PMID- 28936576 OWN - NLM STAT- MEDLINE DCOM- 20180827 LR - 20181113 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 34 IP - 3 DP - 2018 Mar TI - Improvement of continuous subcutaneous insulin infusion on patients with type 2 diabetes mellitus by 3-dimensional speckle tracking echocardiography. PG - 379-384 LID - 10.1007/s10554-017-1245-5 [doi] AB - Three-dimensional speckle tracking echocardiography (3D-STE) was used to evaluate the improvement of continuous subcutaneous insulin infusion on the left ventricular (LV) systolic function of patients with type 2 diabetes mellitu (T2DM). We recruited T2DM patients (38 cases, diabetic group) and healthy volunteers (35 cases, control group) to collect LV full volume imaging. TomTec software was used for calculating LV global longitudinal strain (LVGLS), global circumferential strain (LVGCS), peak twist (LVTW), peak apical rotation (LVPAR), ejection fraction (LVEF), and torsion (LVT). All indices were re-tested 2 weeks later after intensive treatment of insulin pump. LVGLS, LVGCS, LVTW and LVPAR in diabetic group were significantly decreased than control group. LVGLS and LVGCS in pre-treatment diabetic group were significantly increased than post-treatment. LVGLS, LVGCS, LVTW and LVPAR had correlations among control, pre-treatment and post-treatment diabetic groups. There were no significant differences in LVEDV, LVESV, LVEF, LVT and R-R. LV systolic function of patients with T2DM complicated with microangiopathy was improved after treatment of continuous subcutaneous insulin infusion. In addition, therapeutic effect could be accurately evaluated by 3D-STE which had vital clinical application. FAU - Luo, Hong-Xia AU - Luo HX AD - Department of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, No.109 Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang, China. FAU - Zhou, Xiao-Ling AU - Zhou XL AD - Department of Medical Ultrasound, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. FAU - Kou, Hong-Ju AU - Kou HJ AD - Department of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, No.109 Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang, China. FAU - Ni, Xian-Wei AU - Ni XW AD - Department of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, No.109 Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang, China. FAU - Wu, Qing AU - Wu Q AD - Department of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, No.109 Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang, China. FAU - Zou, Chun-Peng AU - Zou CP AD - Department of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, No.109 Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang, China. FAU - Wu, Dao-Zhu AU - Wu DZ AD - Department of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, No.109 Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang, China. wdz6276@163.com. FAU - Liu, Yong-Fang AU - Liu YF AD - Department of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, No.109 Xueyuan West Road, Lucheng District, Wenzhou, 325000, Zhejiang, China. liuyongfang0616@126.com. LA - eng PT - Journal Article DEP - 20170921 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) SB - IM MH - Adult MH - Aged MH - Case-Control Studies MH - Diabetes Mellitus, Type 2/complications/diagnosis/*drug therapy MH - *Echocardiography, Three-Dimensional MH - Female MH - Humans MH - Hypoglycemic Agents/*administration & dosage MH - Infusions, Subcutaneous MH - Insulin/*administration & dosage MH - Insulin Infusion Systems MH - Male MH - Middle Aged MH - Observer Variation MH - Predictive Value of Tests MH - Recovery of Function MH - Reproducibility of Results MH - Time Factors MH - Treatment Outcome MH - Ventricular Dysfunction, Left/*diagnostic imaging/etiology/physiopathology MH - *Ventricular Function, Left OTO - NOTNLM OT - Continuous subcutaneous insulin infusion OT - Global circumferential strain OT - Left ventricular global longitudinal strain OT - Three-dimensional speckle tracking echocardiography EDAT- 2017/09/25 06:00 MHDA- 2018/08/28 06:00 CRDT- 2017/09/23 06:00 PHST- 2017/06/01 00:00 [received] PHST- 2017/09/12 00:00 [accepted] PHST- 2017/09/25 06:00 [pubmed] PHST- 2018/08/28 06:00 [medline] PHST- 2017/09/23 06:00 [entrez] AID - 10.1007/s10554-017-1245-5 [pii] AID - 10.1007/s10554-017-1245-5 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2018 Mar;34(3):379-384. doi: 10.1007/s10554-017-1245-5. Epub 2017 Sep 21.