PMID- 28935854
OWN - NLM
STAT- MEDLINE
DCOM- 20180109
LR  - 20190609
IS  - 1941-5923 (Electronic)
IS  - 1941-5923 (Linking)
VI  - 18
DP  - 2017 Sep 22
TI  - Comparison of Helical Tomotherapy and Direct Tomotherapy in Bilateral Whole 
      Breast Irradiation in a Case of Bilateral Synchronous Grade 1 and Stage 1 Breast 
      Cancer.
PG  - 1020-1023
AB  - BACKGROUND Synchronous bilateral breast cancer is rare. A case is presented where 
      whole breast irradiation (WBI) was planned after breast conserving surgery in a 
      patient with synchronous bilateral breast cancer. A comparison was made between 
      the feasibility of helical tomotherapy and direct tomotherapy. CASE REPORT A 
      60-year-old woman was found to have bilateral breast nodules on routine 
      mammographic screening, resulting in bilateral lumpectomy and sentinel lymph node 
      biopsy. Histopathology showed a 6 mm diameter invasive ductal carcinoma in the 
      right breast (Grade 1, hormone receptor positive, HER2 negative) and an 8mm 
      diameter tubular carcinoma in the left breast (Grade 1, hormone receptor 
      positive, HER2 negative). Lymph node biopsy and histology, chest X-ray, abdominal 
      ultrasound scan, and bone scintigraphy were negative for metastases (both tumors 
      were Stage 1). Adjuvant therapy with commenced with anastrozole, but no 
      chemotherapy was given. Clinical target volumes (CTVs) were contoured on computed 
      tomography (CT) images. For planning target volumes (PTVs), CTVs were expanded by 
      1 cm in all directions, except for the medial 5 mm. Since dose constraints to 
      organs at risk (OARs) were beyond established limits, CTVs were expanded by 5 mm. 
      For PTVs, OAR doses and homogeneity indices for helical tomotherapy and direct 
      tomotherapy were compared. Helical tomotherapy provided better target volume 
      coverage and OAR sparing than direct tomotherapy. CONCLUSIONS In a case of 
      bilateral synchronous Stage 1 and Grade 1 breast cancer, helical tomotherapy 
      appeared more suitable than direct tomotherapy.
FAU - Lancellotta, Valentina
AU  - Lancellotta V
AD  - Radiation Oncology Section, Department of Surgical and Biomedical Science, 
      University of Perugia and Perugia General Hospital, Perugia, Italy.
FAU - Iacco, Martina
AU  - Iacco M
AD  - Medical Physics Unit, Perugia General Hospital, Perugia, Italy.
FAU - Perrucci, Elisabetta
AU  - Perrucci E
AD  - Radiation Oncology Division, Perugia General Hospital, Perugia, Italy.
FAU - Zucchetti, Claudio
AU  - Zucchetti C
AD  - Medical Physics Unit, Perugia General Hospital, Perugia, Italy.
FAU - Dipilato, Anna Concetta
AU  - Dipilato AC
AD  - Medical Physics Unit, Perugia General Hospital, Perugia, Italy.
FAU - Falcinelli, Lorenzo
AU  - Falcinelli L
AD  - Radiation Oncology Division, Perugia General Hospital, Perugia, Italy.
FAU - Palumbo, Isabella
AU  - Palumbo I
AD  - Radiation Oncology Section, Department of Surgical and Biomedical Science, 
      University of Perugia, Perugia General Hospital, Perugia, Italy.
FAU - Aristei, Cynthia
AU  - Aristei C
AD  - Radiation Oncology Section, Department of Surgical and Biomedical Science, 
      University of Perugia, Perugia General Hospital, Perugia, Italy.
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
DEP - 20170922
PL  - United States
TA  - Am J Case Rep
JT  - The American journal of case reports
JID - 101489566
SB  - IM
MH  - Breast Neoplasms/pathology/*therapy
MH  - Carcinoma, Ductal, Breast/pathology/therapy
MH  - Female
MH  - Humans
MH  - Mastectomy, Segmental
MH  - Middle Aged
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Radiotherapy, Adjuvant/*methods
MH  - *Radiotherapy, Intensity-Modulated
PMC - PMC5627865
COIS- Conflict of interest: None declared Conflict of interest None.
EDAT- 2017/09/25 06:00
MHDA- 2018/01/10 06:00
PMCR- 2017/09/22
CRDT- 2017/09/23 06:00
PHST- 2017/09/23 06:00 [entrez]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2018/01/10 06:00 [medline]
PHST- 2017/09/22 00:00 [pmc-release]
AID - 905245 [pii]
AID - 10.12659/ajcr.905245 [doi]
PST - epublish
SO  - Am J Case Rep. 2017 Sep 22;18:1020-1023. doi: 10.12659/ajcr.905245.