PMID- 28933745
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20181113
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 9
IP  - 8
DP  - 2017 Jul 26
TI  - Effects of Six-Week Ginkgo biloba Supplementation on Aerobic Performance, Blood 
      Pro/Antioxidant Balance, and Serum Brain-Derived Neurotrophic Factor in 
      Physically Active Men.
LID - 10.3390/nu9080803 [doi]
LID - 803
AB  - Extracts of Ginkgo biloba leaves, a natural source of flavonoids and polyphenolic 
      compounds, are commonly used as therapeutic agents for the improvement of both 
      cognitive and physiological performance. The present study was aimed to test the 
      effects of a six-week supplementation with 160 mg/day of a standardized extract 
      of Ginkgo biloba or a matching placebo on aerobic performance, blood antioxidant 
      capacity, and brain-derived neurotrophic factor (BDNF) level in healthy, 
      physically active young men, randomly allocated to two groups (n = 9 each). At 
      baseline, as well as on the day following the treatment, the participants 
      performed an incremental cycling test for the assessment of maximal oxygen 
      uptake. Venous blood samples taken at rest, then immediately post-test and 
      following 1 h of recovery, were analyzed for activities of antioxidant enzymes 
      and plasma concentrations of non-enzymatic antioxidants, total phenolics, uric 
      acid, lipid peroxidation products, ferric reducing ability of plasma (FRAP), and 
      serum brain-derived neurotrophic factor (BDNF). Our results show that six weeks' 
      supplementation with Ginkgo biloba extract in physically active young men may 
      provide some marginal improvements in their endurance performance expressed as 
      VO(2)max and blood antioxidant capacity, as evidenced by specific biomarkers, and 
      elicit somewhat better neuroprotection through increased exercise-induced 
      production of BDNF.
FAU - Sadowska-Krepa, Ewa
AU  - Sadowska-Krepa E
AD  - Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of 
      Physical Education, 40-065 Katowice, Poland. e.sadowska-krepa@awf.katowice.pl.
FAU - Klapcinska, Barbara
AU  - Klapcinska B
AD  - Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of 
      Physical Education, 40-065 Katowice, Poland. b.klapcinska@awf.katowice.pl.
FAU - Pokora, Ilona
AU  - Pokora I
AD  - Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of 
      Physical Education, 40-065 Katowice, Poland. i.pokora@awf.katowice.pl.
FAU - Domaszewski, Przemyslaw
AU  - Domaszewski P
AD  - Department of Tourism and Health Promotion, University of Technology, Faculty of 
      Physical Education and Physiotherapy, 45-758 Opole, Poland. 
      domaszewskiprzemek@wp.pl.
FAU - Kempa, Katarzyna
AU  - Kempa K
AD  - Department of Physiological and Medical Sciences, The Jerzy Kukuczka Academy of 
      Physical Education, 40-065 Katowice, Poland. k.kempa@awf.katowice.pl.
FAU - Podgorski, Tomasz
AU  - Podgorski T
AD  - Department of Biochemistry, Poznan University of Physical Education, 61-871 
      Poznan, Poland. podgorski@awf.poznan.pl.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170726
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Plant Extracts)
RN  - 19FUJ2C58T (Ginkgo biloba extract)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Antioxidants/*metabolism
MH  - Bicycling
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - *Dietary Supplements
MH  - Drug Administration Schedule
MH  - Exercise Test
MH  - *Ginkgo biloba/chemistry
MH  - Humans
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Oxygen Consumption/drug effects
MH  - Physical Endurance/*drug effects
MH  - *Physical Fitness
MH  - Phytotherapy
MH  - Plant Extracts/*administration & dosage/isolation & purification
MH  - Plant Leaves
MH  - Plants, Medicinal
MH  - Poland
MH  - Time Factors
MH  - Young Adult
PMC - PMC5579597
OTO - NOTNLM
OT  - BDNF
OT  - Ginkgo biloba extract
OT  - antioxidant capacity
OT  - dietary supplements
COIS- The authors declare no conflicts of interest.
EDAT- 2017/09/22 06:00
MHDA- 2018/05/08 06:00
PMCR- 2017/08/01
CRDT- 2017/09/22 06:00
PHST- 2017/05/11 00:00 [received]
PHST- 2017/07/11 00:00 [revised]
PHST- 2017/07/24 00:00 [accepted]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/08/01 00:00 [pmc-release]
AID - nu9080803 [pii]
AID - nutrients-09-00803 [pii]
AID - 10.3390/nu9080803 [doi]
PST - epublish
SO  - Nutrients. 2017 Jul 26;9(8):803. doi: 10.3390/nu9080803.