PMID- 28940173
OWN - NLM
STAT- MEDLINE
DCOM- 20180605
LR  - 20181202
IS  - 1976-3786 (Electronic)
IS  - 0253-6269 (Linking)
VI  - 40
IP  - 10
DP  - 2017 Oct
TI  - Liquiritigenin ameliorates memory and cognitive impairment through cholinergic 
      and BDNF pathways in the mouse hippocampus.
PG  - 1209-1217
LID - 10.1007/s12272-017-0954-6 [doi]
AB  - Liquiritigenin (LQ), a flavonoid extracted from the radix of Glycyrrhiza, has 
      anti-inflammatory and neuroprotective properties. In this study, we evaluated the 
      cognitive enhancing effects of LQ on learning and memory impairments induced by 
      scopolamine (0.5 mg/kg, i.p.), a muscarinic antagonist, using the Y-maze, passive 
      avoidance, and novel object recognition tests. A single administration of LQ 
      significantly improved scopolamine-induced cognitive impairments in these 
      behavioral tests. In addition, LQ dramatically inhibited acetylcholinesterase and 
      thiobarbituric acid reactive substance activities in the hippocampus of 
      scopolamine-induced mice in a dose-dependent manner. Furthermore, LQ markedly 
      increased the protein level of brain-derived neurotrophic factor (BDNF) and 
      phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP response 
      element binding (CREB) in the hippocampus of scopolamine-induced mice. Taken 
      together, our results indicate that LQ may be useful for the treatment of 
      learning and memory impairments, and that the beneficial effects of LQ are 
      mediated, in part, by cholinergic and BDNF/ERK/CREB signaling enhancement and/or 
      protection.
FAU - Ko, Yong-Hyun
AU  - Ko YH
AD  - Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 
      16419, Republic of Korea.
FAU - Kwon, Seung-Hwan
AU  - Kwon SH
AD  - Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 
      16419, Republic of Korea.
FAU - Lee, Seok-Yong
AU  - Lee SY
AD  - Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 
      16419, Republic of Korea.
FAU - Jang, Choon-Gon
AU  - Jang CG
AD  - Department of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 
      16419, Republic of Korea. jang@skku.edu.
LA  - eng
PT  - Journal Article
DEP - 20170922
PL  - Korea (South)
TA  - Arch Pharm Res
JT  - Archives of pharmacal research
JID - 8000036
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavanones)
RN  - 0 (Neuroprotective Agents)
RN  - DL48G20X8X (Scopolamine)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - T194LKP9W6 (liquiritigenin)
SB  - IM
MH  - Acetylcholinesterase/*metabolism
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cognitive Dysfunction/metabolism/*prevention & control
MH  - Disease Models, Animal
MH  - Flavanones/isolation & purification/*therapeutic use
MH  - Hippocampus/*drug effects/metabolism
MH  - Male
MH  - Memory Disorders/metabolism/*prevention & control
MH  - Mice, Inbred Strains
MH  - Neuroprotective Agents/isolation & purification/*therapeutic use
MH  - Scopolamine/administration & dosage
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Brain-derived neurotrophic factor
OT  - Extracellular signal-regulated kinase
OT  - Liquiritigenin
OT  - Scopolamine
OT  - cAMP response element binding
EDAT- 2017/09/25 06:00
MHDA- 2018/06/06 06:00
CRDT- 2017/09/24 06:00
PHST- 2017/06/22 00:00 [received]
PHST- 2017/09/08 00:00 [accepted]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2018/06/06 06:00 [medline]
PHST- 2017/09/24 06:00 [entrez]
AID - 10.1007/s12272-017-0954-6 [pii]
AID - 10.1007/s12272-017-0954-6 [doi]
PST - ppublish
SO  - Arch Pharm Res. 2017 Oct;40(10):1209-1217. doi: 10.1007/s12272-017-0954-6. Epub 
      2017 Sep 22.