PMID- 28939348
OWN - NLM
STAT- MEDLINE
DCOM- 20181010
LR  - 20181017
IS  - 1876-4754 (Electronic)
IS  - 1876-4754 (Linking)
VI  - 10
IP  - 6
DP  - 2017 Nov-Dec
TI  - Transcranial ultrasound stimulation promotes brain-derived neurotrophic factor 
      and reduces apoptosis in a mouse model of traumatic brain injury.
PG  - 1032-1041
LID - S1935-861X(17)30895-1 [pii]
LID - 10.1016/j.brs.2017.09.003 [doi]
AB  - BACKGROUND: The protein expressions of brain-derived neurotrophic factor (BDNF) 
      can be elevated by transcranial ultrasound stimulation in the rat brain. 
      OBJECTIVE: The purpose of this study was to investigate the effects and 
      underlying mechanisms of BDNF enhancement by low-intensity pulsed ultrasound 
      (LIPUS) on traumatic brain injury (TBI). METHODS: Mice subjected to controlled 
      cortical impact injury were treated with LIPUS in the injured region daily for a 
      period of 4 days. Western blot analysis and immunohistochemistry were performed 
      to assess the effects of LIPUS. RESULTS: The results showed that the LIPUS 
      treatment significantly promoted the neurotrophic factors BDNF and vascular 
      endothelial growth factor (VEGF) at day 4 after TBI. Meanwhile, LIPUS also 
      enhanced the phosphorylation of Tropomyosin-related kinase B (TrkB), Akt, and 
      cAMP-response element binding protein (CREB). Furthermore, treatment with LIPUS 
      significantly decreased the level of cleaved caspase-3. The reduction of 
      apoptotic process was inhibited by the anti-BDNF antibody. CONCLUSIONS: In short, 
      post-injury LIPUS treatment increased BDNF protein levels and inhibited the 
      progression of apoptosis following TBI. The neuroprotective effects of LIPUS may 
      be associated with enhancements of the protein levels of neurotrophic factors, at 
      least partially via the TrkB/Akt-CREB signaling pathway.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Su, Wei-Shen
AU  - Su WS
AD  - Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Wu, Chun-Hu
AU  - Wu CH
AD  - Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Chen, Szu-Fu
AU  - Chen SF
AD  - Departments of Physiology and Biophysics, National Defense Medical Center, 
      Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, Cheng Hsin 
      General Hospital, Taipei, Taiwan. Electronic address: szufuchen@yahoo.com.tw.
FAU - Yang, Feng-Yi
AU  - Yang FY
AD  - Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming 
      University, Taipei, Taiwan; Biophotonics and Molecular Imaging Research Center, 
      National Yang-Ming University, Taipei, Taiwan. Electronic address: 
      fyyang@ym.edu.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170907
PL  - United States
TA  - Brain Stimul
JT  - Brain stimulation
JID - 101465726
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Brain Injuries, Traumatic/*metabolism/therapy
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - *Disease Models, Animal
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Ultrasonic Therapy/*methods
MH  - *Ultrasonic Waves
OTO - NOTNLM
OT  - Apoptosis
OT  - BDNF
OT  - Neurotrophic factor
OT  - Traumatic brain injury
OT  - Ultrasound
EDAT- 2017/09/25 06:00
MHDA- 2018/10/12 06:00
CRDT- 2017/09/24 06:00
PHST- 2017/03/31 00:00 [received]
PHST- 2017/07/31 00:00 [revised]
PHST- 2017/09/02 00:00 [accepted]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2018/10/12 06:00 [medline]
PHST- 2017/09/24 06:00 [entrez]
AID - S1935-861X(17)30895-1 [pii]
AID - 10.1016/j.brs.2017.09.003 [doi]
PST - ppublish
SO  - Brain Stimul. 2017 Nov-Dec;10(6):1032-1041. doi: 10.1016/j.brs.2017.09.003. Epub 
      2017 Sep 7.