PMID- 28934191
OWN - NLM
STAT- MEDLINE
DCOM- 20180522
LR  - 20181113
IS  - 2158-3188 (Electronic)
IS  - 2158-3188 (Linking)
VI  - 7
IP  - 7
DP  - 2017 Jul 18
TI  - Effects of aerobic exercise on brain metabolism and grey matter volume in older 
      adults: results of the randomised controlled SMART trial.
PG  - e1172
LID - 10.1038/tp.2017.135 [doi]
AB  - There is mounting evidence that aerobic exercise has a positive effect on 
      cognitive functions in older adults. To date, little is known about the 
      neurometabolic and molecular mechanisms underlying this positive effect. The 
      present study used magnetic resonance spectroscopy and quantitative MRI to 
      systematically explore the effects of physical activity on human brain metabolism 
      and grey matter (GM) volume in healthy aging. This is a randomised controlled 
      assessor-blinded two-armed trial (n=53) to explore exercise-induced 
      neuroprotective and metabolic effects on the brain in cognitively healthy older 
      adults. Participants (age >65) were allocated to a 12-week individualised aerobic 
      exercise programme intervention (n=29) or a 12-week waiting control group (n=24). 
      The main outcomes were the change in cerebral metabolism and its association to 
      brain-derived neurotrophic factor (BDNF) levels as well as changes in GM volume. 
      We found that cerebral choline concentrations remained stable after 12 weeks of 
      aerobic exercise in the intervention group, whereas they increased in the waiting 
      control group. No effect of training was seen on cerebral N-acetyl-aspartate 
      concentrations, nor on markers of neuronal energy reserve or BDNF levels. 
      Further, we observed no change in cortical GM volume in response to aerobic 
      exercise. The finding of stable choline concentrations in the intervention group 
      over the 3 month period might indicate a neuroprotective effect of aerobic 
      exercise. Choline might constitute a valid marker for an effect of aerobic 
      exercise on cerebral metabolism in healthy aging.
FAU - Matura, S
AU  - Matura S
AD  - Institute of General Practice, Goethe University, Frankfurt/Main, Germany.
FAU - Fleckenstein, J
AU  - Fleckenstein J
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt/Main, Germany.
FAU - Deichmann, R
AU  - Deichmann R
AD  - Brain Imaging Center, Frankfurt/Main, Germany.
FAU - Engeroff, T
AU  - Engeroff T
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt/Main, Germany.
FAU - Fuzeki, E
AU  - Fuzeki E
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt/Main, Germany.
FAU - Hattingen, E
AU  - Hattingen E
AD  - Institute of Neuroradiology, Goethe University Hospital Frankfurt, 
      Frankfurt/Main, Germany.
FAU - Hellweg, R
AU  - Hellweg R
AD  - Neurobiology and Neurotrophins Laboratory, Department of Psychiatry and 
      Psychotherapy, Charite University Medicine, Berlin, Germany.
FAU - Lienerth, B
AU  - Lienerth B
AD  - Brain Imaging Center, Frankfurt/Main, Germany.
FAU - Pilatus, U
AU  - Pilatus U
AD  - Institute of Neuroradiology, Goethe University Hospital Frankfurt, 
      Frankfurt/Main, Germany.
FAU - Schwarz, S
AU  - Schwarz S
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt/Main, Germany.
FAU - Tesky, V A
AU  - Tesky VA
AD  - Institute of General Practice, Goethe University, Frankfurt/Main, Germany.
FAU - Vogt, L
AU  - Vogt L
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt/Main, Germany.
FAU - Banzer, W
AU  - Banzer W
AD  - Department of Sports Medicine, Institute of Sports Sciences, Goethe University, 
      Frankfurt/Main, Germany.
FAU - Pantel, J
AU  - Pantel J
AD  - Institute of General Practice, Goethe University, Frankfurt/Main, Germany.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170718
PL  - United States
TA  - Transl Psychiatry
JT  - Translational psychiatry
JID - 101562664
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Choline/metabolism
MH  - *Exercise
MH  - Female
MH  - Gray Matter/*anatomy & histology/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy
MH  - Male
PMC - PMC5538117
COIS- The authors declare no conflict of interest.
EDAT- 2017/09/22 06:00
MHDA- 2018/05/23 06:00
PMCR- 2017/07/01
CRDT- 2017/09/22 06:00
PHST- 2016/12/16 00:00 [received]
PHST- 2017/04/21 00:00 [revised]
PHST- 2017/05/08 00:00 [accepted]
PHST- 2017/09/22 06:00 [entrez]
PHST- 2017/09/22 06:00 [pubmed]
PHST- 2018/05/23 06:00 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - tp2017135 [pii]
AID - 10.1038/tp.2017.135 [doi]
PST - epublish
SO  - Transl Psychiatry. 2017 Jul 18;7(7):e1172. doi: 10.1038/tp.2017.135.