PMID- 28939875
OWN - NLM
STAT- MEDLINE
DCOM- 20190716
LR  - 20190716
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Sep 22
TI  - Dietary teasaponin ameliorates alteration of gut microbiota and cognitive decline 
      in diet-induced obese mice.
PG  - 12203
LID - 10.1038/s41598-017-12156-2 [doi]
LID - 12203
AB  - A high-fat (HF) diet alters gut microbiota and promotes obesity related 
      inflammation and cognitive impairment. Teasaponin is the major active component 
      of tea, and has been associated with anti-inflammatory effects and improved 
      microbiota composition. However, the potential protective effects of teasaponin, 
      against HF diet-induced obesity and its associated alteration of gut microbiota, 
      inflammation and cognitive decline have not been studied. In this study, obesity 
      was induced in C57BL/6 J male mice by feeding a HF diet for 8 weeks, followed by 
      treatment with oral teasaponin (0.5%) mixed in HF diet for a further 6 weeks. 
      Teasaponin treatment prevented the HF diet-induced recognition memory impairment 
      and improved neuroinflammation, gliosis and brain-derived neurotrophic factor 
      (BDNF) deficits in the hippocampus. Furthermore, teasaponin attenuated the HF 
      diet-induced endotoxemia, pro-inflammatory macrophage accumulation in the colon 
      and gut microbiota alterations. Teasaponin also improved glucose tolerance and 
      reduced body weight gain in HF diet-induced obese mice. The behavioral and 
      neurochemical improvements suggest that teasaponin could limit unfavorable gut 
      microbiota alterations and cognitive decline in HF diet-induced obesity.
FAU - Wang, Sen
AU  - Wang S
AD  - Illawarra Health and Medical Research Institute, School of Medicine, University 
      of Wollongong, Northfield Avenue, Wollongong, NSW 2522, Australia.
AD  - Department of Endocrinology and Metabolism, The people's hospital of Suzhou 
      National New & Hi-Tech Industrial development Zone, Suzhou, Jiangsu, 215011, 
      China.
FAU - Huang, Xu-Feng
AU  - Huang XF
AUID- ORCID: 0000-0002-5895-2253
AD  - Illawarra Health and Medical Research Institute, School of Medicine, University 
      of Wollongong, Northfield Avenue, Wollongong, NSW 2522, Australia. 
      xhuang@uow.edu.au.
AD  - Department of Pathogen Biology and Immunology, Jiangshu Key Laboratory of 
      Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, 
      China. xhuang@uow.edu.au.
FAU - Zhang, Peng
AU  - Zhang P
AD  - Illawarra Health and Medical Research Institute, School of Medicine, University 
      of Wollongong, Northfield Avenue, Wollongong, NSW 2522, Australia.
AD  - Department of Pathogen Biology and Immunology, Jiangshu Key Laboratory of 
      Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, 
      China.
FAU - Newell, Kelly A
AU  - Newell KA
AD  - Illawarra Health and Medical Research Institute, School of Medicine, University 
      of Wollongong, Northfield Avenue, Wollongong, NSW 2522, Australia.
FAU - Wang, Hongqin
AU  - Wang H
AD  - Illawarra Health and Medical Research Institute, School of Medicine, University 
      of Wollongong, Northfield Avenue, Wollongong, NSW 2522, Australia.
FAU - Zheng, Kuiyang
AU  - Zheng K
AD  - Department of Pathogen Biology and Immunology, Jiangshu Key Laboratory of 
      Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, 
      China.
FAU - Yu, Yinghua
AU  - Yu Y
AD  - Illawarra Health and Medical Research Institute, School of Medicine, University 
      of Wollongong, Northfield Avenue, Wollongong, NSW 2522, Australia. 
      yinghua@uow.edu.au.
AD  - Department of Pathogen Biology and Immunology, Jiangshu Key Laboratory of 
      Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, 
      China. yinghua@uow.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170922
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Saponins)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Camellia sinensis/*chemistry
MH  - Cognitive Dysfunction/*drug therapy/etiology/pathology
MH  - Diet, High-Fat/adverse effects
MH  - Disease Models, Animal
MH  - Endotoxemia
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Hippocampus/drug effects/pathology
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Obesity/complications/*drug therapy/etiology
MH  - Saponins/*administration & dosage
MH  - Weight Gain/drug effects
PMC - PMC5610180
COIS- The authors declare that they have no competing interests.
EDAT- 2017/09/25 06:00
MHDA- 2019/07/17 06:00
PMCR- 2017/09/22
CRDT- 2017/09/24 06:00
PHST- 2017/04/20 00:00 [received]
PHST- 2017/08/30 00:00 [accepted]
PHST- 2017/09/24 06:00 [entrez]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2019/07/17 06:00 [medline]
PHST- 2017/09/22 00:00 [pmc-release]
AID - 10.1038/s41598-017-12156-2 [pii]
AID - 12156 [pii]
AID - 10.1038/s41598-017-12156-2 [doi]
PST - epublish
SO  - Sci Rep. 2017 Sep 22;7(1):12203. doi: 10.1038/s41598-017-12156-2.