PMID- 28933564
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20190124
IS  - 1475-6374 (Electronic)
IS  - 1475-6366 (Print)
IS  - 1475-6366 (Linking)
VI  - 32
IP  - 1
DP  - 2017 Dec
TI  - alpha-Glucosidase inhibition by flavonoids: an in vitro and in silico 
      structure-activity relationship study.
PG  - 1216-1228
LID - 10.1080/14756366.2017.1368503 [doi]
AB  - alpha-Glucosidase inhibitors are described as the most effective in reducing 
      post-prandial hyperglycaemia (PPHG) from all available anti-diabetic drugs used 
      in the management of type 2 diabetes mellitus. As flavonoids are promising 
      modulators of this enzyme's activity, a panel of 44 flavonoids, organised in five 
      groups, was screened for their inhibitory activity of alpha-glucosidase, based on in 
      vitro structure-activity relationship studies. Inhibitory kinetic analysis and 
      molecular docking calculations were also applied for selected compounds. A 
      flavonoid with two catechol groups in A- and B-rings, together with a 3-OH group 
      at C-ring, was the most active, presenting an IC(50) much lower than the one 
      found for the most widely prescribed alpha-glucosidase inhibitor, acarbose. The 
      present work suggests that several of the studied flavonoids have the potential 
      to be used as alternatives for the regulation of PPHG.
FAU - Proenca, Carina
AU  - Proenca C
AD  - a UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical 
      Sciences, Faculty of Pharmacy , University of Porto , Porto , Portugal.
FAU - Freitas, Marisa
AU  - Freitas M
AD  - a UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical 
      Sciences, Faculty of Pharmacy , University of Porto , Porto , Portugal.
FAU - Ribeiro, Daniela
AU  - Ribeiro D
AD  - a UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical 
      Sciences, Faculty of Pharmacy , University of Porto , Porto , Portugal.
FAU - Oliveira, Eduardo F T
AU  - Oliveira EFT
AD  - b UCIBIO, REQUIMTE, Faculty of Sciences, Department of Chemistry and Biochemistry 
      , University of Porto , Porto , Portugal.
FAU - Sousa, Joana L C
AU  - Sousa JLC
AD  - c Department of Chemistry & QOPNA , University of Aveiro , Aveiro , Portugal.
FAU - Tome, Sara M
AU  - Tome SM
AD  - c Department of Chemistry & QOPNA , University of Aveiro , Aveiro , Portugal.
FAU - Ramos, Maria J
AU  - Ramos MJ
AD  - b UCIBIO, REQUIMTE, Faculty of Sciences, Department of Chemistry and Biochemistry 
      , University of Porto , Porto , Portugal.
FAU - Silva, Artur M S
AU  - Silva AMS
AD  - c Department of Chemistry & QOPNA , University of Aveiro , Aveiro , Portugal.
FAU - Fernandes, Pedro A
AU  - Fernandes PA
AD  - b UCIBIO, REQUIMTE, Faculty of Sciences, Department of Chemistry and Biochemistry 
      , University of Porto , Porto , Portugal.
FAU - Fernandes, Eduarda
AU  - Fernandes E
AUID- ORCID: 0000-0001-6424-0976
AD  - a UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical 
      Sciences, Faculty of Pharmacy , University of Porto , Porto , Portugal.
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Enzyme Inhib Med Chem
JT  - Journal of enzyme inhibition and medicinal chemistry
JID - 101150203
RN  - 0 (Flavonoids)
RN  - 0 (Glycoside Hydrolase Inhibitors)
RN  - EC 3.2.1.20 (alpha-Glucosidases)
RN  - T58MSI464G (Acarbose)
SB  - IM
MH  - Acarbose/chemistry/pharmacology
MH  - *Computer Simulation
MH  - Dose-Response Relationship, Drug
MH  - Flavonoids/chemistry/*pharmacology
MH  - Glycoside Hydrolase Inhibitors/*chemistry/*pharmacology
MH  - *Molecular Docking Simulation
MH  - Molecular Structure
MH  - Saccharomyces cerevisiae/enzymology
MH  - Structure-Activity Relationship
MH  - alpha-Glucosidases/*metabolism
PMC - PMC6009965
OTO - NOTNLM
OT  - Diabetes
OT  - flavonoids
OT  - in silico
OT  - in vitro
OT  - alpha-glucosidase inhibition
EDAT- 2017/09/22 06:00
MHDA- 2017/10/11 06:00
PMCR- 2017/09/21
CRDT- 2017/09/22 06:00
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2017/09/21 00:00 [pmc-release]
AID - 1368503 [pii]
AID - 10.1080/14756366.2017.1368503 [doi]
PST - ppublish
SO  - J Enzyme Inhib Med Chem. 2017 Dec;32(1):1216-1228. doi: 
      10.1080/14756366.2017.1368503.