PMID- 28940887
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20180606
IS  - 1521-2254 (Electronic)
IS  - 1099-498X (Linking)
VI  - 19
IP  - 9-10
DP  - 2017 Sep
TI  - Association of human leukocyte antigen polymorphisms with occult hepatitis B 
      virus infection in a Shaanxi Han population.
LID - 10.1002/jgm.2987 [doi]
AB  - BACKGROUND: Occult hepatitis B virus (HBV) infection (OBI) is defined as HBV DNA 
      detection in serum or in the liver by sensitive diagnostic tests in HBV surface 
      antigen (HBsAg) negative patients with or without serologic markers of previous 
      HBV exposure. Because the human leukocyte antigen (HLA) system is an integral 
      component of the immune response, we hypothesized that the highly polymorphic HLA 
      genes were the key determinants of HBV persistence and clearance. The present 
      study aimed to calculate the allelic frequency of HLA loci and investigate the 
      association between HLA alleles and the outcome of OBI in Shaanxi Han population 
      in the northwest of China. METHODS: We conducted a case-control study between 107 
      OBI subjects and 280 healthy control individuals from blood donors of Shaanxi 
      Blood Center. Five HLA loci, including HLA-A,-B,-C,-DRB1 and -DQB1, were selected 
      and further genotyped using a polymerase chain reaction sequence-based typing 
      (SBT) method. RESULTS: Using the chi-squared test, we found that the allele 
      frequencies of HLA-B*44:03 [odds ratios (OR) = 2.146, 95% confidence interval 
      (CI) = 1.070-4.306, p = 0.028]; C*07:01 (OR = 4.693, CI = 1.822-12.086, 
      p = 0.000); DQB1*02:02 (OR = 1.919, CI = 1.188-3.101, p = 0.007); and DRB1*07:01 
      (OR = 2.012, CI = 1.303-3.107, p = 0.001) were markedly higher in the OBI group 
      compared to the healthy control group. The allele frequencies of HLA-DRB1*08:03 
      (OR = 0.395, CI = 0.152-1.027, p = 0.049); DRB1*15:01 (OR = 0.495, 
      CI = 0.261-0.940, p = 0.029); and DQB1*06:02 (OR = 0.500, CI = 0.249-1.005, 
      p = 0.048) were obviously lower in the OBI group compared to the healthy control 
      group. These data indicated that HLA-B*44:03, C*07:01, DQB1*02:02 and DRB1*07:01 
      were related to OBI infection, whereas HLA-DRB1*08:03, DRB1*15:01 and DQB1*06:02 
      alleles were associated with HBV DNA clearance in a Shaanxi Han population. 
      CONCLUSIONS: The results of the present study suggest that host HLA gene is an 
      important influencing factor for OBI pathogenesis.
CI  - Copyright (c) 2017 John Wiley & Sons, Ltd.
FAU - Wang, Tianju
AU  - Wang T
AD  - Department of Immunology and Pathogenic Biology, School of Basic Medical 
      Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 
      People's Republic of China.
AD  - Blood Center of the Shaanxi Province, Xi'an, Shaanxi, People's Republic of China.
FAU - Shen, Chunmei
AU  - Shen C
AD  - Blood Center of the Shaanxi Province, Xi'an, Shaanxi, People's Republic of China.
FAU - Chen, Liping
AU  - Chen L
AD  - Blood Center of the Shaanxi Province, Xi'an, Shaanxi, People's Republic of China.
FAU - Liu, Sheng
AU  - Liu S
AD  - Blood Center of the Shaanxi Province, Xi'an, Shaanxi, People's Republic of China.
FAU - Ji, Yanhong
AU  - Ji Y
AD  - Department of Immunology and Pathogenic Biology, School of Basic Medical 
      Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 
      People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20171018
PL  - England
TA  - J Gene Med
JT  - The journal of gene medicine
JID - 9815764
RN  - 0 (DNA, Viral)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - China/epidemiology/ethnology
MH  - DNA, Viral
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*genetics/immunology
MH  - Hepatitis B/epidemiology/*genetics/immunology/*virology
MH  - *Hepatitis B virus
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Young Adult
OTO - NOTNLM
OT  - HLA
OT  - OBI
OT  - association analysis
OT  - gene polymorphism
OT  - heterozygote
EDAT- 2017/09/25 06:00
MHDA- 2018/06/07 06:00
CRDT- 2017/09/24 06:00
PHST- 2017/01/21 00:00 [received]
PHST- 2017/08/21 00:00 [revised]
PHST- 2017/09/13 00:00 [accepted]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
PHST- 2017/09/24 06:00 [entrez]
AID - 10.1002/jgm.2987 [doi]
PST - ppublish
SO  - J Gene Med. 2017 Sep;19(9-10). doi: 10.1002/jgm.2987. Epub 2017 Oct 18.