]
AB  - Precision medicine is in an urgent need for public healthcare. Among the past 
      several decades, the flourishing development in nanotechnology significantly 
      advances the realization of precision nanomedicine. Comparing to well-documented 
      nanoparticlebased strategy, in this review, we focus on the strategy using enzyme 
      instructed selfassembly (EISA) in biological milieu for theranostics purpose. In 
      principle, the design of small molecules for EISA requires two aspects: (1) the 
      substrate of enzyme of interest; and (2) self-assembly potency after enzymatic 
      conversion. This strategy has shown its irreplaceable advantages in nanomedicne, 
      specifically for cancer treatments and Vaccine Adjuvants. Interestingly, all the 
      reported examples rely on only one kind of enzymehydrolase. Therefore, we 
      envision that the application of EISA strategy just begins and will lead to a new 
      paradigm in nanomedicine.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Huang, Zhentao
AU  - Huang Z
AD  - Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory 
      for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence 
      in Nanoscience, National Center for NanoScience and Technology, No. 11 
      Zhongguancun Beiyitiao, Beijing 100190, China.
FAU - Yao, Qingxin
AU  - Yao Q
AD  - Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory 
      for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence 
      in Nanoscience, National Center for NanoScience and Technology, No. 11 
      Zhongguancun Beiyitiao, Beijing 100190, China.
FAU - Wei, Simin
AU  - Wei S
AD  - Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory 
      for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence 
      in Nanoscience, National Center for NanoScience and Technology, No. 11 
      Zhongguancun Beiyitiao, Beijing 100190, China.
FAU - Chen, Jiali
AU  - Chen J
AD  - Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory 
      for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence 
      in Nanoscience, National Center for NanoScience and Technology, No. 11 
      Zhongguancun Beiyitiao, Beijing 100190, China.
FAU - Gao, Yuan
AU  - Gao Y
AD  - Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory 
      for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence 
      in Nanoscience, National Center for NanoScience and Technology, No. 11 
      Zhongguancun Beiyitiao, Beijing 100190, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Hydrogels)
RN  - 0 (Small Molecule Libraries)
SB  - IM
MH  - Adjuvants, Immunologic/chemistry/metabolism/therapeutic use
MH  - Animals
MH  - Biocatalysis
MH  - Dimerization
MH  - Humans
MH  - Hydrogels/chemistry/*metabolism/*therapeutic use
MH  - Nanostructures/chemistry/therapeutic use
MH  - Neoplasms/diagnosis/metabolism/*therapy
MH  - Precision Medicine/methods
MH  - Small Molecule Libraries/chemistry/*metabolism/*therapeutic use
MH  - Substrate Specificity
MH  - Theranostic Nanomedicine/*methods
OTO - NOTNLM
OT  - Enzyme
OT  - Nanotechnology
OT  - Precision medicine
OT  - Self-assembly
OT  - Theranostics
OT  - Vaccine adjuvants.
EDAT- 2017/09/22 06:00
MHDA- 2019/06/21 06:00
CRDT- 2017/09/22 06:00
PHST- 2017/01/01 00:00 [received]
PHST- 2017/06/19 00:00 [revised]
PHST- 2017/06/19 00:00 [accepted]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2019/06/21 06:00 [medline]
PHST- 2017/09/22 06:00 [entrez]
AID - CMC-EPUB-85926 [pii]
AID - 10.2174/0929867324666170921104010 [doi]
PST - ppublish
SO  - Curr Med Chem. 2019;26(8):1351-1365. doi: 10.2174/0929867324666170921104010.