PMID- 28935459
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20200502
IS  - 1535-6302 (Electronic)
IS  - 0363-0188 (Linking)
VI  - 47
IP  - 5
DP  - 2018 Sep
TI  - Clinical and Pathologic Features of Clinically Occult Synchronous Bilateral 
      Breast Cancers.
PG  - 305-310
LID - S0363-0188(17)30150-0 [pii]
LID - 10.1067/j.cpradiol.2017.08.002 [doi]
AB  - PURPOSE: To investigate clinicopathologic breast cancer characteristics 
      associated with the identification of synchronous bilateral breast cancer (SBBC) 
      on dynamic contrast-enhanced breast magnetic resonance imaging. METHODS: We 
      performed a retrospective review of 311 consecutive patients newly diagnosed with 
      breast cancer who underwent diagnostic mammography, ultrasonography, and dynamic 
      contrast-enhanced breast magnetic resonance imaging (DCE-MRI) at our institution. 
      Tumor histology, grade, biomarker status (estrogen receptor, progesterone 
      receptor, and HER2), TNM staging, and unifocal or multifocal/multicentric status 
      were compared between the index tumors in the unilateral disease and the SBBC 
      groups, as well as between the index tumors in the unilateral disease group and 
      the synchronous contralateral tumors (SCT) in the SBBC group, using the Fisher 
      exact test. RESULTS: A total of 326 cancers in 311 patients were reviewed. 
      Fifteen (4.8%) patients were diagnosed with SBBC. The index tumors in patients 
      with SBBC were more frequently lower T stage (p = 0.007), lower grade (p = 0.04), 
      and multifocal/multicentric (p = 0.004) compared with the index tumors in the 
      unilateral group. Biomarkers, N status, and M status did not significantly differ 
      between the index tumors in both groups. CONCLUSIONS: SBBC was more likely to be 
      identified in women with lower T stage, lower tumor grade and 
      multifocal/multicentric tumors. Multimodality imaging including DCE-MRI is 
      essential in detection and diagnosis of SBBC.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Santiago, Lumarie
AU  - Santiago L
AD  - Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX. Electronic address: Lumarie.Santiago@mdanderson.org.
FAU - Whitman, Gary
AU  - Whitman G
AD  - Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX.
FAU - Wang, Cuiyan
AU  - Wang C
AD  - Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer 
      Center, Houston, TX; Shandong Medical Imaging Research Institute, Shandong 
      University, Jinan, Shandong, China.
FAU - Dogan, Basak E
AU  - Dogan BE
AD  - Department of Diagnostic Radiology, The University of Texas Southwestern Medical 
      Center, Dallas, TX.
LA  - eng
PT  - Journal Article
DEP - 20170824
PL  - United States
TA  - Curr Probl Diagn Radiol
JT  - Current problems in diagnostic radiology
JID - 7607123
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/analysis
MH  - Breast Neoplasms/*diagnostic imaging/*pathology
MH  - Contrast Media
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Mammography
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Neoplasms, Multiple Primary/*diagnostic imaging/*pathology
MH  - Ultrasonography, Mammary
EDAT- 2017/09/25 06:00
MHDA- 2018/11/27 06:00
CRDT- 2017/09/23 06:00
PHST- 2017/06/06 00:00 [received]
PHST- 2017/07/31 00:00 [revised]
PHST- 2017/08/21 00:00 [accepted]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2017/09/23 06:00 [entrez]
AID - S0363-0188(17)30150-0 [pii]
AID - 10.1067/j.cpradiol.2017.08.002 [doi]
PST - ppublish
SO  - Curr Probl Diagn Radiol. 2018 Sep;47(5):305-310. doi: 
      10.1067/j.cpradiol.2017.08.002. Epub 2017 Aug 24.