PMID- 28940198
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20231112
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 191
IP  - 1
DP  - 2018 Jan
TI  - Complement regulatory proteins in kidneys of patients with anti-neutrophil 
      cytoplasmic antibody (ANCA)-associated vasculitis.
PG  - 116-124
LID - 10.1111/cei.13051 [doi]
AB  - The complement system activation is involved in the development of 
      anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). The study aimed 
      to investigate the expression of complement regulatory proteins (CRPs) CD46, CD55 
      and CD59 in kidneys of 51 AVV patients. The expression of CD46, CD55 and CD59 in 
      kidneys was detected by immunohistochemistry and double immunofluorescence 
      staining. The immunohistochemical examination revealed that expression of the 
      three CRPs could be detected in the glomeruli and tubules of both AAV patients 
      and normal controls. The expression levels of the three CRPs in glomeruli of 
      patients with AAV were significantly lower than those of normal controls. The 
      scores of CD46 and CD55 expression in the tubules of AAV patients were 
      significantly lower than those of normal controls, while there was no significant 
      difference between the scores of CD59 expression in tubules of AAV patients and 
      those of normal controls. Among AAV patients, the expression level of CD46 in 
      glomeruli correlated inversely with the proportion of normal glomeruli, while it 
      correlated with tubular atrophy in renal interstitium (r = -0.305, P = 0.026; 
      r = 0.330, P = 0.023, respectively). The expression levels of CD55 and CD59 in 
      glomeruli correlated with the proportion of total crescents (r = 0.384, 
      P = 0.006; r = 0.351, P = 0.011, respectively). Double immunofluorescence 
      staining indicated that all three CRPs were expressed on endothelial cells, 
      podocytes and mesangial cells in glomeruli. The expression levels of the three 
      CRPs were dysregulated in kidneys of patients with AAV. The expression levels of 
      CD46, CD55 and CD59 were associated with the severity of renal injury of AAV 
      patients.
CI  - (c) 2017 British Society for Immunology.
FAU - Cheng, L
AU  - Cheng L
AUID- ORCID: 0000-0001-6624-5906
AD  - Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan 
      University, Chengdu, China.
FAU - Gou, S-J
AU  - Gou SJ
AD  - Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan 
      University, Chengdu, China.
FAU - Qiu, H-Y
AU  - Qiu HY
AD  - Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan 
      University, Chengdu, China.
FAU - Ma, L
AU  - Ma L
AD  - Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan 
      University, Chengdu, China.
FAU - Fu, P
AU  - Fu P
AD  - Division of Nephrology, Kidney Research Institute, West China Hospital of Sichuan 
      University, Chengdu, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171020
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (CD55 Antigens)
RN  - 0 (CD59 Antigens)
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Cofactor Protein)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Adult
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/*immunology/*metabolism/pathology
MH  - Autoantibodies/immunology
MH  - Biomarkers
MH  - Biopsy
MH  - CD55 Antigens/metabolism
MH  - CD59 Antigens/metabolism
MH  - Carrier Proteins/genetics/*metabolism
MH  - Complement Activation/immunology
MH  - Complement System Proteins/*immunology/*metabolism
MH  - Female
MH  - Gene Expression
MH  - Humans
MH  - Immunohistochemistry
MH  - Kidney/*immunology/*metabolism/pathology
MH  - Male
MH  - Membrane Cofactor Protein/metabolism
MH  - Middle Aged
MH  - Protein Binding
MH  - Protein Transport
PMC - PMC5721235
OTO - NOTNLM
OT  - anti-neutrophil cytoplasmic antibody
OT  - complement regulate proteins
OT  - pathology
EDAT- 2017/09/25 06:00
MHDA- 2017/12/23 06:00
PMCR- 2019/01/01
CRDT- 2017/09/24 06:00
PHST- 2017/09/19 00:00 [accepted]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
PHST- 2017/09/24 06:00 [entrez]
PHST- 2019/01/01 00:00 [pmc-release]
AID - CEI13051 [pii]
AID - 10.1111/cei.13051 [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2018 Jan;191(1):116-124. doi: 10.1111/cei.13051. Epub 2017 Oct 
      20.