PMID- 28938610
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20170925
LR  - 20190116
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 35
DP  - 2017 Aug 29
TI  - Ghrelin produces antidepressant-like effect in the estrogen deficient mice.
PG  - 58964-58973
LID - 10.18632/oncotarget.19768 [doi]
AB  - Recent evidence shows that ghrelin plays an important role in depression. 
      However, it was little known whether ghrelin produces antidepressant-like effect 
      in the ovariectomized mice. The present study was aimed to investigate the 
      antidepressant-like effects of the ghrelin in ovariectomized mice. In the forced 
      swim test, ghrelin significantly decreased immobility time, reversing the 
      "depressive-like" effect observed in ovariectomized mice, and this effect was 
      reversed by the tamoxifen. In addition, immunohistochemical study indicated that 
      ghrelin treatment reversed the reductions in c-Fos expression induced by 
      ovariectomy. An estrogen antagonist tamoxifen also antagonized the effect of 
      ghrelin on the c-Fos expression. Furthermore, the western blotting indicated that 
      brain-derived neurotrophic factor (BDNF) in the hippocampus, but not 
      phosphorylated cAMP response element-binding protein (pCREB)/CREB in the frontal 
      cortex, were affected by ghrelin treatment. Ghrelin treatment significantly 
      increased BrdU expression. Therefore, these findings suggest that ghrelin 
      produces antidepressant-like effects in ovariectomized mice, and estrogen 
      receptor may be involved in the antidepressant-like effects of the ghrelin.
FAU - Fan, Jie
AU  - Fan J
AD  - Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second 
      Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
FAU - Li, Bing Jin
AU  - Li BJ
AD  - Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second 
      Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
FAU - Wang, Xue Feng
AU  - Wang XF
AD  - Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second 
      Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
FAU - Zhong, Li Li
AU  - Zhong LL
AD  - Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second 
      Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
FAU - Cui, Ran Ji
AU  - Cui RJ
AD  - Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second 
      Hospital of Jilin University, Changchun, Jilin 130041, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170801
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5601706
OTO - NOTNLM
OT  - antidepressant
OT  - depression
OT  - estrogen
OT  - ghrelin
OT  - ovariectomize
COIS- CONFLICTS OF INTEREST The authors declare no competing interest.
EDAT- 2017/09/25 06:00
MHDA- 2017/09/25 06:01
PMCR- 2017/08/29
CRDT- 2017/09/24 06:00
PHST- 2017/02/08 00:00 [received]
PHST- 2017/07/11 00:00 [accepted]
PHST- 2017/09/24 06:00 [entrez]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2017/09/25 06:01 [medline]
PHST- 2017/08/29 00:00 [pmc-release]
AID - 19768 [pii]
AID - 10.18632/oncotarget.19768 [doi]
PST - epublish
SO  - Oncotarget. 2017 Aug 1;8(35):58964-58973. doi: 10.18632/oncotarget.19768. 
      eCollection 2017 Aug 29.